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    CSE4 centromeric DNA-binding histone H3-like protein CSE4 [ Saccharomyces cerevisiae S288c ]

    Gene ID: 853817, updated on 15-Nov-2016
    Gene symbol
    CSE4
    Gene description
    centromeric DNA-binding histone H3-like protein CSE4
    Primary source
    SGD:S000001532
    Locus tag
    YKL049C
    Gene type
    protein coding
    RNA name
    centromeric DNA-binding histone H3-like protein CSE4
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CSL2
    See CSE4 in Map Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (346075..346764, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Sfk1p Neighboring gene hypothetical protein Neighboring gene serine/threonine protein kinase ELM1 Neighboring gene Anr2p

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    centromeric DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleosomal DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    2-micrometer plasmid partitioning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    kinetochore assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    CENP-A containing nucleosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    condensed chromosome kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    condensed nuclear chromosome, centromeric region IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    extrachromosomal circular DNA IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    kinetochore IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    nucleosome IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    centromeric DNA-binding histone H3-like protein CSE4
    NP_012875.2
    • Histone H3-like centromere protein; associated with promoters, accessible chromatin, RNAPII-bound regions; phosphorylated Cse4p associates with centromeres; required for proper kinetochore function; levels regulated by E3 ubiquitin ligase Psh1p; phosphorylation may destabilize defective kinetochores to promote bi-orientation; ubiquitination of N-terminus regulates proteolysis for faithful chromosome segregation; yeast CSE4 can complement mutations in human homolog CENPA

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      346075..346764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179615.1NP_012875.2  TPA: centromeric DNA-binding histone H3-like protein CSE4 [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_012875.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P36012
      Conserved Domains (2) summary
      smart00428
      Location:124229
      H3; Histone H3
      pfam00125
      Location:98225
      Histone; Core histone H2A/H2B/H3/H4
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