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    Bid BH3 interacting domain death agonist [ Mus musculus (house mouse) ]

    Gene ID: 12122, updated on 22-May-2018
    Official Symbol
    Bidprovided by MGI
    Official Full Name
    BH3 interacting domain death agonistprovided by MGI
    Primary source
    MGI:MGI:108093
    See related
    Ensembl:ENSMUSG00000004446 Vega:OTTMUSG00000024186
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI875481; AU022477; 2700049M22Rik
    Expression
    Ubiquitous expression in kidney adult (RPKM 20.6), thymus adult (RPKM 10.6) and 26 other tissues See more
    Orthologs
    See Bid in Genome Data Viewer
    Location:
    6 F1; 6 57.02 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (120893119..120917141, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (120843137..120866838, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 38889 Neighboring gene BCL2-like 13 (apoptosis facilitator) Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G1 pseudogene Neighboring gene microtubule associated monooxygenase, calponin and LIM domain containing 3 Neighboring gene predicted gene 9878 Neighboring gene predicted gene 4651

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic mitochondrial changes IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    establishment of protein localization to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hepatocyte apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mitochondrial ATP synthesis coupled electron transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrial outer membrane permeabilization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fibroblast apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitochondrial membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein oligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of release of cytochrome c from mitochondria IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein targeting to mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitochondrial membrane permeability involved in apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of protein oligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    release of cytochrome c from mitochondria IDA
    Inferred from Direct Assay
    more info
    PubMed 
    release of cytochrome c from mitochondria IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction in response to DNA damage TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion HDA PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    BH3-interacting domain death agonist
    Names
    p22 BID

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007544.4NP_031570.2  BH3-interacting domain death agonist

      See identical proteins and their annotated locations for NP_031570.2

      Status: VALIDATED

      Source sequence(s)
      AK077657, AK161235
      Consensus CDS
      CCDS20486.1
      UniProtKB/Swiss-Prot
      P70444
      Related
      ENSMUSP00000004560.5, OTTMUSP00000028756, ENSMUST00000004560.11
      Conserved Domains (1) summary
      pfam06393
      Location:3192
      BID; BH3 interacting domain (BID)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      120893119..120917141 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505411.3XP_006505474.1  BH3-interacting domain death agonist isoform X1

      See identical proteins and their annotated locations for XP_006505474.1

      UniProtKB/Swiss-Prot
      P70444
      Conserved Domains (1) summary
      pfam06393
      Location:3192
      BID; BH3 interacting domain (BID)
    2. XM_006505410.3XP_006505473.1  BH3-interacting domain death agonist isoform X1

      See identical proteins and their annotated locations for XP_006505473.1

      UniProtKB/Swiss-Prot
      P70444
      Conserved Domains (1) summary
      pfam06393
      Location:3192
      BID; BH3 interacting domain (BID)
    3. XM_006505409.2XP_006505472.1  BH3-interacting domain death agonist isoform X1

      See identical proteins and their annotated locations for XP_006505472.1

      UniProtKB/Swiss-Prot
      P70444
      Conserved Domains (1) summary
      pfam06393
      Location:3192
      BID; BH3 interacting domain (BID)

    Reference GRCm38.p4 129S1/SvImJ

    Genomic

    1. NT_039382.4 Reference GRCm38.p4 129S1/SvImJ

      Range
      517736..541471 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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