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    CNP 2',3'-cyclic nucleotide 3' phosphodiesterase [ Homo sapiens (human) ]

    Gene ID: 1267, updated on 18-Apr-2017
    Official Symbol
    CNPprovided by HGNC
    Official Full Name
    2',3'-cyclic nucleotide 3' phosphodiesteraseprovided by HGNC
    Primary source
    HGNC:HGNC:2158
    See related
    Ensembl:ENSG00000173786 MIM:123830; Vega:OTTHUMG00000133502
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CNP1
    Orthologs
    Location:
    17q21.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (41966741..41977736)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40118737..40129754)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATP citrate lyase Neighboring gene tetratricopeptide repeat domain 25 Neighboring gene DnaJ heat shock protein family (Hsp40) member C7 Neighboring gene NFKB inhibitor interacting Ras like 2 Neighboring gene zinc finger protein 385C Neighboring gene DExH-box helicase 58

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag CNP targets the MA domain of the HIV-1 Gag protein following its association with the plasma membrane. CNP is packaged into the interior of virions and is resistant to digestion by subtilisin PubMed
    gag CNP inhibits cell-associated HIV-1 Gag processing and reduces particulate CA protein in the supernatant of transfected cells PubMed
    gag CNP binds directly to HIV-1 Gag and inhibits an early step in virion assembly in cells. HIV-1 Gag E40K mutant abolishes the inhibition of Gag assembly by CNP PubMed
    Tat tat HIV-1 Tat decreases the intracellular levels of cAMP and CREB ser-133 phosphorylation through a signal transduction pathway involving sequential activation of phosphatidylinositol 3-kinase, AKT, and cyclic nucleoside phosphodiesterases PubMed
    capsid gag CNP inhibits cell-associated HIV-1 Gag processing and reduces particulate CA protein in the supernatant of transfected cells PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    2',3'-cyclic-nucleotide 3'-phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    cyclic nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    adult locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    aging IEA
    Inferred from Electronic Annotation
    more info
     
    axonogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    chemical synaptic transmission TAS
    Traceable Author Statement
    more info
    PubMed 
    cyclic nucleotide catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    forebrain development IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    oligodendrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of mitochondrial membrane permeability IEA
    Inferred from Electronic Annotation
    more info
     
    response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
     
    substantia nigra development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microvillus IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath abaxonal region IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath adaxonal region IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    pseudopodium IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    2',3'-cyclic-nucleotide 3'-phosphodiesterase
    Names
    2', 3' cyclic nucleotide 3' phosphohydrolase
    CNPase
    NP_149124.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330216.1NP_001317145.1  2',3'-cyclic-nucleotide 3'-phosphodiesterase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125257, HY337437
      Consensus CDS
      CCDS82123.1
      UniProtKB/Swiss-Prot
      P09543
      UniProtKB/TrEMBL
      A0A024R1T5
    2. NM_033133.4NP_149124.3  2',3'-cyclic-nucleotide 3'-phosphodiesterase isoform 1

      See identical proteins and their annotated locations for NP_149124.3

      Status: VALIDATED

      Source sequence(s)
      AC125257
      Consensus CDS
      CCDS11414.2
      UniProtKB/Swiss-Prot
      P09543
      Related
      ENSP00000377470.2, OTTHUMP00000164760, ENST00000393892.7, OTTHUMT00000257443
      Conserved Domains (2) summary
      pfam05881
      Location:187399
      CNPase; 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase)
      cl17190
      Location:51166
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

      Range
      41966741..41977736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011524340.2XP_011522642.1  2',3'-cyclic-nucleotide 3'-phosphodiesterase isoform X1

      See identical proteins and their annotated locations for XP_011522642.1

      UniProtKB/Swiss-Prot
      P09543
      UniProtKB/TrEMBL
      A0A024R1T5
      Related
      ENSP00000377466.1, OTTHUMP00000164761, ENST00000393888.1, OTTHUMT00000257444
      Conserved Domains (2) summary
      pfam05881
      Location:167379
      CNPase; 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase)
      cl17190
      Location:31146
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    2. XM_006721701.3XP_006721764.1  2',3'-cyclic-nucleotide 3'-phosphodiesterase isoform X1

      Conserved Domains (2) summary
      pfam05881
      Location:167379
      CNPase; 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase)
      cl17190
      Location:31146
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      40354523..40365518
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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