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    Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 [ Mus musculus (house mouse) ]

    Gene ID: 15484, updated on 29-Aug-2017
    Official Symbol
    Hsd11b2provided by MGI
    Official Full Name
    hydroxysteroid 11-beta dehydrogenase 2provided by MGI
    Primary source
    MGI:MGI:104720
    See related
    Ensembl:ENSMUSG00000031891 Vega:OTTMUSG00000062049
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    11HSD2
    Orthologs
    Location:
    8 D3; 8 53.04 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (105518746..105523988)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (108042646..108047888)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene zinc finger, DHHC domain containing 1 Neighboring gene ferritin light chain 1 pseudogene Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit D1 Neighboring gene predicted gene, 38250 Neighboring gene agouti related neuropeptide

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity ISO
    Inferred from Sequence Orthology
    more info
     
    NAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    steroid binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    female pregnancy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucocorticoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of blood volume by renal aldosterone ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    corticosteroid 11-beta-dehydrogenase isozyme 2
    Names
    11-DH2
    11-beta-HSD2
    11-beta-hydroxysteroid dehydrogenase type 2
    NAD-dependent 11-beta-hydroxysteroid dehydrogenase
    NP_032315.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008289.2NP_032315.2  corticosteroid 11-beta-dehydrogenase isozyme 2

      See identical proteins and their annotated locations for NP_032315.2

      Status: VALIDATED

      Source sequence(s)
      AC151573, BB618868, BC066209
      Consensus CDS
      CCDS40460.1
      UniProtKB/Swiss-Prot
      P51661
      UniProtKB/TrEMBL
      Q6NZB9
      Related
      ENSMUSP00000034363.5, OTTMUSP00000078556, ENSMUST00000034363.6, OTTMUST00000151485
      Conserved Domains (2) summary
      cd09805
      Location:83363
      type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs
      pfam00106
      Location:83278
      adh_short; short chain dehydrogenase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      105518746..105523988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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