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    NTRK2 neurotrophic receptor tyrosine kinase 2 [ Homo sapiens (human) ]

    Gene ID: 4915, updated on 16-Apr-2018
    Official Symbol
    NTRK2provided by HGNC
    Official Full Name
    neurotrophic receptor tyrosine kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:8032
    See related
    Ensembl:ENSG00000148053 MIM:600456; Vega:OTTHUMG00000020120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OBHD; TRKB; trk-B; EIEE58; GP145-TrkB
    Summary
    This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
    Expression
    Biased expression in brain (RPKM 64.6), thyroid (RPKM 30.4) and 3 other tissues See more
    Orthologs
    Location:
    9q21.33
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (84668458..85027070)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (87283417..87641985)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 28 member 3 Neighboring gene SLC28A3 intron nontranscribed chromatin-defined enhancer Neighboring gene uncharacterized LOC102724036 Neighboring gene uncharacterized LOC105376118 Neighboring gene uncharacterized LOC107987088

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 58
    MedGen: CN757795 OMIM: 617830 GeneReviews: Not available
    not available
    Obesity, hyperphagia, and developmental delay
    MedGen: C3151303 OMIM: 613886 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
    NHGRI GWA Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    NHGRI GWA Catalog
    Variants close to NTRK2 gene are associated with birth weight in female twins.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 Env (gp120) exposure downregulates TrkA, TrkB, and TrkC mRNA levels in dorsal root ganglion neurons PubMed

    Go to the HIV-1, Human Interaction Database

    • Activation of TRKA receptors, organism-specific biosystem (from REACTOME)
      Activation of TRKA receptors, organism-specific biosystemTrk receptors can either be activated by neurotrophins or by two G-protein-coupled receptors (GPCRs) although the biological relevance of GPCRs remains to be shown.
    • Alcoholism, organism-specific biosystem (from KEGG)
      Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Alcoholism, conserved biosystem (from KEGG)
      Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • BDNF-TrkB Signaling, organism-specific biosystem (from WikiPathways)
      BDNF-TrkB Signaling, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is an important neurotrophin for the regulation of synaptic activity. BDNF-TrkB signaling, TrkB being the receptor of BDNF, is involved in transcription, tran...
    • Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystem (from WikiPathways)
      Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
    • ERK Pathway in Huntington's Disease, organism-specific biosystem (from WikiPathways)
      ERK Pathway in Huntington's Disease, organism-specific biosystemThis ERK pathway is implicated in Huntington's Disease. The ligands BDNF, EGF, and Glu bind to their respective receptors (TrkB, EGFR, mGluR) and start a signal transduction pathway starting with RAS...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
      NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
    • NGF-independant TRKA activation, organism-specific biosystem (from REACTOME)
      NGF-independant TRKA activation, organism-specific biosystemTRK receptors can also be activated by at least two G-protein-coupled receptors (GPCR), the adenosine A2a receptor and the PACAP type I receptor, without involvement of neurotrophins. Activity of bo...
    • Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem
      Neurotrophic factor-mediated Trk receptor signaling
    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
      Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
      Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
      Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    MAP kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    brain-derived neurotrophic factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    brain-derived neurotrophic factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    brain-derived neurotrophic factor-activated receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    brain-derived neurotrophic factor-activated receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitogen-activated protein kinase kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    neurotrophin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    neurotrophin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neurotrophin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neurotrophin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    signal transducer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    brain-derived neurotrophic factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    brain-derived neurotrophic factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cellular response to amino acid stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to nerve growth factor stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    central nervous system neuron development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cerebral cortex development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    circadian rhythm IEA
    Inferred from Electronic Annotation
    more info
     
    feeding behavior IEA
    Inferred from Electronic Annotation
    more info
     
    glutamate secretion IEA
    Inferred from Electronic Annotation
    more info
     
    learning ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
     
    mechanoreceptor differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of anoikis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    neuromuscular junction development IEA
    Inferred from Electronic Annotation
    more info
     
    neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neurotrophin signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    oligodendrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    peripheral nervous system neuron development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of axonogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of synapse assembly IEA
    Inferred from Electronic Annotation
    more info
     
    protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of protein kinase B signaling IEA
    Inferred from Electronic Annotation
    more info
     
    retina development in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
     
    retinal rod cell development IEA
    Inferred from Electronic Annotation
    more info
     
    trans-synaptic signaling by neuropeptide, modulating synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    trans-synaptic signaling by neuropeptide, modulating synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    vasculogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    axon terminus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    terminal bouton IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    BDNF/NT-3 growth factors receptor
    Names
    BDNF-tropomyosine receptor kinase B
    neurotrophic tyrosine kinase receptor type 2
    tropomyosin-related kinase B
    tyrosine kinase receptor B
    NP_001007098.1
    NP_001018074.1
    NP_001018075.1
    NP_001018076.1
    NP_001278866.1
    NP_006171.2
    XP_005252058.1
    XP_005252060.1
    XP_005252061.1
    XP_005252063.1
    XP_005252064.1
    XP_011517020.1
    XP_011517022.1
    XP_016870240.1
    XP_016870241.1
    XP_016870242.1
    XP_016870243.1
    XP_016870244.1
    XP_016870245.1
    XP_016870246.1
    XP_016870247.1
    XP_016870248.1
    XP_016870249.1
    XP_016870250.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012201.2 RefSeqGene

      Range
      4908..363520
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001007097.2NP_001007098.1  BDNF/NT-3 growth factors receptor isoform b precursor

      See identical proteins and their annotated locations for NP_001007098.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (b, also known as TrkB-T1) lacks several 3' exons but contains an alternate 3' terminal exon (exon 16 in PMID:11798182), and it thus differs in the 3' coding region and 3' UTR, compared to variant a. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a. The 5' UTR is incomplete due to a lack of 5'-complete transcript support for this variant, and because there is ambiguity in the 5' UTR splicing pattern.
      Source sequence(s)
      AB209118, AL713745, AL833196, BC031835, BE148667, HY311899
      Consensus CDS
      CCDS35053.1
      UniProtKB/Swiss-Prot
      Q16620
      UniProtKB/TrEMBL
      Q5VWE5
      Related
      ENSP00000379221.1, ENST00000395882.5
      Conserved Domains (6) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      sd00031
      Location:96116
      LRR_1; leucine-rich repeat [structural motif]
      pfam01462
      Location:3160
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      cl15307
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl28434
      Location:205283
      I-set; Immunoglobulin I-set domain
    2. NM_001018064.2NP_001018074.1  BDNF/NT-3 growth factors receptor isoform c precursor

      See identical proteins and their annotated locations for NP_001018074.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (c) lacks an alternate in-frame exon in the central coding region, compared to variant a, resulting in an isoform (c) that is shorter than isoform a. The 5' UTR is incomplete due to a lack of 5'-complete transcript support for this variant, and because there is ambiguity in the 5' UTR splicing pattern.
      Source sequence(s)
      AK289904, AL445532, BX649001, U12140
      Consensus CDS
      CCDS35050.1
      UniProtKB/Swiss-Prot
      Q16620
      UniProtKB/TrEMBL
      Q548C2, Q5VWE5
      Related
      ENSP00000314586.4, OTTHUMP00000021573, ENST00000323115.8, OTTHUMT00000052882
      Conserved Domains (5) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      cd05093
      Location:532819
      PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl28434
      Location:205283
      I-set; Immunoglobulin I-set domain
    3. NM_001018065.2NP_001018075.1  BDNF/NT-3 growth factors receptor isoform d precursor

      See identical proteins and their annotated locations for NP_001018075.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (d) lacks several 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant a. The encoded isoform (d, also known as TrkB-T-Shc) has a distinct C-terminus and is shorter than isoform a. The 5' UTR is incomplete due to a lack of 5'-complete transcript support for this variant, and because there is ambiguity in the 5' UTR splicing pattern.
      Source sequence(s)
      AB209118, AF410901, AL596132
      Consensus CDS
      CCDS35051.1
      UniProtKB/Swiss-Prot
      Q16620
      Related
      ENSP00000306167.6, OTTHUMP00000021575, ENST00000304053.10, OTTHUMT00000052884
      Conserved Domains (6) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      sd00031
      Location:96116
      LRR_1; leucine-rich repeat [structural motif]
      pfam01462
      Location:3160
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl28434
      Location:205283
      I-set; Immunoglobulin I-set domain
    4. NM_001018066.2NP_001018076.1  BDNF/NT-3 growth factors receptor isoform e precursor

      See identical proteins and their annotated locations for NP_001018076.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (e) lacks an alternate in-frame exon in the central coding region, and also lacks several 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant a. The encoded isoform (e, also known as TrkB-T-Shc) has a distinct C-terminus and is shorter than isoform a. The 5' UTR is incomplete due to a lack of 5'-complete transcript support for this variant, and because there is ambiguity in the 5' UTR splicing pattern.
      Source sequence(s)
      AB209118, AF410901, AL596132
      Consensus CDS
      CCDS35052.1
      UniProtKB/Swiss-Prot
      Q16620
      Related
      ENSP00000365381.1, OTTHUMP00000021574, ENST00000376208.5, OTTHUMT00000052883
      Conserved Domains (6) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      sd00031
      Location:96116
      LRR_1; leucine-rich repeat [structural motif]
      pfam01462
      Location:3160
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl28434
      Location:205283
      I-set; Immunoglobulin I-set domain
    5. NM_001291937.1NP_001278866.1  BDNF/NT-3 growth factors receptor isoform f precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (f) uses an alternate in-frame splice site in the central coding region, and lacks several 3' exons but contains an alternate 3' terminal exon and it thus differs in the 3' coding region and 3' UTR, compared to variant a. The encoded isoform (f) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AL390777, AL713745, AL833196, BC075804, BE148667, DA449367, HY311899
      Conserved Domains (7) summary
      cd05855
      Location:288366
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      smart00408
      Location:210273
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:204283
      IG_like; Immunoglobulin like
      sd00031
      Location:96116
      LRR_1; leucine-rich repeat [structural motif]
      pfam01462
      Location:3160
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      cl15307
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    6. NM_006180.4NP_006171.2  BDNF/NT-3 growth factors receptor isoform a precursor

      See identical proteins and their annotated locations for NP_006171.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (a, also known as TrkB) represents the longest transcript and encodes the longest isoform (a). The 5' UTR exon structure is inferred due to a lack of 5'-complete transcript support for this variant.
      Source sequence(s)
      AF410899, AK289904, AL390777, AL445532, BX649001, DA283111, DA449367
      Consensus CDS
      CCDS6671.1
      UniProtKB/Swiss-Prot
      Q16620
      UniProtKB/TrEMBL
      A0A024R230, Q5VWE5
      Related
      ENSP00000365387.1, ENST00000376214.5
      Conserved Domains (5) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      cd05093
      Location:548835
      PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl28434
      Location:205283
      I-set; Immunoglobulin I-set domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

      Range
      84668458..85027070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017014751.2XP_016870240.1  BDNF/NT-3 growth factors receptor isoform X1

      UniProtKB/Swiss-Prot
      Q16620
      UniProtKB/TrEMBL
      A0A024R230
      Conserved Domains (5) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      cd05093
      Location:548835
      PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl28434
      Location:205283
      I-set; Immunoglobulin I-set domain
    2. XM_017014753.2XP_016870242.1  BDNF/NT-3 growth factors receptor isoform X2

      UniProtKB/Swiss-Prot
      Q16620
      UniProtKB/TrEMBL
      Q548C2
      Conserved Domains (5) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      cd05093
      Location:532819
      PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl28434
      Location:205283
      I-set; Immunoglobulin I-set domain
    3. XM_017014760.2XP_016870249.1  BDNF/NT-3 growth factors receptor isoform X5

      UniProtKB/Swiss-Prot
      Q16620
      UniProtKB/TrEMBL
      Q5VWE5
      Conserved Domains (6) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      sd00031
      Location:96116
      LRR_1; leucine-rich repeat [structural motif]
      pfam01462
      Location:3160
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      cl15307
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl28434
      Location:205283
      I-set; Immunoglobulin I-set domain
    4. XM_005252001.3XP_005252058.1  BDNF/NT-3 growth factors receptor isoform X1

      See identical proteins and their annotated locations for XP_005252058.1

      UniProtKB/Swiss-Prot
      Q16620
      UniProtKB/TrEMBL
      A0A024R230
      Conserved Domains (5) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      cd05093
      Location:548835
      PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl28434
      Location:205283
      I-set; Immunoglobulin I-set domain
    5. XM_011518720.3XP_011517022.1  BDNF/NT-3 growth factors receptor isoform X4

      See identical proteins and their annotated locations for XP_011517022.1

      UniProtKB/Swiss-Prot
      Q16620
      Conserved Domains (6) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      sd00031
      Location:96116
      LRR_1; leucine-rich repeat [structural motif]
      pfam01462
      Location:3160
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl28434
      Location:205283
      I-set; Immunoglobulin I-set domain
    6. XM_005252007.4XP_005252064.1  BDNF/NT-3 growth factors receptor isoform X5

      See identical proteins and their annotated locations for XP_005252064.1

      UniProtKB/Swiss-Prot
      Q16620
      UniProtKB/TrEMBL
      Q5VWE5
      Conserved Domains (6) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      sd00031
      Location:96116
      LRR_1; leucine-rich repeat [structural motif]
      pfam01462
      Location:3160
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      cl15307
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl28434
      Location:205283
      I-set; Immunoglobulin I-set domain
    7. XM_017014756.1XP_016870245.1  BDNF/NT-3 growth factors receptor isoform X3

      UniProtKB/Swiss-Prot
      Q16620
      Conserved Domains (6) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      sd00031
      Location:96116
      LRR_1; leucine-rich repeat [structural motif]
      pfam01462
      Location:3160
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl28434
      Location:205283
      I-set; Immunoglobulin I-set domain
    8. XM_017014759.1XP_016870248.1  BDNF/NT-3 growth factors receptor isoform X5

      UniProtKB/Swiss-Prot
      Q16620
      UniProtKB/TrEMBL
      Q5VWE5
      Conserved Domains (6) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      sd00031
      Location:96116
      LRR_1; leucine-rich repeat [structural motif]
      pfam01462
      Location:3160
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      cl15307
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl28434
      Location:205283
      I-set; Immunoglobulin I-set domain
    9. XM_011518718.3XP_011517020.1  BDNF/NT-3 growth factors receptor isoform X2

      See identical proteins and their annotated locations for XP_011517020.1

      UniProtKB/Swiss-Prot
      Q16620
      UniProtKB/TrEMBL
      Q548C2
      Conserved Domains (5) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      cd05093
      Location:532819
      PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl28434
      Location:205283
      I-set; Immunoglobulin I-set domain
    10. XM_017014752.1XP_016870241.1  BDNF/NT-3 growth factors receptor isoform X2

      UniProtKB/Swiss-Prot
      Q16620
      UniProtKB/TrEMBL
      Q548C2
      Related
      ENSP00000365386.1, ENST00000376213.5
      Conserved Domains (5) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      cd05093
      Location:532819
      PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl28434
      Location:205283
      I-set; Immunoglobulin I-set domain
    11. XM_017014755.1XP_016870244.1  BDNF/NT-3 growth factors receptor isoform X3

      UniProtKB/Swiss-Prot
      Q16620
      Conserved Domains (6) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      sd00031
      Location:96116
      LRR_1; leucine-rich repeat [structural motif]
      pfam01462
      Location:3160
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl28434
      Location:205283
      I-set; Immunoglobulin I-set domain
    12. XM_017014757.1XP_016870246.1  BDNF/NT-3 growth factors receptor isoform X4

      UniProtKB/Swiss-Prot
      Q16620
      Conserved Domains (6) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      sd00031
      Location:96116
      LRR_1; leucine-rich repeat [structural motif]
      pfam01462
      Location:3160
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl28434
      Location:205283
      I-set; Immunoglobulin I-set domain
    13. XM_005252006.4XP_005252063.1  BDNF/NT-3 growth factors receptor isoform X3

      See identical proteins and their annotated locations for XP_005252063.1

      UniProtKB/Swiss-Prot
      Q16620
      Conserved Domains (6) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      sd00031
      Location:96116
      LRR_1; leucine-rich repeat [structural motif]
      pfam01462
      Location:3160
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl28434
      Location:205283
      I-set; Immunoglobulin I-set domain
    14. XM_017014758.1XP_016870247.1  BDNF/NT-3 growth factors receptor isoform X5

      UniProtKB/Swiss-Prot
      Q16620
      UniProtKB/TrEMBL
      Q5VWE5
      Conserved Domains (6) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      sd00031
      Location:96116
      LRR_1; leucine-rich repeat [structural motif]
      pfam01462
      Location:3160
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      cl15307
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl28434
      Location:205283
      I-set; Immunoglobulin I-set domain
    15. XM_005252003.3XP_005252060.1  BDNF/NT-3 growth factors receptor isoform X1

      See identical proteins and their annotated locations for XP_005252060.1

      UniProtKB/Swiss-Prot
      Q16620
      UniProtKB/TrEMBL
      A0A024R230
      Conserved Domains (5) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      cd05093
      Location:548835
      PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl28434
      Location:205283
      I-set; Immunoglobulin I-set domain
    16. XM_005252004.2XP_005252061.1  BDNF/NT-3 growth factors receptor isoform X1

      See identical proteins and their annotated locations for XP_005252061.1

      UniProtKB/Swiss-Prot
      Q16620
      UniProtKB/TrEMBL
      A0A024R230
      Related
      ENSP00000277120.3, OTTHUMP00000021576, ENST00000277120.7, OTTHUMT00000052885
      Conserved Domains (5) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      cd05093
      Location:548835
      PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl28434
      Location:205283
      I-set; Immunoglobulin I-set domain
    17. XM_017014754.1XP_016870243.1  BDNF/NT-3 growth factors receptor isoform X2

      UniProtKB/Swiss-Prot
      Q16620
      UniProtKB/TrEMBL
      Q548C2
      Conserved Domains (5) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      cd05093
      Location:532819
      PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl28434
      Location:205283
      I-set; Immunoglobulin I-set domain
    18. XM_017014761.1XP_016870250.1  BDNF/NT-3 growth factors receptor isoform X5

      UniProtKB/Swiss-Prot
      Q16620
      UniProtKB/TrEMBL
      Q5VWE5
      Conserved Domains (6) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      sd00031
      Location:96116
      LRR_1; leucine-rich repeat [structural motif]
      pfam01462
      Location:3160
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      cl15307
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl28434
      Location:205283
      I-set; Immunoglobulin I-set domain
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