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    Bcl11b B cell leukemia/lymphoma 11B [ Mus musculus (house mouse) ]

    Gene ID: 58208, updated on 22-Nov-2017
    Official Symbol
    Bcl11bprovided by MGI
    Official Full Name
    B cell leukemia/lymphoma 11Bprovided by MGI
    Primary source
    MGI:MGI:1929913
    See related
    Ensembl:ENSMUSG00000048251 Vega:OTTMUSG00000019485
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rit1; Ctip2; BCL-11B; AI604821; 9130430L19Rik; B630002E05Rik
    Orthologs
    Location:
    12 F1; 12 59.1 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (107910403..108004139, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (109148613..109241624, complement)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930465M20 gene Neighboring gene predicted gene, 33341 Neighboring gene SET domain containing 3 Neighboring gene cyclin K

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA polymerase II proximal promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    T cell differentiation in thymus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    T cell receptor V(D)J recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    alpha-beta T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    central nervous system neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    commitment of neuronal cell to specific neuron type in forebrain IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    epithelial cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hematopoietic stem cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    keratinocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lymphoid lineage cell migration into thymus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    odontogenesis of dentin-containing tooth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    olfactory bulb axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive T cell selection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    post-embryonic camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of keratinocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    skin development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    striatal medium spiny neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    thymus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    intracellular IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron part IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    B-cell lymphoma/leukemia 11B
    Names
    B-cell CLL/lymphoma 11B
    B-cell lymphoma/leukaemia 11B
    COUP-TF-interacting protein 2
    mRit1
    radiation-induced tumor suppressor gene 1 protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079883.1NP_001073352.1  B-cell lymphoma/leukemia 11B isoform a

      See identical proteins and their annotated locations for NP_001073352.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC119219, AC119921, BM950501, BQ442983, CV563304
      Consensus CDS
      CCDS36553.1
      UniProtKB/Swiss-Prot
      Q99PV8
      Related
      ENSMUSP00000068258.4, OTTMUSP00000021002, ENSMUST00000066060.10, OTTMUST00000046516
      Conserved Domains (3) summary
      sd00017
      Location:788808
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:787808
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:800825
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001286343.1NP_001273272.1  B-cell lymphoma/leukemia 11B isoform c

      See identical proteins and their annotated locations for NP_001273272.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two internal coding exons but maintains the reading frame, compared to variant 1. The resulting isoform (c) lacks an internal segment, compared to isoform a.
      Source sequence(s)
      AC119219, AC119921
      Consensus CDS
      CCDS70419.1
      UniProtKB/Swiss-Prot
      Q99PV8
      UniProtKB/TrEMBL
      A0A0R4J1E1
      Related
      ENSMUSP00000105513.1, OTTMUSP00000021003, ENSMUST00000109887.7, OTTMUST00000046517
      Conserved Domains (3) summary
      sd00017
      Location:594614
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:593614
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:606631
      zf-H2C2_2; Zinc-finger double domain
    3. NM_021399.2NP_067374.2  B-cell lymphoma/leukemia 11B isoform b

      See identical proteins and their annotated locations for NP_067374.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame coding exon, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
      Source sequence(s)
      AC119219, AC119921, BQ745012, CV563304
      Consensus CDS
      CCDS36552.1
      UniProtKB/Swiss-Prot
      Q99PV8
      Related
      ENSMUSP00000105517.2, OTTMUSP00000021004, ENSMUST00000109891.2, OTTMUST00000046518
      Conserved Domains (4) summary
      sd00017
      Location:716736
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:356376
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:715736
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:728753
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      107910403..108004139 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244153.2XP_011242455.1  B-cell lymphoma/leukemia 11B isoform X3

      Conserved Domains (4) summary
      sd00017
      Location:787807
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:427447
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:786807
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:799824
      zf-H2C2_2; Zinc-finger double domain
    2. XM_006516111.3XP_006516174.1  B-cell lymphoma/leukemia 11B isoform X4

      Conserved Domains (4) summary
      sd00017
      Location:784804
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:424444
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:783804
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:796821
      zf-H2C2_2; Zinc-finger double domain
    3. XM_006516114.3XP_006516177.1  B-cell lymphoma/leukemia 11B isoform X7

      Conserved Domains (3) summary
      sd00017
      Location:715735
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:714735
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:727752
      zf-H2C2_2; Zinc-finger double domain
    4. XM_017315145.1XP_017170634.1  B-cell lymphoma/leukemia 11B isoform X8

    5. XM_017315144.1XP_017170633.1  B-cell lymphoma/leukemia 11B isoform X8

    6. XM_017315143.1XP_017170632.1  B-cell lymphoma/leukemia 11B isoform X6

    7. XM_006516110.3XP_006516173.1  B-cell lymphoma/leukemia 11B isoform X2

      Conserved Domains (3) summary
      sd00017
      Location:828848
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:827848
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:840865
      zf-H2C2_2; Zinc-finger double domain
    8. XM_011244152.2XP_011242454.1  B-cell lymphoma/leukemia 11B isoform X1

      Conserved Domains (3) summary
      sd00017
      Location:832852
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:831852
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:844869
      zf-H2C2_2; Zinc-finger double domain
    9. XM_006516113.3XP_006516176.1  B-cell lymphoma/leukemia 11B isoform X5

      Conserved Domains (3) summary
      sd00017
      Location:760780
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:759780
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:772797
      zf-H2C2_2; Zinc-finger double domain
    10. XM_006516116.2XP_006516179.1  B-cell lymphoma/leukemia 11B isoform X10

      Conserved Domains (4) summary
      sd00017
      Location:608628
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:248268
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:607628
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:620645
      zf-H2C2_2; Zinc-finger double domain
    11. XM_006516115.2XP_006516178.1  B-cell lymphoma/leukemia 11B isoform X9

      Conserved Domains (3) summary
      sd00017
      Location:657677
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:656677
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:669694
      zf-H2C2_2; Zinc-finger double domain
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