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    CD8A CD8a molecule [ Homo sapiens (human) ]

    Gene ID: 925, updated on 4-Feb-2018
    Official Symbol
    CD8Aprovided by HGNC
    Official Full Name
    CD8a moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:1706
    See related
    Ensembl:ENSG00000153563 MIM:186910; Vega:OTTHUMG00000130265
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD8; MAL; p32; Leu2
    Summary
    The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
    Expression
    Biased expression in spleen (RPKM 38.0), lymph node (RPKM 12.5) and 8 other tissues See more
    Orthologs
    Location:
    2p11.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 2 NC_000002.12 (86784605..86808396, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (87011728..87035519, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNF103-CHMP3 readthrough Neighboring gene uncharacterized LOC105374845 Neighboring gene ring finger protein 103 Neighboring gene required for meiotic nuclear division 5 homolog A Neighboring gene uncharacterized LOC105374846 Neighboring gene CD8b molecule Neighboring gene anaphase promoting complex subunit 1 pseudogene 1 Neighboring gene WW domain binding protein 1 pseudogene Neighboring gene RANBP2-like and GRIP domain containing 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-infected cells are responsible for higher IL-10 secretion after activation, which serves as one of the reasons for suppressed CD8 responses to HIV-1 Pol and Env PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 cytoplasmic tail length determines interaction with CD8A; the presence of an amphipathic sequence in the HIV-1 Env cytoplasmic tail possibly modulates viral receptor specificity by inducing conformational changes in gp120 PubMed
    Nef nef HIV-1 Nef co-localizes with CD8-CD3 zeta on the HEK293 cell surface PubMed
    nef beta-COP as a cellular cofactor is required for HIV-1 Nef-mediated HLA-A2, CD4, and CD8 downregulation PubMed
    nef HIV-inoculated and HIV-1 Nef-treated human peripheral blood lymphocytes downregulate cell surface CD8, and this down-modulation could inhibit anti-HIV cytotoxicity associated with cytotoxic T-cell function PubMed
    Pol gag-pol HIV-infected cells are responsible for higher IL-10 secretion after activation, which serves as one of the reasons for suppressed CD8 responses to HIV-1 Pol and Env PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    MHC class I protein binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    coreceptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    T cell activation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    T cell mediated immunity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    antigen processing and presentation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytotoxic T cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of immune response TAS
    Traceable Author Statement
    more info
     
    transmembrane receptor protein tyrosine kinase signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    T cell receptor complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    plasma membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    T-cell surface glycoprotein CD8 alpha chain
    Names
    CD8 antigen, alpha polypeptide (p32)
    Leu2 T-lymphocyte antigen
    OKT8 T-cell antigen
    T cell co-receptor
    T-cell antigen Leu2
    T-lymphocyte differentiation antigen T8/Leu-2
    T8 T-cell antigen

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011608.2 RefSeqGene

      Range
      5001..28792
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_44

    mRNA and Protein(s)

    1. NM_001145873.1NP_001139345.1  T-cell surface glycoprotein CD8 alpha chain isoform 1 precursor

      See identical proteins and their annotated locations for NP_001139345.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents use of an alternate promoter and 5' UTR, compared to variant 1. Both variants 1 and 3 encode the longer, membrane associated isoform (1).
      Source sequence(s)
      AA668685, AK124156, BC025715, DA075688
      Consensus CDS
      CCDS1992.1
      UniProtKB/Swiss-Prot
      P01732
      UniProtKB/TrEMBL
      Q6ZVS2, Q8TAW8
      Related
      ENSP00000386559.2, OTTHUMP00000203721, ENST00000409511.6, OTTHUMT00000330784
      Conserved Domains (2) summary
      cd05720
      Location:31133
      Ig_CD8_alpha; Immunoglobulin (Ig) like domain of CD8 alpha chain
      smart00410
      Location:28128
      IG_like; Immunoglobulin like
    2. NM_001768.6NP_001759.3  T-cell surface glycoprotein CD8 alpha chain isoform 1 precursor

      See identical proteins and their annotated locations for NP_001759.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer, membrane associated isoform (1). Both variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AC064848, AK124156, BC025715, DB129686
      Consensus CDS
      CCDS1992.1
      UniProtKB/Swiss-Prot
      P01732
      UniProtKB/TrEMBL
      Q6ZVS2, Q8TAW8
      Related
      ENSP00000283635.3, OTTHUMP00000160764, ENST00000283635.7, OTTHUMT00000252596
      Conserved Domains (2) summary
      cd05720
      Location:31133
      Ig_CD8_alpha; Immunoglobulin (Ig) like domain of CD8 alpha chain
      smart00410
      Location:28128
      IG_like; Immunoglobulin like
    3. NM_171827.3NP_741969.1  T-cell surface glycoprotein CD8 alpha chain isoform 2 precursor

      See identical proteins and their annotated locations for NP_741969.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 2) lacks an internal segment including the transmembrane domain compared to isoform 1, resulting in a secreted protein.
      Source sequence(s)
      AC064848, BC025715, DB129686
      Consensus CDS
      CCDS1993.1
      UniProtKB/Swiss-Prot
      P01732
      UniProtKB/TrEMBL
      Q8TAW8
      Related
      ENSP00000321631.3, OTTHUMP00000160760, ENST00000352580.7, OTTHUMT00000252592
      Conserved Domains (2) summary
      cd05720
      Location:31133
      Ig_CD8_alpha; Immunoglobulin (Ig) like domain of CD8 alpha chain
      smart00410
      Location:28128
      IG_like; Immunoglobulin like

    RNA

    1. NR_027353.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate 5' splice pattern, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC064848, AK300089, BC025715, DB129686

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p7 Primary Assembly

      Range
      86784605..86808396 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      86941749..86965554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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