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    gag-pol Gag-Pol [ Human immunodeficiency virus 1 ]

    Gene ID: 155348, updated on 5-Mar-2017
    Gene symbol
    gag-pol
    Gene description
    Gag-Pol
    Locus tag
    HIV1gp1
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Human immunodeficiency virus 1 (gb-acronym: HIV-1)
    Lineage
    Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; Lentivirus; Primate lentivirus group
    Sequence:
    NC_001802.1 (336..4642)

    NC_001802.1Genomic Context describing neighboring genes Neighboring gene Pr55(Gag) Neighboring gene p23 Neighboring gene p15 Neighboring gene p14 Neighboring gene p19 Neighboring gene p16 Neighboring gene gp160; envelope glycoprotein

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    ATP-citrate synthase isoform 1 ACLY complexes with PubMed
    long-chain-fatty-acid--CoA ligase 3 ACSL3 complexes with PubMed
    actin, cytoplasmic 1 ACTB complexes with PubMed
    double-stranded RNA-specific adenosine deaminase isoform b ADAR complexes with PubMed
    apoptosis-inducing factor 1, mitochondrial isoform AIF precursor AIFM1 complexes with PubMed
    delta-1-pyrroline-5-carboxylate synthase isoform 1 ALDH18A1 complexes with PubMed
    THO complex subunit 4 ALYREF complexes with PubMed
    AP-2 complex subunit mu isoform a AP2M1 complexes with PubMed
    AP-3 complex subunit delta-1 isoform 2 AP3D1 complexes with PubMed
    AP-3 complex subunit sigma-1 isoform 1 AP3S1 complexes with PubMed
    DNA dC->dU-editing enzyme APOBEC-3G isoform 1 APOBEC3G interacts with PubMed
    APOBEC3G interacts with PubMed
    ADP-ribosylation factor 4 ARF4 complexes with PubMed
    ADP-ribosylation factor 5 ARF5 complexes with PubMed
    ADP-ribosylation factor 6 ARF6 complexes with PubMed
    ADP-ribosylation factor-like protein 1 isoform 1 ARL1 complexes with PubMed
    actin-related protein 2/3 complex subunit 4 isoform a ARPC4 complexes with PubMed
    sodium/potassium-transporting ATPase subunit alpha-1 isoform a ATP1A1 complexes with PubMed
    ATP synthase subunit alpha, mitochondrial isoform a precursor ATP5A1 complexes with PubMed
    ATP synthase subunit gamma, mitochondrial isoform H (heart) precursor ATP5C1 complexes with PubMed
    ATP synthase subunit O, mitochondrial precursor ATP5O complexes with PubMed
    V-type proton ATPase subunit d 1 ATP6V0D1 complexes with PubMed
    CAD protein isoform 1 CAD complexes with PubMed
    calnexin precursor CANX complexes with PubMed
    caprin-1 isoform 1 CAPRIN1 complexes with PubMed
    T-complex protein 1 subunit beta isoform 1 CCT2 complexes with PubMed
    T-complex protein 1 subunit delta isoform a CCT4 complexes with PubMed
    cell division cycle 5-like protein CDC5L complexes with PubMed
    CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 1 CDIPT complexes with PubMed
    MHC class II transactivator isoform 2 CIITA upregulates PubMed
    clathrin light chain A isoform a CLTA incorporates PubMed
    clathrin light chain B isoform a CLTB incorporates PubMed
    clathrin heavy chain 1 isoform 1 CLTC complexes with PubMed
    CLTC incorporates PubMed
    coatomer subunit alpha isoform 2 COPA complexes with PubMed
    coatomer subunit zeta-1 isoform 1 COPZ1 complexes with PubMed
    copine-3 CPNE3 complexes with PubMed
    cleavage and polyadenylation specificity factor subunit 1 CPSF1 complexes with PubMed
    cleavage and polyadenylation specificity factor subunit 7 isoform 1 CPSF7 complexes with PubMed
    aspartate--tRNA ligase, cytoplasmic isoform 1 DARS complexes with PubMed
    dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit precursor DDOST complexes with PubMed
    ATP-dependent RNA helicase DDX1 DDX1 complexes with PubMed
    probable ATP-dependent RNA helicase DDX17 isoform 1 DDX17 regulated by PubMed
    DDX17 complexes with PubMed
    nucleolar RNA helicase 2 isoform 1 DDX21 complexes with PubMed
    probable ATP-dependent RNA helicase DDX23 DDX23 complexes with PubMed
    probable ATP-dependent RNA helicase DDX27 isoform 2 DDX27 complexes with PubMed
    spliceosome RNA helicase DDX39B DDX39B complexes with PubMed
    ATP-dependent RNA helicase DDX3X isoform 1 DDX3X complexes with PubMed
    probable ATP-dependent RNA helicase DDX5 isoform a DDX5 complexes with PubMed
    7-dehydrocholesterol reductase DHCR7 complexes with PubMed
    pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 DHX15 complexes with PubMed
    putative ATP-dependent RNA helicase DHX30 isoform 2 DHX30 complexes with PubMed
    ATP-dependent RNA helicase A DHX9 regulated by PubMed
    DHX9 complexes with PubMed
    dynamin-2 isoform 3 DNM2 complexes with PubMed
    developmentally-regulated GTP-binding protein 1 DRG1 complexes with PubMed
    elongation factor 1-alpha 1 EEF1A1 complexes with PubMed
    elongation factor 1-delta isoform 1 EEF1D complexes with PubMed
    elongation factor 1-gamma EEF1G complexes with PubMed
    eukaryotic translation initiation factor 3 subunit A EIF3A complexes with PubMed
    eukaryotic translation initiation factor 3 subunit D EIF3D complexes with PubMed
    eukaryotic translation initiation factor 3 subunit E EIF3E complexes with PubMed
    eukaryotic initiation factor 4A-I isoform 1 EIF4A1 complexes with PubMed
    eukaryotic initiation factor 4A-III EIF4A3 complexes with PubMed
    ELAV-like protein 1 ELAVL1 complexes with PubMed
    alpha-enolase isoform 1 ENO1 complexes with PubMed
    bifunctional glutamate/proline--tRNA ligase EPRS complexes with PubMed
    eukaryotic peptide chain release factor subunit 1 isoform 1 ETF1 modulated by PubMed
    electron transfer flavoprotein subunit beta isoform 1 ETFB complexes with PubMed
    fatty acid synthase FASN complexes with PubMed
    pre-mRNA 3'-end-processing factor FIP1 isoform 1 FIP1L1 complexes with PubMed
    filamin-A isoform 1 FLNA complexes with PubMed
    glyceraldehyde-3-phosphate dehydrogenase isoform 1 GAPDH interacts with PubMed
    GAPDH complexes with PubMed
    very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 HACD3 complexes with PubMed
    heterogeneous nuclear ribonucleoprotein A0 HNRNPA0 complexes with PubMed
    heterogeneous nuclear ribonucleoprotein A1 isoform a HNRNPA1 complexes with PubMed
    heterogeneous nuclear ribonucleoproteins A2/B1 isoform A2 HNRNPA2B1 complexes with PubMed
    heterogeneous nuclear ribonucleoprotein A3 isoform a HNRNPA3 complexes with PubMed
    heterogeneous nuclear ribonucleoprotein A/B isoform b HNRNPAB complexes with PubMed
    heterogeneous nuclear ribonucleoproteins C1/C2 isoform b HNRNPC complexes with PubMed
    heterogeneous nuclear ribonucleoprotein D0 isoform c HNRNPD complexes with PubMed
    heterogeneous nuclear ribonucleoprotein F HNRNPF complexes with PubMed
    heterogeneous nuclear ribonucleoprotein H HNRNPH1 complexes with PubMed
    heterogeneous nuclear ribonucleoprotein H2 HNRNPH2 complexes with PubMed
    heterogeneous nuclear ribonucleoprotein H3 isoform a HNRNPH3 complexes with PubMed
    heterogeneous nuclear ribonucleoprotein K isoform a HNRNPK complexes with PubMed
    heterogeneous nuclear ribonucleoprotein M isoform a HNRNPM complexes with PubMed
    heterogeneous nuclear ribonucleoprotein R isoform 2 HNRNPR complexes with PubMed
    heterogeneous nuclear ribonucleoprotein U isoform b HNRNPU complexes with PubMed
    peroxisomal multifunctional enzyme type 2 isoform 2 HSD17B4 complexes with PubMed
    heat shock protein HSP 90-alpha isoform 2 HSP90AA1 incorporates PubMed
    heat shock protein HSP 90-beta isoform a HSP90AB1 incorporates PubMed
    heat shock 70 kDa protein 1A HSPA1A complexes with PubMed
    heat shock 70 kDa protein 1B HSPA1B complexes with PubMed
    heat shock 70 kDa protein 1-like HSPA1L complexes with PubMed
    78 kDa glucose-regulated protein precursor HSPA5 complexes with PubMed
    heat shock cognate 71 kDa protein isoform 1 HSPA8 complexes with PubMed
    stress-70 protein, mitochondrial precursor HSPA9 complexes with PubMed
    60 kDa heat shock protein, mitochondrial HSPD1 complexes with PubMed
    E3 ubiquitin-protein ligase HUWE1 HUWE1 interacts with PubMed
    isoleucine--tRNA ligase, cytoplasmic IARS complexes with PubMed
    isocitrate dehydrogenase IDH3A complexes with PubMed
    insulin-like growth factor 2 mRNA-binding protein 1 isoform 1 IGF2BP1 complexes with PubMed
    insulin-like growth factor 2 mRNA-binding protein 3 IGF2BP3 complexes with PubMed
    interleukin enhancer-binding factor 2 isoform 1 ILF2 complexes with PubMed
    interleukin enhancer-binding factor 3 isoform b ILF3 complexes with PubMed
    alpha-internexin INA complexes with PubMed
    importin-7 IPO7 complexes with PubMed
    ras GTPase-activating-like protein IQGAP1 IQGAP1 complexes with PubMed
    lysine--tRNA ligase isoform 2 KARS associates with PubMed
    far upstream element-binding protein 2 KHSRP complexes with PubMed
    importin subunit beta-1 isoform 1 KPNB1 complexes with PubMed
    KRR1 small subunit processome component homolog KRR1 complexes with PubMed
    leucine--tRNA ligase, cytoplasmic isoform 1 LARS complexes with PubMed
    L-lactate dehydrogenase A chain isoform 1 LDHA complexes with PubMed
    L-lactate dehydrogenase B chain isoform LDHB LDHB complexes with PubMed
    leucine-rich PPR motif-containing protein, mitochondrial precursor LRPPRC complexes with PubMed
    leucine-rich repeat-containing protein 59 LRRC59 complexes with PubMed
    putative RNA-binding protein Luc7-like 2 isoform 1 LUC7L2 complexes with PubMed
    lysozyme C precursor LYZ complexes with PubMed
    matrin-3 isoform a MATR3 complexes with PubMed
    DNA replication licensing factor MCM7 isoform 1 MCM7 complexes with PubMed
    mannosyl-oligosaccharide glucosidase isoform 1 MOGS complexes with PubMed
    putative helicase MOV-10 isoform 1 MOV10 complexes with PubMed
    myb-binding protein 1A isoform 2 MYBBP1A complexes with PubMed
    nucleolin NCL complexes with PubMed
    NF-kappa-B-repressing factor isoform 2 NKRF complexes with PubMed
    non-POU domain-containing octamer-binding protein isoform 1 NONO complexes with PubMed
    nucleophosmin isoform 1 NPM1 complexes with PubMed
    vesicle-fusing ATPase NSF complexes with PubMed
    cleavage and polyadenylation specificity factor subunit 5 NUDT21 complexes with PubMed
    nuclear pore complex protein Nup155 isoform 2 NUP155 complexes with PubMed
    ornithine aminotransferase, mitochondrial isoform 1 precursor OAT complexes with PubMed
    polyadenylate-binding protein 1 PABPC1 complexes with PubMed
    polyadenylate-binding protein 4 isoform 2 PABPC4 complexes with PubMed
    polyadenylate-binding protein 2 PABPN1 complexes with PubMed
    poly(rC)-binding protein 1 PCBP1 complexes with PubMed
    pyruvate dehydrogenase E1 component subunit beta, mitochondrial isoform 1 precursor PDHB complexes with PubMed
    prohibitin isoform 1 PHB complexes with PubMed
    prohibitin-2 isoform 1 PHB2 complexes with PubMed
    pyruvate kinase PKM isoform a PKM complexes with PubMed
    plastin-3 isoform 1 PLS3 complexes with PubMed
    peroxiredoxin-6 PRDX6 complexes with PubMed
    DNA-dependent protein kinase catalytic subunit isoform 1 PRKDC complexes with PubMed
    pre-mRNA-processing factor 40 homolog A PRPF40A complexes with PubMed
    pre-mRNA-processing-splicing factor 8 PRPF8 complexes with PubMed
    26S protease regulatory subunit 10B PSMC6 complexes with PubMed
    26S proteasome non-ATPase regulatory subunit 2 isoform 1 PSMD2 complexes with PubMed
    pentatricopeptide repeat domain-containing protein 3, mitochondrial precursor PTCD3 complexes with PubMed
    phosphatidylserine synthase 1 isoform 1 PTDSS1 complexes with PubMed
    glycogen phosphorylase, liver form isoform 1 PYGL complexes with PubMed
    ras-related protein Rab-10 RAB10 complexes with PubMed
    ras-related protein Rab-5C isoform a RAB5C complexes with PubMed
    ras-related protein Rab-8A RAB8A complexes with PubMed
    receptor of activated protein C kinase 1 RACK1 complexes with PubMed
    GTP-binding nuclear protein Ran isoform 1 RAN complexes with PubMed
    ribonucleoprotein PTB-binding 1 RAVER1 complexes with PubMed
    RNA-binding motif protein, X chromosome isoform 1 RBMX complexes with PubMed
    E3 ubiquitin-protein ligase BRE1A RNF20 complexes with PubMed
    60S ribosomal protein L10 isoform a RPL10 complexes with PubMed
    60S ribosomal protein L13 isoform 1 RPL13 complexes with PubMed
    60S ribosomal protein L14 RPL14 complexes with PubMed
    60S ribosomal protein L17 isoform a RPL17 complexes with PubMed
    60S ribosomal protein L18 isoform 1 RPL18 complexes with PubMed
    60S ribosomal protein L19 isoform 1 RPL19 complexes with PubMed
    60S ribosomal protein L24 RPL24 complexes with PubMed
    60S ribosomal protein L29 RPL29 complexes with PubMed
    60S ribosomal protein L3 isoform a RPL3 complexes with PubMed
    60S ribosomal protein L4 RPL4 complexes with PubMed
    60S ribosomal protein L5 RPL5 complexes with PubMed
    60S ribosomal protein L6 isoform 1 RPL6 complexes with PubMed
    60S ribosomal protein L7 RPL7 complexes with PubMed
    60S ribosomal protein L7a RPL7A complexes with PubMed
    60S ribosomal protein L8 RPL8 complexes with PubMed
    60S ribosomal protein L9 RPL9 complexes with PubMed
    60S acidic ribosomal protein P0 RPLP0 complexes with PubMed
    dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 precursor RPN1 complexes with PubMed
    40S ribosomal protein S2 RPS2 complexes with PubMed
    40S ribosomal protein S3 isoform 1 RPS3 complexes with PubMed
    40S ribosomal protein S4, X isoform X isoform RPS4X complexes with PubMed
    40S ribosomal protein S6 RPS6 complexes with PubMed
    40S ribosomal protein S8 RPS8 complexes with PubMed
    40S ribosomal protein S9 isoform a RPS9 complexes with PubMed
    ras-related GTP-binding protein A RRAGA complexes with PubMed
    scaffold attachment factor B1 isoform 3 SAFB complexes with PubMed
    U4/U6.U5 tri-snRNP-associated protein 1 SART1 complexes with PubMed
    protein transport protein Sec61 subunit alpha isoform 1 SEC61A1 complexes with PubMed
    serpin H1 precursor SERPINH1 complexes with PubMed
    splicing factor 3B subunit 1 isoform 1 SF3B1 complexes with PubMed
    splicing factor 3B subunit 2 SF3B2 complexes with PubMed
    splicing factor 3B subunit 4 SF3B4 complexes with PubMed
    splicing factor, proline- and glutamine-rich SFPQ complexes with PubMed
    sideroflexin-1 isoform 1 SFXN1 complexes with PubMed
    mitochondrial 2-oxoglutarate/malate carrier protein isoform 1 SLC25A11 complexes with PubMed
    ADP/ATP translocase 2 SLC25A5 complexes with PubMed
    structural maintenance of chromosomes protein 1A isoform 1 SMC1A complexes with PubMed
    U5 small nuclear ribonucleoprotein 200 kDa helicase SNRNP200 complexes with PubMed
    spectrin alpha chain, non-erythrocytic 1 isoform 2 SPTAN1 complexes with PubMed
    signal recognition particle subunit SRP68 isoform 1 SRP68 complexes with PubMed
    signal recognition particle subunit SRP72 isoform 1 SRP72 complexes with PubMed
    signal recognition particle receptor subunit beta SRPRB complexes with PubMed
    serine/arginine-rich splicing factor 1 isoform 1 SRSF1 complexes with PubMed
    serine/arginine-rich splicing factor 10 isoform 1 SRSF10 complexes with PubMed
    serine/arginine-rich splicing factor 4 SRSF4 complexes with PubMed
    serine/arginine-rich splicing factor 7 isoform 1 SRSF7 complexes with PubMed
    double-stranded RNA-binding protein Staufen homolog 1 isoform a STAU1 complexes with PubMed
    heterogeneous nuclear ribonucleoprotein Q isoform 1 SYNCRIP complexes with PubMed
    RISC-loading complex subunit TARBP2 isoform b TARBP2 interacts with PubMed
    TAR DNA-binding protein 43 TARDBP complexes with PubMed
    T-complex protein 1 subunit alpha isoform a TCP1 complexes with PubMed
    THO complex subunit 2 THOC2 complexes with PubMed
    transcription intermediary factor 1-beta TRIM28 complexes with PubMed
    tubulin alpha-1A chain isoform 1 TUBA1A complexes with PubMed
    tubulin alpha-4A chain isoform 1 TUBA4A complexes with PubMed
    regulator of nonsense transcripts 1 isoform 2 UPF1 complexes with PubMed
    regulator of nonsense transcripts 3B isoform 2 UPF3B complexes with PubMed
    vimentin VIM complexes with PubMed
    nuclease-sensitive element-binding protein 1 YBX1 complexes with PubMed
    zinc finger RNA-binding protein ZFR complexes with PubMed
    A-kinase anchor protein 8-like isoform 1 AKAP8L incorporates PubMed
    anaphase-promoting complex subunit 2 ANAPC2 interacts with PubMed
    DNA dC->dU-editing enzyme APOBEC-3F isoform a APOBEC3F interacts with PubMed
    beta-arrestin-2 isoform 1 ARRB2 interacts with PubMed
    autophagy-related protein 16-1 isoform 2 ATG16L1 interacts with PubMed
    autophagy-related protein 16-2 isoform 1 ATG16L2 interacts with PubMed
    cell cycle and apoptosis regulator protein 2 CCAR2 interacts with PubMed
    T-cell surface glycoprotein CD8 alpha chain isoform 1 precursor CD8A inhibits PubMed
    T-cell surface glycoprotein CD8 beta chain isoform 5 precursor CD8B inhibits PubMed
    CLTA stabilized by PubMed
    CLTB stabilized by PubMed
    CLTC stabilized by PubMed
    EIF3A interacts with PubMed
    eukaryotic translation initiation factor 3 subunit B EIF3B interacts with PubMed
    eukaryotic translation initiation factor 3 subunit C isoform a EIF3C interacts with PubMed
    EIF3D interacts with PubMed
    EIF3E interacts with PubMed
    eukaryotic translation initiation factor 3 subunit F EIF3F interacts with PubMed
    eukaryotic translation initiation factor 3 subunit G EIF3G interacts with PubMed
    eukaryotic translation initiation factor 3 subunit H EIF3H interacts with PubMed
    eukaryotic translation initiation factor 3 subunit I EIF3I interacts with PubMed
    eukaryotic translation initiation factor 3 subunit K isoform 1 EIF3K interacts with PubMed
    eukaryotic translation initiation factor 3 subunit L isoform 1 EIF3L interacts with PubMed
    ferrochelatase, mitochondrial isoform b precursor FECH interacts with PubMed
    growth factor receptor-bound protein 2 isoform 1 GRB2 interacts with PubMed
    HLA class I histocompatibility antigen, A-1 alpha chain A*03:01:0:01 precursor HLA-A binds PubMed
    HSPD1 interacts with PubMed
    IDH3A interacts with PubMed
    interleukin-10 precursor IL10 regulated by PubMed
    IPO7 interacts with PubMed
    KARS interacts with PubMed
    KARS binds PubMed
    galectin-3-binding protein precursor LGALS3BP interacts with PubMed
    LIM domain-containing protein 1 LIMD1 interacts with PubMed
    DNA replication licensing factor MCM4 MCM4 interacts with PubMed
    DNA replication licensing factor MCM6 MCM6 interacts with PubMed
    MCM7 interacts with PubMed
    NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform 1 NFU1 interacts with PubMed
    nuclear migration protein nudC NUDC interacts with PubMed
    oxysterol-binding protein-related protein 3 isoform a OSBPL3 interacts with PubMed
    protein disulfide-isomerase A4 precursor PDIA4 interacts with PubMed
    protein disulfide-isomerase A6 isoform d precursor PDIA6 interacts with PubMed
    protein pelota homolog PELO interacts with PubMed
    POU domain, class 2, transcription factor 1 isoform 1 POU2F1 interacts with PubMed
    POU domain, class 2, transcription factor 2 isoform 2 POU2F2 interacts with PubMed
    serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CB interacts with PubMed
    PC4 and SFRS1-interacting protein isoform 1 PSIP1 recruits PubMed
    PSIP1 interacts with PubMed
    reticulocalbin-1 precursor RCN1 interacts with PubMed
    ATP-dependent DNA helicase Q1 RECQL interacts with PubMed
    ribonucleoside-diphosphate reductase subunit M2 isoform 2 RRM2 interacts with PubMed
    ruvB-like 1 isoform 1 RUVBL1 interacts with PubMed
    transcription factor Sp1 isoform b SP1 interacts with PubMed
    transcription factor Sp3 isoform 1 SP3 interacts with PubMed
    transcription factor PU.1 isoform 2 SPI1 interacts with PubMed
    succinate--CoA ligase SUCLG2 interacts with PubMed
    5,6-dihydroxyindole-2-carboxylic acid oxidase precursor TYRP1 interacts with PubMed
    peroxisomal leader peptide-processing protease isoform a TYSND1 interacts with PubMed
    E3 ubiquitin-protein ligase UBR2 isoform 1 UBR2 interacts with PubMed
    E3 ubiquitin-protein ligase UBR4 UBR4 interacts with PubMed
    multidrug resistance protein 1 isoform 2 ABCB1 interacts with PubMed
    disintegrin and metalloproteinase domain-containing protein 10 isoform 1 preproprotein ADAM10 co-localizes with PubMed
    alkaline phosphatase, placental type preproprotein ALPP interacts with PubMed
    ANKRD13C: ankyrin repeat domain 13C ANKRD13C interacts with PubMed
    APOBEC3F interacts with PubMed
    APOBEC3G binds PubMed
    APOBEC3G interacts with PubMed
    APOBEC3G interacts with PubMed
    APOBEC3G complexes with PubMed
    serine-protein kinase ATM ATM interacts with PubMed
    ATM interacts with PubMed
    V-type proton ATPase subunit G 3 isoform a ATP6V1G3 interacts with PubMed
    serine/threonine-protein kinase ATR ATR interacts with PubMed
    transcription regulator protein BACH2 BACH2 interacts with PubMed
    barrier-to-autointegration factor BANF1 interacts with PubMed
    BANF1 interacts with PubMed
    transcription factor BTF3 isoform B BTF3 binds PubMed
    uncharacterized protein C15orf57 isoform 2 C15orf57 binds PubMed
    C2 domain-containing protein 3 isoform 2 C2CD3 interacts with PubMed
    cullin-associated NEDD8-dissociated protein 2 isoform 2 CAND2 interacts with PubMed
    CCT4 binds PubMed
    cell division cycle-associated 7-like protein isoform 1 CDCA7L co-localizes with PubMed
    CDCA7L binds PubMed
    CDCA7L overlaps PubMed
    CDCA7L binds PubMed
    cyclin-dependent kinase inhibitor 1 isoform 1 CDKN1A complexes with PubMed
    choline/ethanolaminephosphotransferase 1 CEPT1 interacts with PubMed
    probable cytosolic iron-sulfur protein assembly protein CIAO1 CIAO1 interacts with PubMed
    cytoskeleton-associated protein 5 isoform b CKAP5 interacts with PubMed
    creatine kinase U-type, mitochondrial isoform 1 precursor CKMT1A interacts with PubMed
    creatine kinase U-type, mitochondrial precursor CKMT1B interacts with PubMed
    CLTA incorporates PubMed
    CLTA incorporates PubMed
    CLTB incorporates PubMed
    CLTB incorporates PubMed
    CLTC incorporates PubMed
    CLTC incorporates PubMed
    CREB-binding protein isoform a CREBBP interacts with PubMed
    beta-crystallin S CRYGS interacts with PubMed
    exportin-2 isoform 1 CSE1L binds PubMed
    cystatin-C precursor CST3 interacts with PubMed
    interleukin-8 precursor CXCL8 interacts with PubMed
    CXCL8 interacts with PubMed
    death domain-associated protein 6 isoform a DAXX interacts with PubMed
    DAXX interacts with PubMed
    probable ATP-dependent RNA helicase DDX6 DDX6 interacts with PubMed
    desmoplakin isoform I DSP interacts with PubMed
    dynein light chain 1, cytoplasmic DYNLL1 interacts with PubMed
    DYNLL1 interacts with PubMed
    DYNLL1 interacts with PubMed
    DYNLL1 interacts with PubMed
    polycomb protein EED isoform a EED binds PubMed
    EED interacts with PubMed
    EED stimulated by PubMed
    EEF1A1 interacts with PubMed
    EEF1A1 binds PubMed
    EEF1A1 binds PubMed
    EEF1G interacts with PubMed
    eIF-2-alpha kinase GCN2 EIF2AK4 binds PubMed
    EIF3H binds PubMed
    emerin EMD interacts with PubMed
    histone acetyltransferase p300 EP300 acetylated by PubMed
    EP300 acetylated by PubMed
    mitotic spindle-associated MMXD complex subunit MIP18 FAM96B interacts with PubMed
    tumor necrosis factor receptor superfamily member 6 isoform 1 precursor FAS interacts with PubMed
    flap endonuclease 1 FEN1 stimulates PubMed
    fibrous sheath-interacting protein 1 FSIP1 interacts with PubMed
    gem-associated protein 2 isoform alpha GEMIN2 interacts with PubMed
    GEMIN2 interacts with PubMed
    GEMIN2 binds PubMed
    histone H2AX H2AFX induces phosphorylation of PubMed
    histone deacetylase 1 HDAC1 complexes with PubMed
    HDAC1 complexes with PubMed
    HD domain-containing protein 2 HDDC2 interacts with PubMed
    hepatoma-derived growth factor-related protein 2 isoform 2 HDGFRP2 activated by PubMed
    HDGFRP2 interacts with PubMed
    HDGFRP2 interacts with PubMed
    HDGFRP2 co-localizes with PubMed
    HEAT repeat-containing protein 1 HEATR1 interacts with PubMed
    high mobility group protein HMG-I/HMG-Y isoform b HMGA1 stimulated by PubMed
    non-histone chromosomal protein HMG-17 HMGN2 binds PubMed
    HNRNPA2B1 binds PubMed
    HNRNPM interacts with PubMed
    heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform a HNRNPUL1 interacts with PubMed
    HORMA domain-containing protein 2 isoform a HORMAD2 interacts with PubMed
    HSPD1 stimulated by PubMed
    10 kDa heat shock protein, mitochondrial HSPE1 interacts with PubMed
    HUWE1 interacts with PubMed
    zinc finger protein Aiolos isoform 1 IKZF3 interacts with PubMed
    interleukin-15 isoform 1 preproprotein IL15 enhanced by PubMed
    interleukin-1 beta proprotein IL1B interacts with PubMed
    interleukin-2 precursor IL2 enhanced by PubMed
    interleukin-4 isoform 1 precursor IL4 enhanced by PubMed
    interleukin-7 isoform 1 precursor IL7 interacts with PubMed
    IL7 enhanced by PubMed
    importin-4 IPO4 interacts with PubMed
    importin-5 IPO5 imported by PubMed
    IPO5 binds PubMed
    IPO5 imported by PubMed
    IPO7 binds PubMed
    IPO7 imported by PubMed
    protein IWS1 homolog IWS1 binds PubMed
    IWS1 displaces PubMed
    IWS1 overlaps PubMed
    histone acetyltransferase KAT2A KAT2A binds PubMed
    KAT2A acetylated by PubMed
    histone acetyltransferase KAT6A isoform 1 KAT6A acetylated by PubMed
    histone acetyltransferase KAT6B isoform 1 KAT6B acetylated by PubMed
    histone acetyltransferase KAT7 isoform 1 KAT7 acetylated by PubMed
    histone acetyltransferase KAT8 isoform 1 KAT8 acetylated by PubMed
    BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 KCTD13 interacts with PubMed
    dyslexia-associated protein KIAA0319-like protein KIAA0319L interacts with PubMed
    kinesin-associated protein 3 isoform 1 KIFAP3 binds PubMed
    histone-lysine N-methyltransferase 2A isoform 1 precursor KMT2A binds PubMed
    importin subunit alpha-5 KPNA1 interacts with PubMed
    KPNA1 complexes with PubMed
    KPNA1 imported by PubMed
    KPNA1 binds PubMed
    KPNA1 imported by PubMed
    importin subunit alpha-1 KPNA2 imported by PubMed
    KPNA2 interacts with PubMed
    KPNA2 interacts with PubMed
    KPNA2 complexes with PubMed
    KPNA2 imported by PubMed
    KPNA2 binds PubMed
    importin subunit alpha-4 KPNA3 imported by PubMed
    KPNA3 interacts with PubMed
    KPNA3 complexes with PubMed
    KPNA3 imported by PubMed
    KPNA3 binds PubMed
    importin subunit alpha-3 KPNA4 binds PubMed
    KPNA4 interacts with PubMed
    KPNA4 binds PubMed
    KPNA4 complexes with PubMed
    KPNA4 imported by PubMed
    KPNA4 binds PubMed
    KPNA4 imported by PubMed
    importin subunit alpha-6 KPNA5 interacts with PubMed
    KPNA5 complexes with PubMed
    KPNA5 imported by PubMed
    KPNA5 binds PubMed
    KPNA5 imported by PubMed
    importin subunit alpha-7 KPNA6 imported by PubMed
    KPNA6 imported by PubMed
    KPNA6 binds PubMed
    KPNB1 interacts with PubMed
    KPNB1 imported by PubMed
    KPNB1 binds PubMed
    KPNB1 imported by PubMed
    LRPPRC associates with PubMed
    mitogen-activated protein kinase 1 MAPK1 interacts with PubMed
    mitogen-activated protein kinase 8 isoform beta2 MAPK8 phosphorylated by PubMed
    MCM6 interacts with PubMed
    MKL/myocardin-like protein 2 isoform 2 MKL2 interacts with PubMed
    interferon-induced GTP-binding protein Mx2 MX2 interacts with PubMed
    NACHT, LRR and PYD domains-containing protein 3 isoform a NLRP3 interacts with PubMed
    nuclear pore complex protein Nup153 isoform 2 NUP153 interacts with PubMed
    NUP153 interacts with PubMed
    NUP153 interacts with PubMed
    NUP153 binds PubMed
    nuclear pore glycoprotein p62 NUP62 binds PubMed
    nuclear pore complex protein Nup98-Nup96 isoform 1 proprotein NUP98 cooperates with PubMed
    nuclear transport factor 2 NUTF2 inhibited by PubMed
    succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial precursor OXCT1 interacts with PubMed
    polyadenylate-binding protein 1-like PABPC1L interacts with PubMed
    poly PARP1 requires PubMed
    phosphoenolpyruvate carboxykinase, cytosolic PCK1 binds PubMed
    PDIA4 interacts with PubMed
    peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 PIN1 binds PubMed
    PIN1 binds PubMed
    plakophilin-4 isoform a PKP4 interacts with PubMed
    procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 isoform 2 precursor PLOD1 interacts with PubMed
    procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform 2 precursor PLOD2 interacts with PubMed
    protein PML isoform 1 PML interacts with PubMed
    pogo transposable element with ZNF domain isoform 1 POGZ binds PubMed
    POGZ overlaps PubMed
    POGZ displaces PubMed
    POGZ competes with PubMed
    peptidyl-prolyl cis-trans isomerase A isoform 1 PPIA incorporates PubMed
    PRKDC interacts with PubMed
    PRKDC interacts with PubMed
    PSIP1 binds PubMed
    PSIP1 binds PubMed
    PSIP1 binds PubMed
    PSIP1 overlaps PubMed
    PSIP1 interacts with PubMed
    PSIP1 co-localizes with PubMed
    PSIP1 stimulated by PubMed
    PSIP1 fractionates with PubMed
    PSIP1 interacts with PubMed
    PSIP1 interacts with PubMed
    PSIP1 binds PubMed
    PSIP1 interacts with PubMed
    PSIP1 binds PubMed
    PSIP1 interacts with PubMed
    PSIP1 interacts with PubMed
    PSIP1 binds PubMed
    PSIP1 competes with PubMed
    PSIP1 stabilized by PubMed
    PSIP1 binds PubMed
    PSIP1 interacts with PubMed
    PSIP1 binds PubMed
    PSIP1 interacts with PubMed
    PSIP1 binds PubMed
    PSIP1 induces accumulation of PubMed
    PSIP1 binds PubMed
    PSIP1 interacts with PubMed
    PSIP1 complexes with PubMed
    PSIP1 interacts with PubMed
    PSIP1 interacts with PubMed
    PSIP1 interacts with PubMed
    PSIP1 binds PubMed
    PSIP1 interacts with PubMed
    PSIP1 interacts with PubMed
    PSIP1 upregulates PubMed
    PSIP1 interacts with PubMed
    PSIP1 binds PubMed
    PSIP1 inhibited by PubMed
    PSIP1 imported by PubMed
    PSIP1 interacts with PubMed
    PSIP1 interacts with PubMed
    PSIP1 binds PubMed
    PSIP1 binds PubMed
    PSIP1 binds PubMed
    PSIP1 binds PubMed
    PSIP1 regulated by PubMed
    PSIP1 binds PubMed
    PSIP1 interacts with PubMed
    PSIP1 complexes with PubMed
    PSIP1 complexes with PubMed
    PSIP1 interacts with PubMed
    PSIP1 interacts with PubMed
    PSIP1 complexes with PubMed
    PSIP1 complexes with PubMed
    PSIP1 complexes with PubMed
    PSIP1 interacts with PubMed
    PSIP1 interacts with PubMed
    PSIP1 interacts with PubMed
    PSIP1 interacts with PubMed
    proteasome subunit alpha type-1 isoform 2 PSMA1 degraded by PubMed
    proteasome subunit alpha type-2 PSMA2 degraded by PubMed
    proteasome subunit alpha type-3 isoform 1 PSMA3 degraded by PubMed
    proteasome subunit alpha type-4 isoform 1 PSMA4 degraded by PubMed
    proteasome subunit alpha type-5 isoform 1 PSMA5 degraded by PubMed
    proteasome subunit alpha type-6 isoform a PSMA6 degraded by PubMed
    proteasome subunit alpha type-7 PSMA7 degraded by PubMed
    proteasome subunit beta type-1 PSMB1 degraded by PubMed
    proteasome subunit beta type-10 precursor PSMB10 degraded by PubMed
    proteasome subunit beta type-2 isoform 1 PSMB2 degraded by PubMed
    proteasome subunit beta type-3 PSMB3 degraded by PubMed
    proteasome subunit beta type-4 PSMB4 degraded by PubMed
    proteasome subunit beta type-5 isoform 1 PSMB5 degraded by PubMed
    proteasome subunit beta type-6 isoform 1 precursor PSMB6 degraded by PubMed
    proteasome subunit beta type-7 precursor PSMB7 degraded by PubMed
    proteasome subunit beta type-8 isoform E1 precursor PSMB8 degraded by PubMed
    proteasome subunit beta type-9 precursor PSMB9 degraded by PubMed
    26S protease regulatory subunit 4 isoform a PSMC1 degraded by PubMed
    26S protease regulatory subunit 7 isoform 1 PSMC2 degraded by PubMed
    26S protease regulatory subunit 6A PSMC3 degraded by PubMed
    26S protease regulatory subunit 6B isoform 1 PSMC4 degraded by PubMed
    26S protease regulatory subunit 8 isoform 1 PSMC5 degraded by PubMed
    PSMC6 degraded by PubMed
    26S proteasome non-ATPase regulatory subunit 1 isoform 1 PSMD1 degraded by PubMed
    26S proteasome non-ATPase regulatory subunit 10 isoform 1 PSMD10 degraded by PubMed
    26S proteasome non-ATPase regulatory subunit 11 PSMD11 degraded by PubMed
    26S proteasome non-ATPase regulatory subunit 12 isoform 1 PSMD12 degraded by PubMed
    26S proteasome non-ATPase regulatory subunit 13 isoform 1 PSMD13 degraded by PubMed
    PSMD2 degraded by PubMed
    26S proteasome non-ATPase regulatory subunit 3 PSMD3 degraded by PubMed
    26S proteasome non-ATPase regulatory subunit 4 isoform 2 PSMD4 degraded by PubMed
    26S proteasome non-ATPase regulatory subunit 5 isoform 1 PSMD5 degraded by PubMed
    26S proteasome non-ATPase regulatory subunit 6 isoform 2 PSMD6 degraded by PubMed
    26S proteasome non-ATPase regulatory subunit 7 PSMD7 degraded by PubMed
    26S proteasome non-ATPase regulatory subunit 8 PSMD8 degraded by PubMed
    26S proteasome non-ATPase regulatory subunit 9 isoform 1 PSMD9 degraded by PubMed
    proteasome activator complex subunit 1 isoform 1 PSME1 degraded by PubMed
    proteasome activator complex subunit 2 PSME2 degraded by PubMed
    proteasome activator complex subunit 3 isoform 1 PSME3 degraded by PubMed
    proteasome activator complex subunit 4 PSME4 degraded by PubMed
    proteasome inhibitor PI31 subunit isoform 1 PSMF1 degraded by PubMed
    E3 ubiquitin-protein ligase RAD18 RAD18 interacts with PubMed
    DNA repair protein RAD51 homolog 1 isoform 1 RAD51 inhibited by PubMed
    RAD51 inhibited by PubMed
    RAN inhibited by PubMed
    E3 SUMO-protein ligase RanBP2 RANBP2 interacts with PubMed
    ran-binding protein 6 isoform 1 RANBP6 interacts with PubMed
    ran-binding protein 9 RANBP9 binds PubMed
    putative RNA-binding protein 15B RBM15B interacts with PubMed
    ret finger protein-like 3 isoform 2 RFPL3 interacts with PubMed
    60S ribosomal protein L23 RPL23 binds PubMed
    histone deacetylase complex subunit SAP18 SAP18 binds PubMed
    SAP18 binds PubMed
    paired amphipathic helix protein Sin3a SIN3A recruits PubMed
    zinc transporter 7 SLC30A7 interacts with PubMed
    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform a SMARCB1 interacts with PubMed
    SMARCB1 inhibited by PubMed
    SMARCB1 complexes with PubMed
    SMARCB1 interacts with PubMed
    SMARCB1 binds PubMed
    SMARCB1 stimulated by PubMed
    SMARCB1 binds PubMed
    SMARCB1 interacts with PubMed
    SMARCB1 interacts with PubMed
    SMARCB1 recruits PubMed
    SMARCB1 interacts with PubMed
    SMARCB1 inhibited by PubMed
    SMARCB1 binds PubMed
    SMARCB1 stimulated by PubMed
    CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform a precursor ST8SIA4 interacts with PubMed
    signal transducer and activator of transcription 5B STAT5B interacts with PubMed
    stathmin isoform a STMN1 binds PubMed
    SUCLG2 interacts with PubMed
    small ubiquitin-related modifier 1 isoform a precursor SUMO1 sumoylated by PubMed
    SUMO1 interacts with PubMed
    small ubiquitin-related modifier 2 isoform a precursor SUMO2 sumoylated by PubMed
    SUMO2 interacts with PubMed
    small ubiquitin-related modifier 3 isoform 1 precursor SUMO3 sumoylated by PubMed
    tyrosyl-DNA phosphodiesterase 2 TDP2 interacts with PubMed
    thyroid hormone receptor-associated protein 3 isoform 1 THRAP3 binds PubMed
    tumor necrosis factor ligand superfamily member 13B isoform 1 TNFSF13B interacts with PubMed
    transportin-1 isoform 1 TNPO1 imported by PubMed
    TNPO1 binds PubMed
    TNPO1 imported by PubMed
    transportin-3 isoform 1 TNPO3 binds PubMed
    TNPO3 binds PubMed
    TNPO3 interacts with PubMed
    TNPO3 binds PubMed
    TNPO3 binds PubMed
    TNPO3 binds PubMed
    TNPO3 complexes with PubMed
    cellular tumor antigen p53 isoform a TP53 induces phosphorylation of PubMed
    trafficking protein particle complex subunit 10 TRAPPC10 interacts with PubMed
    TRIM28 inhibited by PubMed
    TRIM28 interacts with PubMed
    TUBA1A interacts with PubMed
    tubulin alpha-1B chain TUBA1B interacts with PubMed
    tubulin alpha-1C chain isoform c TUBA1C interacts with PubMed
    tubulin alpha-3C/D chain TUBA3C interacts with PubMed
    TUBA3D interacts with PubMed
    tubulin alpha-3E chain TUBA3E interacts with PubMed
    TUBA4A interacts with PubMed
    tubulin alpha-8 chain isoform 1 TUBA8 interacts with PubMed
    TYSND1 interacts with PubMed
    ubiquitin-like modifier-activating enzyme 1 UBA1 interacts with PubMed
    ubiquitin-conjugating enzyme E2 D2 isoform 1 UBE2D2 interacts with PubMed
    SUMO-conjugating enzyme UBC9 UBE2I interacts with PubMed
    protein unc-45 homolog A isoform 2 UNC45A interacts with PubMed
    uracil-DNA glycosylase isoform UNG2 UNG incorporates PubMed
    UNG binds PubMed
    prefoldin subunit 3 isoform 1 VBP1 binds PubMed
    WD repeat-containing protein 61 isoform a WDR61 interacts with PubMed
    X-ray repair cross-complementing protein 5 XRCC5 associates with PubMed
    XRCC5 interacts with PubMed
    X-ray repair cross-complementing protein 6 isoform 1 XRCC6 stabilized by PubMed
    XRCC6 binds PubMed
    XRCC6 associates with PubMed
    XRCC6 interacts with PubMed
    14-3-3 protein beta/alpha YWHAB interacts with PubMed
    14-3-3 protein epsilon YWHAE interacts with PubMed
    14-3-3 protein gamma YWHAG interacts with PubMed
    14-3-3 protein zeta/delta YWHAZ interacts with PubMed
    transcriptional repressor protein YY1 YY1 binds PubMed
    alpha-2-macroglobulin isoform a precursor A2M cleaves PubMed
    actin, alpha skeletal muscle ACTA1 cleaves PubMed
    ACTA1 cleaves PubMed
    actin, aortic smooth muscle ACTA2 cleaves PubMed
    ACTA2 cleaves PubMed
    ACTB cleaves PubMed
    ACTB cleaves PubMed
    actin, alpha cardiac muscle 1 precursor ACTC1 cleaves PubMed
    ACTC1 cleaves PubMed
    actin, cytoplasmic 2 ACTG1 cleaves PubMed
    ACTG1 cleaves PubMed
    actin, gamma-enteric smooth muscle isoform 1 precursor ACTG2 cleaves PubMed
    ACTG2 cleaves PubMed
    alpha-actinin-1 isoform b ACTN1 cleaves PubMed
    adenosylhomocysteinase isoform 1 AHCY interacts with PubMed
    A-kinase anchor protein 8 AKAP8 cleaves PubMed
    A-kinase anchor protein 9 isoform 2 AKAP9 interacts with PubMed
    A-kinase-interacting protein 1 isoform a AKIP1 interacts with PubMed
    fructose-bisphosphate aldolase A isoform 1 ALDOA cleaves PubMed
    Alstrom syndrome protein 1 ALMS1 interacts with PubMed
    AMP deaminase 2 isoform 1 AMPD2 cleaves PubMed
    anaphase-promoting complex subunit 1 ANAPC1 interacts with PubMed
    ANAPC2 interacts with PubMed
    acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 1 ANP32E cleaves PubMed
    amyloid beta A4 protein isoform a precursor APP cleaves PubMed
    rho guanine nucleotide exchange factor 12 isoform 1 ARHGEF12 interacts with PubMed
    ARRB2 interacts with PubMed
    ATP5A1 cleaves PubMed
    apoptosis regulator BAX isoform beta BAX interacts with PubMed
    BAX cleaves PubMed
    apoptosis regulator Bcl-2 alpha isoform BCL2 interacts with PubMed
    BCL2 cleaves PubMed
    BCL2 downregulates PubMed
    protein bicaudal D homolog 2 isoform 2 BICD2 interacts with PubMed
    BH3-interacting domain death agonist isoform 1 BID induces cleavage of PubMed
    protein BUD31 homolog BUD31 cleaves PubMed
    ashwin isoform 1 C2orf49 cleaves PubMed
    carbonic anhydrase 12 isoform 1 precursor CA12 cleaves PubMed
    calmodulin CALM1 cleaves PubMed
    histone-arginine methyltransferase CARM1 CARM1 interacts with PubMed
    caspase-3 preproprotein CASP3 cleaves PubMed
    CASP3 activates PubMed
    caspase-8 isoform A precursor CASP8 cleaves PubMed
    CASP8 activates PubMed
    caspase-9 isoform alpha precursor CASP9 activates PubMed
    coiled-coil and C2 domain-containing protein 1A CC2D1A cleaves PubMed
    CCAR2 interacts with PubMed
    coiled-coil domain-containing protein 43 isoform 1 CCDC43 cleaves PubMed
    C-C chemokine receptor type 10 CCR10 cleaves PubMed
    CDC5L cleaves PubMed
    CIITA cooperates with PubMed
    casein kinase II subunit alpha isoform a CSNK2A1 phosphorylated by PubMed
    casein kinase II subunit alpha' CSNK2A2 phosphorylated by PubMed
    casein kinase II subunit beta isoform 1 CSNK2B phosphorylated by PubMed
    CST3 inhibited by PubMed
    CST3 interacts with PubMed
    transcriptional repressor CTCF isoform 1 CTCF cleaves PubMed
    catenin beta-1 isoform 1 CTNNB1 cleaves PubMed
    cytochrome c CYCS interacts with PubMed
    CYCS induces release of PubMed
    DDX17 cleaves PubMed
    ATP-dependent RNA helicase DDX18 DDX18 cleaves PubMed
    DDX5 cleaves PubMed
    probable ATP-dependent RNA helicase DDX58 DDX58 relocalizes PubMed
    desmin DES cleaves PubMed
    DNA fragmentation factor subunit alpha isoform 1 DFFA induces cleavage of PubMed
    DNA fragmentation factor subunit beta isoform 2 DFFB induces cleavage of PubMed
    putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform 1 DHX16 cleaves PubMed
    protein diaphanous homolog 1 isoform 1 DIAPH1 cleaves PubMed
    DIAPH1 interacts with PubMed
    dihydrolipoyl dehydrogenase, mitochondrial isoform 1 precursor DLD cleaves PubMed
    dnaJ homolog subfamily C member 7 isoform 1 DNAJC7 cleaves PubMed
    dnaJ homolog subfamily C member 8 DNAJC8 cleaves PubMed
    deoxyhypusine hydroxylase DOHH interacts with PubMed
    docking protein 1 isoform a DOK1 interacts with PubMed
    deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform 2 DUT cleaves PubMed
    probable rRNA-processing protein EBP2 isoform 2 EBNA1BP2 cleaves PubMed
    eukaryotic translation elongation factor 1 epsilon-1 isoform 1 EEF1E1 cleaves PubMed
    EEF1G cleaves PubMed
    elongation factor 2 EEF2 cleaves PubMed
    EIF2AK4 cleaves PubMed
    EIF2AK4 cleaves PubMed
    EIF3A interacts with PubMed
    EIF3B interacts with PubMed
    EIF3C interacts with PubMed
    EIF3D cleaves PubMed
    EIF3D cleaves PubMed
    EIF3D interacts with PubMed
    EIF3E interacts with PubMed
    EIF3F interacts with PubMed
    EIF3H interacts with PubMed
    EIF3K interacts with PubMed
    EIF3L interacts with PubMed
    eukaryotic translation initiation factor 3 subunit M isoform 1 EIF3M interacts with PubMed
    eukaryotic initiation factor 4A-II EIF4A2 cleaves PubMed
    eukaryotic translation initiation factor 4 gamma 1 isoform 5 EIF4G1 cleaves PubMed
    eukaryotic translation initiation factor 5A-1 isoform B EIF5A cleaves PubMed
    echinoderm microtubule-associated protein-like 3 isoform 3 EML3 interacts with PubMed
    ENO1 cleaves PubMed
    epiplakin EPPK1 interacts with PubMed
    S-formylglutathione hydrolase ESD cleaves PubMed
    peptidyl-prolyl cis-trans isomerase FKBP4 FKBP4 cleaves PubMed
    FKBP4 interacts with PubMed
    FAD synthase isoform 1 FLAD1 interacts with PubMed
    folliculin isoform 1 FLCN interacts with PubMed
    FLNA cleaves PubMed
    filamin-B isoform 2 FLNB cleaves PubMed
    filamin-C isoform a FLNC cleaves PubMed
    fibronectin isoform 1 precursor FN1 cleaves PubMed
    folliculin-interacting protein 1 isoform 1 FNIP1 interacts with PubMed
    forkhead box protein C1 FOXC1 interacts with PubMed
    cyclin-G-associated kinase isoform 1 GAK interacts with PubMed
    glial fibrillary acidic protein isoform 1 GFAP cleaves PubMed
    glutaredoxin 2 isoform 1 GLRX2 activated by PubMed
    glutaredoxin-related protein 5, mitochondrial precursor GLRX5 activated by PubMed
    guanine nucleotide-binding protein-like 3 isoform 1 GNL3 cleaves PubMed
    golgin subfamily A member 1 GOLGA1 interacts with PubMed
    probable G-protein coupled receptor 25 GPR25 cleaves PubMed
    glutathione reductase, mitochondrial isoform 1 precursor GSR cleaves PubMed
    E3 ubiquitin-protein ligase HERC2 HERC2 interacts with PubMed
    protein HGH1 homolog HGH1 interacts with PubMed
    HNRNPA1 cleaves PubMed
    HNRNPA2B1 cleaves PubMed
    heterogeneous nuclear ribonucleoprotein L isoform a HNRNPL cleaves PubMed
    HNRNPU cleaves PubMed
    HSP90AA1 cleaves PubMed
    HSP90AB1 cleaves PubMed
    HSPD1 cleaves PubMed
    HUWE1 cleaves PubMed
    intraflagellar transport protein 122 homolog isoform 3 IFT122 interacts with PubMed
    IL1B cleaves PubMed
    integrin alpha-3 preproprotein ITGA3 cleaves PubMed
    integrin beta-4 isoform 1 precursor ITGB4 cleaves PubMed
    KARS inhibited by PubMed
    potassium channel subfamily K member 6 KCNK6 cleaves PubMed
    BTB/POZ domain-containing protein KCTD7 isoform 1 KCTD7 cleaves PubMed
    KRR1 cleaves PubMed
    plastin-2 LCP1 cleaves PubMed
    leucine-rich repeat-containing G-protein coupled receptor 6 isoform 2 LGR6 cleaves PubMed
    LIMD1 interacts with PubMed
    microtubule-associated protein 1A MAP1A cleaves PubMed
    microtubule-associated proteins 1A/1B light chain 3A isoform a MAP1LC3A cleaves PubMed
    microtubule-associated proteins 1A/1B light chain 3B MAP1LC3B cleaves PubMed
    microtubule-associated proteins 1A/1B light chain 3C MAP1LC3C cleaves PubMed
    microtubule-associated protein 2 isoform 1 MAP2 cleaves PubMed
    induced myeloid leukemia cell differentiation protein Mcl-1 isoform 1 MCL1 interacts with PubMed
    DNA replication licensing factor MCM5 MCM5 cleaves PubMed
    malate dehydrogenase, mitochondrial isoform 1 precursor MDH2 cleaves PubMed
    DNA mismatch repair protein Msh2 isoform 1 MSH2 interacts with PubMed
    protein LYRIC MTDH cleaved by PubMed
    myosin-10 isoform 2 MYH10 cleaves PubMed
    myosin-11 isoform SM1A MYH11 cleaves PubMed
    myosin-13 MYH13 cleaves PubMed
    myosin-14 isoform 2 MYH14 cleaves PubMed
    myosin-6 MYH6 cleaves PubMed
    myosin-7 MYH7 cleaves PubMed
    myosin-9 MYH9 cleaves PubMed
    nuclear prelamin A recognition factor isoform a NARF interacts with PubMed
    nuclear autoantigenic sperm protein isoform 2 NASP cleaves PubMed
    protein NDRG1 isoform 1 NDRG1 cleaves PubMed
    nuclear factor of activated T-cells 5 isoform c NFAT5 interacts with PubMed
    nuclear factor NF-kappa-B p105 subunit isoform 1 NFKB1 cleaves PubMed
    NFU1 interacts with PubMed
    nuclear transcription factor Y subunit alpha isoform 1 NFYA cleaves PubMed
    H/ACA ribonucleoprotein complex subunit 2 isoform a NHP2 cleaves PubMed
    MKI67 FHA domain-interacting nucleolar phosphoprotein NIFK cleaves PubMed
    NKRF cleaves PubMed
    NONO cleaves PubMed
    puromycin-sensitive aminopeptidase isoform 1 NPEPPS cleaves PubMed
    nuclear mitotic apparatus protein 1 isoform 1 NUMA1 cleaves PubMed
    OSBPL3 interacts with PubMed
    oxysterol-binding protein-related protein 6 isoform a OSBPL6 interacts with PubMed
    OTU domain-containing protein 6B isoform 1 OTUD6B cleaves PubMed
    proliferation-associated protein 2G4 PA2G4 cleaves PubMed
    PABPC1 cleaves PubMed
    PABPC1 cleaves PubMed
    polyadenylate-binding protein 3 PABPC3 cleaves PubMed
    PABPC4 cleaves PubMed
    polyadenylate-binding protein 5 PABPC5 cleaves PubMed
    PARP1 cleaves PubMed
    PARP1 cleaves PubMed
    PARP1 induces cleavage of PubMed
    PARP4 interacts with PubMed
    PARP4 cleaves PubMed
    PARP4 induces cleavage of PubMed
    protocadherin gamma-A6 isoform 1 precursor PCDHGA6 cleaves PubMed
    protein disulfide-isomerase A3 precursor PDIA3 cleaves PubMed
    phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform 1 PHKA1 cleaves PubMed
    phosphorylase b kinase regulatory subunit alpha, liver isoform PHKA2 cleaves PubMed
    phosphorylase b kinase regulatory subunit beta isoform a PHKB cleaves PubMed
    elafin preproprotein PI3 inhibited by PubMed
    PKM cleaves PubMed
    plastin-1 PLS1 cleaves PubMed
    PLS3 cleaves PubMed
    phosphomannomutase 2 PMM2 cleaves PubMed
    DNA polymerase epsilon catalytic subunit A POLE interacts with PubMed
    DNA polymerase epsilon subunit 3 POLE3 interacts with PubMed
    DNA polymerase epsilon subunit 4 POLE4 interacts with PubMed
    POTE ankyrin domain family member F POTEF cleaves PubMed
    platelet basic protein preproprotein PPBP cleaves PubMed
    PPIA cleaves PubMed
    peptidyl-prolyl cis-trans isomerase H isoform 1 PPIH cleaves PubMed
    peroxiredoxin-1 PRDX1 cleaves PubMed
    peroxiredoxin-2 PRDX2 cleaves PubMed
    protein kinase C alpha type PRKCA inhibited by PubMed
    protein kinase C beta type isoform 2 PRKCB inhibited by PubMed
    protein kinase C delta type PRKCD inhibited by PubMed
    protein kinase C epsilon type PRKCE inhibited by PubMed
    protein kinase C gamma type isoform 2 PRKCG inhibited by PubMed
    protein kinase C eta type PRKCH inhibited by PubMed
    protein kinase C iota type PRKCI inhibited by PubMed
    protein kinase C theta type isoform 1 PRKCQ inhibited by PubMed
    protein kinase C zeta type isoform 1 PRKCZ inhibited by PubMed
    serine/threonine-protein kinase PRP4 homolog PRPF4B cleaves PubMed
    PSIP1 cleaves PubMed
    PSMA6 cleaves PubMed
    PSMB9 cleaves PubMed
    PSMC4 cleaves PubMed
    polypyrimidine tract-binding protein 1 isoform a PTBP1 cleaves PubMed
    pumilio homolog 2 isoform 1 PUM2 interacts with PubMed
    protein quaking isoform 1 QKI cleaves PubMed
    RNA-binding protein 28 isoform 1 RBM28 cleaves PubMed
    RNA-binding protein 8A RBM8A cleaves PubMed
    regulator of chromosome condensation isoform c RCC1 cleaves PubMed
    protein RCC2 RCC2 cleaves PubMed
    receptor-interacting serine/threonine-protein kinase 1 isoform 2 RIPK1 disrupts PubMed
    RIPK1 cleaves PubMed
    RIPK1 cleaves PubMed
    RIPK1 binds PubMed
    receptor-interacting serine/threonine-protein kinase 2 RIPK2 cleaves PubMed
    RIPK2 binds PubMed
    ribonuclease inhibitor RNH1 cleaves PubMed
    RPL10 cleaves PubMed
    60S ribosomal protein L18a RPL18A cleaves PubMed
    RPL23 cleaves PubMed
    RPL3 cleaves PubMed
    60S ribosomal protein L30 RPL30 cleaves PubMed
    60S ribosomal protein L35 RPL35 cleaves PubMed
    RPL5 cleaves PubMed
    RPL6 cleaves PubMed
    RPL7 cleaves PubMed
    RPL9 cleaves PubMed
    40S ribosomal protein S17 RPS17 cleaves PubMed
    40S ribosomal protein S19 isoform 1 RPS19 cleaves PubMed
    40S ribosomal protein S23 RPS23 cleaves PubMed
    40S ribosomal protein S24 isoform c RPS24 cleaves PubMed
    40S ribosomal protein S3a isoform 1 RPS3A cleaves PubMed
    40S ribosomal protein S7 RPS7 cleaves PubMed
    ribosome biogenesis regulatory protein homolog RRS1 cleaves PubMed
    serine--tRNA ligase, cytoplasmic isoform a SARS interacts with PubMed
    SART1 cleaves PubMed
    plasma protease C1 inhibitor precursor SERPING1 cleaves PubMed
    splicing factor 3A subunit 3 isoform 1 SF3A3 interacts with PubMed
    SF3B2 cleaves PubMed
    ADP/ATP translocase 1 SLC25A4 cleaves PubMed
    antileukoproteinase precursor SLPI enhanced by PubMed
    SLPI inhibited by PubMed
    probable global transcription activator SNF2L2 isoform a SMARCA2 cleaves PubMed
    telomerase-binding protein EST1A isoform 1 SMG6 interacts with PubMed
    staphylococcal nuclease domain-containing protein 1 SND1 cleaves PubMed
    SNW domain-containing protein 1 isoform 2 SNW1 cleaves PubMed
    spindlin-2A SPIN2A cleaves PubMed
    spectrin alpha chain, erythrocytic 1 SPTA1 cleaves PubMed
    SPTA1 cleaves PubMed
    SPTAN1 cleaves PubMed
    spectrin beta chain, erythrocytic isoform b SPTB cleaves PubMed
    spectrin beta chain, non-erythrocytic 1 isoform 1 SPTBN1 cleaves PubMed
    spectrin beta chain, non-erythrocytic 2 SPTBN2 cleaves PubMed
    spectrin beta chain, non-erythrocytic 4 isoform sigma1 SPTBN4 cleaves PubMed
    spectrin beta chain, non-erythrocytic 5 SPTBN5 cleaves PubMed
    SRP72 cleaves PubMed
    serine/arginine repetitive matrix protein 1 isoform 2 SRRM1 cleaves PubMed
    lupus La protein SSB cleaves PubMed
    Sjoegren syndrome/scleroderma autoantigen 1 isoform 1 SSSCA1 interacts with PubMed
    serine/threonine-protein kinase 38 STK38 cleaves PubMed
    serine/threonine-protein kinase 38-like STK38L cleaves PubMed
    switch-associated protein 70 isoform 1 SWAP70 cleaves PubMed
    THRAP3 cleaves PubMed
    mitochondrial import inner membrane translocase subunit Tim10 TIMM10 cleaves PubMed
    transketolase isoform 1 TKT cleaves PubMed
    talin-1 TLN1 cleaves PubMed
    talin-2 TLN2 cleaves PubMed
    troponin C, slow skeletal and cardiac muscles TNNC1 cleaves PubMed
    troponin C, skeletal muscle TNNC2 cleaves PubMed
    mitochondrial import receptor subunit TOM22 homolog TOMM22 interacts with PubMed
    TOMM22 cleaves PubMed
    tropomyosin alpha-1 chain isoform Tpm1.5cy TPM1 degrades PubMed
    TPM1 cleaves PubMed
    tropomyosin beta chain isoform Tpm2.2st TPM2 degrades PubMed
    tropomyosin alpha-3 chain isoform Tpm3.12st TPM3 degrades PubMed
    zinc finger transcription factor Trps1 isoform 1 TRPS1 interacts with PubMed
    GDP-L-fucose synthase isoform 2 TSTA3 cleaves PubMed
    TUBA1B cleaves PubMed
    elongation factor Tu, mitochondrial precursor TUFM cleaves PubMed
    UPF1 cleaves PubMed
    VBP1 interacts with PubMed
    voltage-dependent anion-selective channel protein 1 VDAC1 cleaves PubMed
    VDAC1 interacts with PubMed
    VIM cleaves PubMed
    VIM cleaves PubMed
    VIM cleaves PubMed
    VIM degrades PubMed
    VIM cleaves PubMed
    wiskott-Aldrich syndrome protein WAS cleaves PubMed
    YWHAE cleaves PubMed
    YY1 cleaves PubMed
    zinc finger CCCH-type antiviral protein 1 isoform 1 ZC3HAV1 cleaves PubMed
    CAAX prenyl protease 1 homolog ZMPSTE24 interacts with PubMed
    zinc finger protein 202 isoform 1 ZNF202 cleaves PubMed
    zinc finger protein 292 ZNF292 cleaves PubMed
    zinc finger protein 598 ZNF598 cleaves PubMed
    ACTA1 interacts with PubMed
    ACTA1 co-localizes with PubMed
    ACTA2 interacts with PubMed
    ACTA2 co-localizes with PubMed
    ACTB co-localizes with PubMed
    ACTB binds PubMed
    ACTC1 interacts with PubMed
    ACTC1 co-localizes with PubMed
    ACTG1 interacts with PubMed
    ACTG1 co-localizes with PubMed
    ACTG2 interacts with PubMed
    ACTG2 co-localizes with PubMed
    double-stranded RNA-specific adenosine deaminase isoform a ADAR inhibited by PubMed
    A-kinase anchor protein 1, mitochondrial precursor AKAP1 binds PubMed
    AKAP8L associates with PubMed
    APOBEC3F inhibited by PubMed
    APOBEC3F interacts with PubMed
    APOBEC3G binds PubMed
    APOBEC3G interacts with PubMed
    APOBEC3G inhibited by PubMed
    APOBEC3G inhibited by PubMed
    APOBEC3G inhibited by PubMed
    APOBEC3G binds PubMed
    APOBEC3G interacts with PubMed
    APOBEC3G activates PubMed
    APOBEC3G interacts with PubMed
    ATG16L1 interacts with PubMed
    ATG16L2 interacts with PubMed
    caveolin-1 isoform alpha CAV1 inhibited by PubMed
    cyclin-T1 isoform b CCNT1 inhibited by PubMed
    cyclin-dependent kinase inhibitor 2A isoform p16INK4a CDKN2A inhibited by PubMed
    CLTA incorporates PubMed
    CLTB incorporates PubMed
    CLTC incorporates PubMed
    cleavage and polyadenylation specificity factor subunit 6 isoform 1 CPSF6 inhibited by PubMed
    granulocyte-macrophage colony-stimulating factor precursor CSF2 interacts with PubMed
    CSNK2A1 phosphorylated by PubMed
    CSNK2A1 stimulated by PubMed
    CSNK2A2 phosphorylated by PubMed
    CSNK2A2 stimulated by PubMed
    CSNK2B phosphorylated by PubMed
    CSNK2B stimulated by PubMed
    CXCL8 interacts with PubMed
    DHX9 regulated by PubMed
    cytoplasmic dynein 1 heavy chain 1 DYNC1H1 regulated by PubMed
    cytoplasmic dynein 2 heavy chain 1 isoform 1 DYNC2H1 regulated by PubMed
    DYNLL1 interacts with PubMed
    DYNLL1 interacts with PubMed
    ELAVL1 interacts with PubMed
    ELAVL1 interacts with PubMed
    ELAVL1 interacts with PubMed
    synaptic functional regulator FMR1 isoform ISO1 FMR1 associates with PubMed
    GEMIN2 stimulated by PubMed
    GRB2 interacts with PubMed
    hepatitis A virus cellular receptor 1 isoform a precursor HAVCR1 inhibited by PubMed
    hepatitis A virus cellular receptor 2 precursor HAVCR2 inhibited by PubMed
    HAVCR2 inhibited by PubMed
    histone deacetylase 4 HDAC4 regulated by PubMed
    HDGFRP2 interacts with PubMed
    HSPD1 interacts with PubMed
    intercellular adhesion molecule 1 precursor ICAM1 interacts with PubMed
    interferon alpha-1/13 precursor IFNA1 inhibited by PubMed
    IFNA1 inhibited by PubMed
    interferon alpha-10 precursor IFNA10 inhibited by PubMed
    IFNA10 inhibited by PubMed
    IFNA13 inhibited by PubMed
    IFNA13 inhibited by PubMed
    interferon alpha-14 precursor IFNA14 inhibited by PubMed
    IFNA14 inhibited by PubMed
    interferon alpha-16 precursor IFNA16 inhibited by PubMed
    IFNA16 inhibited by PubMed
    interferon alpha-17 precursor IFNA17 inhibited by PubMed
    IFNA17 inhibited by PubMed
    interferon alpha-2 precursor IFNA2 inhibited by PubMed
    IFNA2 inhibited by PubMed
    interferon alpha-21 precursor IFNA21 inhibited by PubMed
    IFNA21 inhibited by PubMed
    interferon alpha-4 precursor IFNA4 inhibited by PubMed
    IFNA4 inhibited by PubMed
    interferon alpha-5 precursor IFNA5 inhibited by PubMed
    IFNA5 inhibited by PubMed
    interferon alpha-6 precursor IFNA6 inhibited by PubMed
    IFNA6 inhibited by PubMed
    interferon alpha-7 precursor IFNA7 inhibited by PubMed
    IFNA7 inhibited by PubMed
    interferon alpha-8 precursor IFNA8 inhibited by PubMed
    IFNA8 inhibited by PubMed
    interferon beta precursor IFNB1 upregulates PubMed
    interferon gamma precursor IFNG degraded by PubMed
    IL10 inhibited by PubMed
    interleukin-12 subunit alpha precursor IL12A downregulated by PubMed
    interleukin-12 subunit beta precursor IL12B downregulated by PubMed
    interleukin-13 precursor IL13 inhibited by PubMed
    IL1B interacts with PubMed
    IPO7 interacts with PubMed
    IPO7 imported by PubMed
    interferon regulatory factor 3 isoform 1 IRF3 activates PubMed
    KARS interacts with PubMed
    lactoperoxidase isoform 1 preproprotein LPO inhibited by PubMed
    lactotransferrin isoform 1 preproprotein LTF inhibited by PubMed
    dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 interacts with PubMed
    MAPK1 interacts with PubMed
    mitogen-activated protein kinase 12 isoform 1 MAPK12 interacts with PubMed
    mitogen-activated protein kinase 3 isoform 1 MAPK3 interacts with PubMed
    cyclic GMP-AMP synthase MB21D1 cooperates with PubMed
    NCL fractionates with PubMed
    nuclear factor of activated T-cells, cytoplasmic 1 isoform B NFATC1 enhanced by PubMed
    nuclear factor of activated T-cells, cytoplasmic 2 isoform B NFATC2 enhanced by PubMed
    NLRP3 interacts with PubMed
    nucleoside diphosphate kinase A isoform b NME1 complexes with PubMed
    phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform 1 PIK3C2A phosphorylated by PubMed
    PPIA enhanced by PubMed
    PRKCA phosphorylated by PubMed
    protein kinase C beta type isoform 1 PRKCB phosphorylated by PubMed
    PRKCD phosphorylated by PubMed
    PRKCE phosphorylated by PubMed
    PRKCG phosphorylated by PubMed
    PRKCH phosphorylated by PubMed
    PRKCI phosphorylated by PubMed
    PRKCQ phosphorylated by PubMed
    PRKCZ phosphorylated by PubMed
    PSMB8 degraded by PubMed
    protein-tyrosine kinase 2-beta isoform a PTK2B interacts with PubMed
    PTK2B interacts with PubMed
    ras-related protein Rab-11A isoform 1 RAB11A interacts with PubMed
    ras-related protein Rab-7a RAB7A interacts with PubMed
    replication protein A 70 kDa DNA-binding subunit RPA1 inhibited by PubMed
    replication protein A 32 kDa subunit isoform 1 RPA2 inhibited by PubMed
    replication protein A 14 kDa subunit RPA3 inhibited by PubMed
    replication protein A 30 kDa subunit RPA4 inhibited by PubMed
    deoxynucleoside triphosphate triphosphohydrolase SAMHD1 SAMHD1 regulated by PubMed
    SAMHD1 regulated by PubMed
    SAMHD1 regulated by PubMed
    Na(+)/H(+) exchange regulatory cofactor NHE-RF1 SLC9A3R1 interacts with PubMed
    proto-oncogene tyrosine-protein kinase Src SRC interacts with PubMed
    syntaxin-binding protein 2 isoform a STXBP2 regulated by PubMed
    trimethylguanosine synthase isoform 1 TGS1 enhances PubMed
    TIMD4: T-cell immunoglobulin and mucin domain containing 4 (TIM-4) TIMD4 inhibited by PubMed
    toll-like receptor 7 precursor TLR7 inhibited by PubMed
    DNA topoisomerase 1 TOP1 enhanced by PubMed
    TOP1 enhanced by PubMed
    DNA topoisomerase 2-alpha TOP2A co-localizes with PubMed
    DNA topoisomerase 2-beta isoform 2 TOP2B co-localizes with PubMed
    TP53 interacts with PubMed
    tumor susceptibility gene 101 protein TSG101 inhibited by PubMed
    EEF1A1 interacts with PubMed
    EEF1G interacts with PubMed
    ICAM1 interacts with PubMed

    Go to the HIV-1, Human Interaction Database

    • 2-LTR circle formation, organism-specific biosystem (from REACTOME)
      2-LTR circle formation, organism-specific biosystemThe formation of 2-LTR circles requires the action of the cellular non-homologous DNA end-joining pathway. Specifically the cellular Ku, XRCC4 and ligase IV proteins are needed. Evidence for this i...
    • APOBEC3G mediated resistance to HIV-1 infection, organism-specific biosystem (from REACTOME)
      APOBEC3G mediated resistance to HIV-1 infection, organism-specific biosystemRepresentatives of the apolipoprotein B mRNA editing enzyme catalytic polypeptide 3 (APOBEC3) family provide innate resistance to exogeneous and endogenous retroviruses (see Cullen 2006 for a recent ...
    • Assembly Of The HIV Virion, organism-specific biosystem (from REACTOME)
      Assembly Of The HIV Virion, organism-specific biosystemVirion assembly packages all the components required for infectivity. These steps include two copies of the positive sense genomic viral RNA, cellular tRNALys, the viral envelope (Env) protein, the G...
    • Autointegration results in viral DNA circles, organism-specific biosystem (from REACTOME)
      Autointegration results in viral DNA circles, organism-specific biosystemIn this pathway, the viral integration machinery uses a site within the viral DNA as an integration target. This results in a covalent rearrangment of the viral DNA. The resulting DNA forms are no...
    • Binding and entry of HIV virion, organism-specific biosystem (from REACTOME)
      Binding and entry of HIV virion, organism-specific biosystemHIV enters cells by fusion at the cell surface, that results in a productive infection. The envelope (Env) protein of HIV mediates entry. Env is composed of a surface subunit, gp120, and a transmemb...
    • Budding and maturation of HIV virion, organism-specific biosystem (from REACTOME)
      Budding and maturation of HIV virion, organism-specific biosystemWith the virus components precariously assembled on the inner leaflet of the plasma membrane, the host cell machinery is required for viral budding. The virus takes advantage of the host ESCRT pathwa...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Early Phase of HIV Life Cycle, organism-specific biosystem (from REACTOME)
      Early Phase of HIV Life Cycle, organism-specific biosystemIn the early phase of HIV lifecycle, an active virion binds and enters a target cell mainly by specific interactions of the viral envelope proteins with host cell surface receptors. The virion core...
    • HIV Infection, organism-specific biosystem (from REACTOME)
      HIV Infection, organism-specific biosystemThe global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million ...
    • HIV Life Cycle, organism-specific biosystem (from REACTOME)
      HIV Life Cycle, organism-specific biosystemThe life cycle of HIV-1 is divided into early and late phases, shown schematically in the figure. In the early phase, an HIV-1 virion binds to receptors and co-receptors on the human host cell surfac...
    • Host Interactions of HIV factors, organism-specific biosystem (from REACTOME)
      Host Interactions of HIV factors, organism-specific biosystemLike all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewis...
    • Infectious disease, organism-specific biosystem (from REACTOME)
      Infectious disease, organism-specific biosystem
      Infectious disease
    • Integration of provirus, organism-specific biosystem (from REACTOME)
      Integration of provirus, organism-specific biosystemFor retroviral DNA to direct production of progeny virions it must become covalently integrated into the host cell chromosome (reviewed in Coffin et al. 1997; Hansen et al. 1998). Analyses of mutants...
    • Integration of viral DNA into host genomic DNA, organism-specific biosystem (from REACTOME)
      Integration of viral DNA into host genomic DNA, organism-specific biosystemFollowing nuclear entry, the viral preintegration complex (PIC) must select a site for integration in a host cell chromosome, and then carry out the chemical steps of the reaction. At the chromosomal...
    • Interactions of Vpr with host cellular proteins, organism-specific biosystem (from REACTOME)
      Interactions of Vpr with host cellular proteins, organism-specific biosystemVpr has been implicated in multiple processes during HIV-1 replication, including nuclear import of the pre-integration complex (PIC)(Heinzinger et al., 1994), apoptosis (Stewart et al., 1997) and in...
    • Late Phase of HIV Life Cycle, organism-specific biosystem (from REACTOME)
      Late Phase of HIV Life Cycle, organism-specific biosystemThe late phase of the HIV-1 life cycle includes the regulated expression of the HIV gene products and the assembly of viral particles. The assembly of viral particles will be covered in a later relea...
    • Minus-strand DNA synthesis, organism-specific biosystem (from REACTOME)
      Minus-strand DNA synthesis, organism-specific biosystemIn the first part of reverse transcription, minus-strand synthesis, a DNA strand complementary to the HIV genomic RNA is synthesized, using the viral RNA as a template and a host cell lysine tRNA mol...
    • Plus-strand DNA synthesis, organism-specific biosystem (from REACTOME)
      Plus-strand DNA synthesis, organism-specific biosystemTwo specific polypurine tracts (PPT sequences) in the viral RNA, one within the pol gene (central or cPPT) and one immediately preceding the U3 sequence (3' PPT), are spared from degradation during m...
    • Reverse Transcription of HIV RNA, organism-specific biosystem (from REACTOME)
      Reverse Transcription of HIV RNA, organism-specific biosystemThe RNA genome of HIV-1, like that of other retroviruses, is reverse-transcribed (Baltimore 1970; Temin and Mizutani 1970) into double-stranded DNA, which is then integrated into a host cell chromoso...
    • Uncoating of the HIV Virion, organism-specific biosystem (from REACTOME)
      Uncoating of the HIV Virion, organism-specific biosystemHIV-1 uncoating is a poorly understood process. It likely involves a progressive and partial dissembly of matrix and capsid layers. While viral proteins like MA and Nef are thought to be involved, t...
    • Vpr-mediated nuclear import of PICs, organism-specific biosystem (from REACTOME)
      Vpr-mediated nuclear import of PICs, organism-specific biosystemVpr appears to function in anchoring the PIC to the nuclear envelope. This anchoring likely involves interactions between Vpr and host nucleoporins.
    Products Interactant Other Gene Complex Source Pubs Description
    Names
    Gag-Pol
    Gag-Pol polyprotein
    Gag-Pol Transframe peptide
    aspartic peptidase
    p66 subunit
    integrase
    reverse transcriptase p51 subunit
    Pol
    NP_057849.4
    • Pr160

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001802.1 Reference assembly

      Range
      336..4642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_057849.4 Gag-Pol [Human immunodeficiency virus 1]

      See identical proteins and their annotated locations for NP_057849.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P04585
      Conserved Domains (12) summary
      smart00343
      Location:391406
      ZnF_C2HC; zinc finger
      cd01645
      Location:605821
      RT_Rtv; RT_Rtv: Reverse transcriptases (RTs) from retroviruses (Rtvs). RTs catalyze the conversion of single-stranded RNA into double-stranded viral DNA for integration into host chromosomes. Proteins in this subfamily contain long terminal repeats (LTRs) and ...
      pfam00540
      Location:2132
      Gag_p17; gag gene protein p17 (matrix protein)
      pfam00075
      Location:10241144
      RNase_H; RNase H
      pfam00077
      Location:495586
      RVP; Retroviral aspartyl protease
      pfam00078
      Location:650821
      RVT_1; Reverse transcriptase (RNA-dependent DNA polymerase)
      pfam00552
      Location:13681415
      IN_DBD_C; Integrase DNA binding domain
      pfam00607
      Location:149363
      Gag_p24; gag gene protein p24 (core nucleocapsid protein)
      pfam00665
      Location:12051306
      rve; Integrase core domain
      pfam02022
      Location:11551192
      Integrase_Zn; Integrase Zinc binding domain
      pfam06815
      Location:9051006
      RVT_connect; Reverse transcriptase connection domain
      pfam06817
      Location:830883
      RVT_thumb; Reverse transcriptase thumb domain
    2. NP_787043.1 Gag-Pol Transframe peptide

    3. NP_705926.1 aspartic peptidase

      Conserved Domains (1) summary
      pfam00077
      Location:798
      RVP; Retroviral aspartyl protease
    4. NP_705927.1 p66 subunit

      Conserved Domains (5) summary
      cd01645
      Location:18234
      RT_Rtv; RT_Rtv: Reverse transcriptases (RTs) from retroviruses (Rtvs). RTs catalyze the conversion of single-stranded RNA into double-stranded viral DNA for integration into host chromosomes. Proteins in this subfamily contain long terminal repeats (LTRs) and ...
      pfam00075
      Location:437557
      RNase_H; RNase H
      pfam00078
      Location:63234
      RVT_1; Reverse transcriptase (RNA-dependent DNA polymerase)
      pfam06815
      Location:318419
      RVT_connect; Reverse transcriptase connection domain
      pfam06817
      Location:243296
      RVT_thumb; Reverse transcriptase thumb domain
    5. NP_705928.1 integrase

      Conserved Domains (3) summary
      pfam00552
      Location:221268
      IN_DBD_C; Integrase DNA binding domain
      pfam00665
      Location:58159
      rve; Integrase core domain
      pfam02022
      Location:845
      Integrase_Zn; Integrase Zinc binding domain
    6. NP_789739.1 reverse transcriptase p51 subunit

      Conserved Domains (4) summary
      pfam00078
      Location:63234
      RVT_1; Reverse transcriptase (RNA-dependent DNA polymerase)
      pfam06815
      Location:318419
      RVT_connect; Reverse transcriptase connection domain
      pfam06817
      Location:243296
      RVT_thumb; Reverse transcriptase thumb domain
      cl02808
      Location:18234
      RT_like; RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons, ...
    7. NP_789740.1 Pol

      Conserved Domains (9) summary
      cd01645
      Location:165381
      RT_Rtv; RT_Rtv: Reverse transcriptases (RTs) from retroviruses (Rtvs). RTs catalyze the conversion of single-stranded RNA into double-stranded viral DNA for integration into host chromosomes. Proteins in this subfamily contain long terminal repeats (LTRs) and ...
      pfam00075
      Location:584704
      RNase_H; RNase H
      pfam00077
      Location:55146
      RVP; Retroviral aspartyl protease
      pfam00078
      Location:210381
      RVT_1; Reverse transcriptase (RNA-dependent DNA polymerase)
      pfam00552
      Location:928975
      IN_DBD_C; Integrase DNA binding domain
      pfam00665
      Location:765866
      rve; Integrase core domain
      pfam02022
      Location:715752
      Integrase_Zn; Integrase Zinc binding domain
      pfam06815
      Location:465566
      RVT_connect; Reverse transcriptase connection domain
      pfam06817
      Location:390443
      RVT_thumb; Reverse transcriptase thumb domain
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