Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    TOR1 phosphatidylinositol kinase-related protein kinase TOR1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853529, updated on 20-Feb-2018
    Gene symbol
    TOR1
    Gene description
    phosphatidylinositol kinase-related protein kinase TOR1
    Primary source
    SGD:S000003827
    Locus tag
    YJR066W
    Gene type
    protein coding
    RNA name
    phosphatidylinositol kinase-related protein kinase TOR1
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DRR1
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (559416..566828)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene chaperonin-containing T-complex subunit CCT5 Neighboring gene actin-related protein 3 Neighboring gene Yae1p Neighboring gene replication factor C subunit 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • 3-phosphoinositide biosynthesis, organism-specific biosystem (from BIOCYC)
      3-phosphoinositide biosynthesis, organism-specific biosystem
      3-phosphoinositide biosynthesis
    • Autophagy - other, organism-specific biosystem (from KEGG)
      Autophagy - other, organism-specific biosystemAutophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either ...
    • Autophagy - other, conserved biosystem (from KEGG)
      Autophagy - other, conserved biosystemAutophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either ...
    • Autophagy - yeast, organism-specific biosystem (from KEGG)
      Autophagy - yeast, organism-specific biosystemAutophagy is a non-selective and bulk intracellular degradation system of eukaryotic cells and is highly conserved from yeast to human. In this process, the double-membrane vesicle, known as autophag...
    • Autophagy - yeast, conserved biosystem (from KEGG)
      Autophagy - yeast, conserved biosystemAutophagy is a non-selective and bulk intracellular degradation system of eukaryotic cells and is highly conserved from yeast to human. In this process, the double-membrane vesicle, known as autophag...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Longevity regulating pathway - multiple species, organism-specific biosystem (from KEGG)
      Longevity regulating pathway - multiple species, organism-specific biosystemAging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death. Despite the complexity of aging, rec...
    • Longevity regulating pathway - multiple species, conserved biosystem (from KEGG)
      Longevity regulating pathway - multiple species, conserved biosystemAging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death. Despite the complexity of aging, rec...
    • Mitophagy - yeast, organism-specific biosystem (from KEGG)
      Mitophagy - yeast, organism-specific biosystemMitophagy, which refers to the selective elimination of impaired or excessive mitochondria, is considered to be the main mechanism for mitochondria quality and quantity control. In yeast, oxidative s...
    • Mitophagy - yeast, conserved biosystem (from KEGG)
      Mitophagy - yeast, conserved biosystemMitophagy, which refers to the selective elimination of impaired or excessive mitochondria, is considered to be the main mechanism for mitochondria quality and quantity control. In yeast, oxidative s...
    • Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), organism-specific biosystem (from REACTOME)
      Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Nonsense-Mediated Decay (NMD), organism-specific biosystem (from REACTOME)
      Nonsense-Mediated Decay (NMD), organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • phosphatidylinositol phosphate biosynthesis, organism-specific biosystem (from BIOCYC)
      phosphatidylinositol phosphate biosynthesis, organism-specific biosystemThe phosphorylated products of phosphatidylinositol (PtdIns, PI), collectively referred to as phosphoinositides or phosphatidylinositol phosphates (PtdInsPs, PIPs), are membrane-bound lipids that fun...
    Products Interactant Other Gene Complex Source Pubs Description

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    TOR signaling IC
    Inferred by Curator
    more info
    PubMed 
    TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to heat IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    chronological cell aging IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    fungal-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondria-nucleus signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of autophagy IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    nucleolar large rRNA transcription by RNA polymerase I IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of snRNA pseudouridine synthesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of sphingolipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ribosome biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    translational initiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    TORC1 complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extrinsic component of cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
     
    vacuole IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    phosphatidylinositol kinase-related protein kinase TOR1
    NP_012600.1
    • PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      559416..566828
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181724.1NP_012600.1  TPA: phosphatidylinositol kinase-related protein kinase TOR1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012600.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P35169
      Conserved Domains (7) summary
      COG5032
      Location:2792470
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05169
      Location:20902366
      PIKKc_TOR; Catalytic domain of Target of Rapamycin
      pfam02260
      Location:24392470
      FATC; FATC domain
      pfam08771
      Location:19522049
      Rapamycin_bind; Rapamycin binding domain
      pfam11865
      Location:827986
      DUF3385; Domain of unknown function (DUF3385)
      pfam13513
      Location:771820
      HEAT_EZ; HEAT-like repeat
      sd00044
      Location:588620
      HEAT; HEAT repeat [structural motif]
    Support Center