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    GOLPH3 golgi phosphoprotein 3 [ Homo sapiens (human) ]

    Gene ID: 64083, updated on 23-Apr-2017
    Official Symbol
    GOLPH3provided by HGNC
    Official Full Name
    golgi phosphoprotein 3provided by HGNC
    Primary source
    HGNC:HGNC:15452
    See related
    Ensembl:ENSG00000113384 MIM:612207; Vega:OTTHUMG00000090679
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GOPP1; GPP34; MIDAS; Vps74
    Summary
    The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a peripheral membrane protein of the Golgi stack and may have a regulatory role in Golgi trafficking. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    5p13.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 5 NC_000005.10 (32124711..32174319, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (32124817..32174425, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene PDZ domain containing 2 Neighboring gene microRNA 4279 Neighboring gene uncharacterized LOC105374711 Neighboring gene RNA, U6 small nuclear 1079, pseudogene Neighboring gene ribosomal protein L27 pseudogene 10 Neighboring gene myotubularin related protein 12

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    Knockdown of golgi phosphoprotein 3 (GOLPH3) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr is identified to have a physical interaction with golgi phosphoprotein 3 (GOLPH3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ90675

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    phosphatidylinositol-4-phosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Golgi ribbon formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Golgi to plasma membrane protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Golgi vesicle budding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    asymmetric Golgi ribbon formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell adhesion molecule production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glycoprotein biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    leukocyte tethering or rolling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein retention in Golgi apparatus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitochondrion organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    retrograde vesicle-mediated transport, Golgi to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    Golgi apparatus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Golgi cisterna IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    Golgi phosphoprotein 3
    Names
    coat protein GPP34
    coat-protein
    golgi peripheral membrane protein 1, 34 kDa
    golgi protein
    golgi-associated protein
    mitochondrial DNA absence factor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022130.3NP_071413.1  Golgi phosphoprotein 3

      See identical proteins and their annotated locations for NP_071413.1

      Status: REVIEWED

      Source sequence(s)
      AK075156
      Consensus CDS
      CCDS3896.1
      UniProtKB/Swiss-Prot
      Q9H4A6
      Related
      ENSP00000265070.6, OTTHUMP00000115847, ENST00000265070.6, OTTHUMT00000207363
      Conserved Domains (1) summary
      pfam05719
      Location:62271
      GPP34; Golgi phosphoprotein 3 (GPP34)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p7 Primary Assembly

      Range
      32124711..32174319 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017009686.1XP_016865175.1  Golgi phosphoprotein 3 isoform X1

      Conserved Domains (1) summary
      pfam05719
      Location:2179
      GPP34; Golgi phosphoprotein 3 (GPP34)
    2. XM_017009687.1XP_016865176.1  Golgi phosphoprotein 3 isoform X1

      Conserved Domains (1) summary
      pfam05719
      Location:2179
      GPP34; Golgi phosphoprotein 3 (GPP34)

    Alternate CHM1_1.1

    Genomic

    1. NC_018916.2 Alternate CHM1_1.1

      Range
      32126145..32175750 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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