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    Mst1r macrophage stimulating 1 receptor (c-met-related tyrosine kinase) [ Mus musculus (house mouse) ]

    Gene ID: 19882, updated on 2-Jul-2017
    Official Symbol
    Mst1rprovided by MGI
    Official Full Name
    macrophage stimulating 1 receptor (c-met-related tyrosine kinase)provided by MGI
    Primary source
    MGI:MGI:99614
    See related
    Ensembl:ENSMUSG00000032584 Vega:OTTMUSG00000050789
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fv2; Ron; STK; Fv-2; PTK8; CD136; CDw136
    Summary
    This gene encodes a precursor protein that is proteolytically cleaved to yield an alpha chain and a beta chain which form a membrane-spanning heterodimer. The encoded protein belongs to a family of cell-surface receptor tyrosine kinases involved in signaling from the cell surface to the intracellular environment. The binding of the encoded protein to its ligand, macrophage-stimulating protein, mediates several biological activities including wound healing, tumor immunity, macrophage activation and hematopoiesis as well as cell growth, motility, survival and adhesion. The protein encoded by this gene also functions in early development and the macrophage-mediated inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
    Orthologs
    Location:
    9 59.07 cM; 9 F1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (107906858..107920383)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (107809220..107822714)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 6 Neighboring gene MON1 homolog A, secretory traffciking associated Neighboring gene actin-like 11 Neighboring gene CaM kinase-like vesicle-associated

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystemIntegrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligands...

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vacuole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    macrophage-stimulating protein receptor
    Names
    MSP receptor
    friend virus susceptibility 2
    p185-Ron
    receptor protein tyrosine kinase, c-met-related
    stem cell-derived tyrosine kinase
    NP_001274190.1
    NP_033100.2
    XP_006511717.1
    XP_006511718.1
    XP_006511719.1
    XP_006511721.1
    XP_017168707.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287261.1NP_001274190.1  macrophage-stimulating protein receptor isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the use of an alternate promoter, differs in the 5' UTR, lacks a significant portion of the 5' coding region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (2, also known as short-form Ron or SF-Ron or sf-Stk) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AL731808
      Conserved Domains (2) summary
      pfam07714
      Location:158414
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:162423
      PKc_like; Protein Kinases, catalytic domain
    2. NM_009074.2NP_033100.2  macrophage-stimulating protein receptor isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_033100.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1, also known as full-length Ron or FL-Ron).
      Source sequence(s)
      AL731808
      Consensus CDS
      CCDS23509.1
      UniProtKB/Swiss-Prot
      Q62190
      Related
      ENSMUSP00000035203.7, OTTMUSP00000069228, ENSMUST00000035203.8, OTTMUST00000128721
      Conserved Domains (7) summary
      cd11279
      Location:29525
      Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase
      smart00429
      Location:771863
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:686770
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:10631324
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      pfam01437
      Location:528567
      PSI; Plexin repeat
      pfam07714
      Location:10591315
      Pkinase_Tyr; Protein tyrosine kinase
      cl15674
      Location:571685
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    RNA

    1. NR_109782.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses two alternate splice sites compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK053655, AL731808
      Related
      ENSMUST00000195617.5, OTTMUST00000128722

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      107906858..107920383
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511658.3XP_006511721.1  macrophage-stimulating protein receptor isoform X5

      Conserved Domains (3) summary
      cd11279
      Location:29525
      Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase
      pfam01437
      Location:528567
      PSI; Plexin repeat
      cl15674
      Location:571685
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    2. XM_006511654.3XP_006511717.1  macrophage-stimulating protein receptor isoform X1

      Conserved Domains (7) summary
      cd11279
      Location:29525
      Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase
      smart00429
      Location:771864
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:686770
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:528567
      PSI; Plexin repeat
      pfam07714
      Location:10601343
      Pkinase_Tyr; Protein tyrosine kinase
      cl15674
      Location:571685
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
      cl21453
      Location:10641352
      PKc_like; Protein Kinases, catalytic domain
    3. XM_006511656.3XP_006511719.1  macrophage-stimulating protein receptor isoform X3

      Conserved Domains (7) summary
      cd11279
      Location:29525
      Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase
      smart00429
      Location:771864
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:686770
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:10641325
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      pfam01437
      Location:528567
      PSI; Plexin repeat
      pfam07714
      Location:10601316
      Pkinase_Tyr; Protein tyrosine kinase
      cl15674
      Location:571685
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    4. XM_006511655.3XP_006511718.1  macrophage-stimulating protein receptor isoform X2

      Conserved Domains (7) summary
      cd11279
      Location:29525
      Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase
      smart00429
      Location:771863
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:686770
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:528567
      PSI; Plexin repeat
      pfam07714
      Location:10591342
      Pkinase_Tyr; Protein tyrosine kinase
      cl15674
      Location:571685
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
      cl21453
      Location:10631351
      PKc_like; Protein Kinases, catalytic domain
    5. XM_017313218.1XP_017168707.1  macrophage-stimulating protein receptor isoform X4

    RNA

    1. XR_379756.3 RNA Sequence

    2. XR_379757.3 RNA Sequence

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