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    Slc12a5 solute carrier family 12, member 5 [ Mus musculus (house mouse) ]

    Gene ID: 57138, updated on 22-Apr-2017
    Official Symbol
    Slc12a5provided by MGI
    Official Full Name
    solute carrier family 12, member 5provided by MGI
    Primary source
    MGI:MGI:1862037
    See related
    Ensembl:ENSMUSG00000017740 Vega:OTTMUSG00000019699
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KCC2; mKIAA1176
    Orthologs
    Location:
    2; 2 H3
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (164960821..164999731)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (164793488..164825231)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 335 Neighboring gene zinc finger protein 335, opposite strand Neighboring gene matrix metallopeptidase 9 Neighboring gene predicted gene, 46776 Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene Neighboring gene nuclear receptor coactivator 5 Neighboring gene CD40 antigen

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ammonium transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    cation:chloride symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    chloride transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    potassium ion symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    potassium:chloride symporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    potassium:chloride symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    ammonium transport ISO
    Inferred from Sequence Orthology
    more info
     
    cellular chloride ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    chloride transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chloride transport ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular pH reduction ISO
    Inferred from Sequence Orthology
    more info
     
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    response to drug IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    thermosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite membrane ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic shaft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    solute carrier family 12 member 5
    Names
    K-Cl cotransporter 2
    KCC2a variant 1
    KCC2a-S25 variant 1
    KCC2b variant 2
    electroneutral potassium-chloride cotransporter 2
    mKCC2
    neuronal K-Cl cotransporter

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020333.2NP_065066.2  solute carrier family 12 member 5

      See identical proteins and their annotated locations for NP_065066.2

      Status: VALIDATED

      Source sequence(s)
      AK147262, BC054808
      Consensus CDS
      CCDS38332.1
      UniProtKB/Swiss-Prot
      Q91V14
      UniProtKB/TrEMBL
      A0A076FSX1
      Related
      ENSMUSP00000096690.4, OTTMUSP00000001056, ENSMUST00000099092.7, OTTMUST00000002164
      Conserved Domains (2) summary
      TIGR00930
      Location:211115
      2a30; K-Cl cotransporter
      pfam03522
      Location:6891115
      SLC12; Solute carrier family 12

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      164960821..164999731
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499943.3XP_006500006.2  solute carrier family 12 member 5 isoform X1

      See identical proteins and their annotated locations for XP_006500006.2

      UniProtKB/Swiss-Prot
      Q91V14
      UniProtKB/TrEMBL
      A0A076FRG6
      Related
      ENSMUSP00000144623.1, OTTMUSP00000072499, ENSMUST00000202623.3, OTTMUST00000137740
      Conserved Domains (2) summary
      TIGR00930
      Location:441138
      2a30; K-Cl cotransporter
      pfam03522
      Location:7121138
      SLC12; Solute carrier family 12
    2. XM_006499944.3XP_006500007.2  solute carrier family 12 member 5 isoform X2

      See identical proteins and their annotated locations for XP_006500007.2

      UniProtKB/TrEMBL
      A0A076FR46
      Related
      ENSMUSP00000143870.1, OTTMUSP00000072509, ENSMUST00000202223.3, OTTMUST00000137767
      Conserved Domains (2) summary
      TIGR00930
      Location:441133
      2a30; K-Cl cotransporter
      pfam03522
      Location:7121133
      SLC12; Solute carrier family 12
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