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    SNF1 AMP-activated serine/threonine-protein kinase catalytic subunit SNF1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852088, updated on 6-Jan-2018
    Gene symbol
    SNF1
    Gene description
    AMP-activated serine/threonine-protein kinase catalytic subunit SNF1
    Primary source
    SGD:S000002885
    Locus tag
    YDR477W
    Gene type
    protein coding
    RNA name
    AMP-activated serine/threonine-protein kinase catalytic subunit SNF1
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CAT1; CCR1; GLC2; HAF3; PAS14
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1412373..1414274)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Jip4p Neighboring gene hypothetical protein Neighboring gene Snm1p Neighboring gene Pex29p

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    AMP-activated protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ARF guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to nitrogen starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fungal-type cell wall assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    invasive growth in response to glucose limitation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of translation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of filamentous growth of a population of unicellular organisms in response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pseudohyphal growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    replicative cell aging IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    replicative cell aging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to unfolded protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    single-species surface biofilm formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    fungal-type vacuole IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear envelope lumen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide-activated protein kinase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleotide-activated protein kinase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Names
    AMP-activated serine/threonine-protein kinase catalytic subunit SNF1
    NP_010765.3
    • AMP-activated S/T protein kinase; forms a complex with Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; regulates nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth and acts as a non-canonical GEF, activating Arf3p during invasive growth; SUMOylation by Mms21p inhibits its function and targets Snf1p for destruction via the Slx5-Slx8 Ub ligase

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1412373..1414274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180785.3NP_010765.3  TPA: AMP-activated serine/threonine-protein kinase catalytic subunit SNF1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010765.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P06782
      Conserved Domains (3) summary
      cd14079
      Location:52306
      STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase
      pfam08587
      Location:344389
      UBA_2; Ubiquitin associated domain (UBA)
      pfam16579
      Location:504626
      AdenylateSensor; Adenylate sensor of SNF1-like protein kinase
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