Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Meis1 Meis homeobox 1 [ Mus musculus (house mouse) ]

    Gene ID: 17268, updated on 19-May-2018
    Official Symbol
    Meis1provided by MGI
    Official Full Name
    Meis homeobox 1provided by MGI
    Primary source
    MGI:MGI:104717
    See related
    Ensembl:ENSMUSG00000020160 Vega:OTTMUSG00000005212
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Evi8; C530044H18Rik
    Expression
    Broad expression in bladder adult (RPKM 25.6), CNS E11.5 (RPKM 9.3) and 19 other tissues See more
    Orthologs
    See Meis1 in Genome Data Viewer
    Location:
    11 A3.1; 11 11.11 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (18880428..19020672, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (18780431..18918683, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 31674 Neighboring gene predicted gene 28401 Neighboring gene RIKEN cDNA 8430419K02 gene Neighboring gene uncharacterized LOC101055656 Neighboring gene RIKEN cDNA 4933406G16 gene Neighboring gene predicted gene 12026

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    definitive hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lens morphogenesis in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    megakaryocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cardiac muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of myeloid cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription by RNA polymerase II IC
    Inferred by Curator
    more info
    PubMed 
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    homeobox protein Meis1
    Names
    myeloid ecotropic viral integration site 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193271.1NP_001180200.1  homeobox protein Meis1 isoform B

      See identical proteins and their annotated locations for NP_001180200.1

      Status: VALIDATED

      Description
      Transcript Variant: : This variant (B) includes an alternate exon in the 3' coding region, which results in a frameshift, compared to variant A. The resulting protein (isoform B) has a shorter and distinct C-terminus, compared to isoform A.
      Source sequence(s)
      AK140748, AL645570
      Consensus CDS
      CCDS56760.1
      UniProtKB/Swiss-Prot
      Q60954
      Related
      ENSMUSP00000069277.7, OTTMUSP00000005401, ENSMUST00000068264.13, OTTMUST00000011633
      Conserved Domains (2) summary
      pfam05920
      Location:290329
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:108191
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    2. NM_010789.3NP_034919.1  homeobox protein Meis1 isoform A

      See identical proteins and their annotated locations for NP_034919.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A) encodes the longer isoform (A).
      Source sequence(s)
      AL603984, AL645570
      Consensus CDS
      CCDS24453.1
      UniProtKB/Swiss-Prot
      Q60954
      Related
      ENSMUSP00000139219.1, ENSMUST00000185131.7
      Conserved Domains (2) summary
      pfam05920
      Location:290329
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:108191
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      18880428..19020672 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514559.3XP_006514622.1  homeobox protein Meis1 isoform X1

      Conserved Domains (2) summary
      pfam05920
      Location:241280
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:108161
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    2. XM_017314312.1XP_017169801.1  homeobox protein Meis1 isoform X2

    3. XM_017314313.1XP_017169802.1  homeobox protein Meis1 isoform X3

    RNA

    1. XR_001779899.1 RNA Sequence

    2. XR_001779900.1 RNA Sequence

    Support Center