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    LTK leukocyte receptor tyrosine kinase [ Homo sapiens (human) ]

    Gene ID: 4058, updated on 5-Nov-2017
    Official Symbol
    LTKprovided by HGNC
    Official Full Name
    leukocyte receptor tyrosine kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:6721
    See related
    Ensembl:ENSG00000062524 MIM:151520; Vega:OTTHUMG00000130339
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TYK1
    Summary
    The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
    Expression
    Broad expression in duodenum (RPKM 6.4), lung (RPKM 6.1) and 15 other tissues See more
    Orthologs
    Location:
    15q15.1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 15 NC_000015.10 (41503639..41513887, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (41795840..41806085, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RTF1 homolog, Paf1/RNA polymerase II complex component Neighboring gene uncharacterized LOC105370790 Neighboring gene inositol-trisphosphate 3-kinase A Neighboring gene RNA polymerase II associated protein 1 Neighboring gene elongin C pseudogene 2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    leukocyte tyrosine kinase receptor
    Names
    protein tyrosine kinase 1
    NP_001129157.1
    NP_002335.2
    NP_996844.1
    XP_011519858.1
    XP_011519859.1
    XP_016877670.1
    XP_016877671.1
    XP_016877672.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135685.1NP_001129157.1  leukocyte tyrosine kinase receptor isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two internal coding exons and uses an alternate splice site in the central coding region, compared to variant 1. The resulting isoform (3) is missing two internal segments and has a short segment in an alternate reading frame but with the same N- and C-termini, compared to isoform 1.
      Source sequence(s)
      AC016134, AK296892, CA394397
      Consensus CDS
      CCDS45237.1
      UniProtKB/Swiss-Prot
      P29376
      Related
      ENSP00000392196.2, OTTHUMP00000248925, ENST00000453182.2, OTTHUMT00000419601
      Conserved Domains (2) summary
      pfam07714
      Location:415647
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:414649
      PKc_like; Protein Kinases, catalytic domain
    2. NM_002344.5NP_002335.2  leukocyte tyrosine kinase receptor isoform 1 precursor

      See identical proteins and their annotated locations for NP_002335.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK296892, CA394397, D16105
      Consensus CDS
      CCDS10077.1
      UniProtKB/Swiss-Prot
      P29376
      Related
      ENSP00000263800.6, OTTHUMP00000160858, ENST00000263800.10, OTTHUMT00000252690
      Conserved Domains (2) summary
      cd05036
      Location:503779
      PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase
      pfam07714
      Location:510777
      Pkinase_Tyr; Protein tyrosine kinase
    3. NM_206961.3NP_996844.1  leukocyte tyrosine kinase receptor isoform 2 precursor

      See identical proteins and their annotated locations for NP_996844.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is lacking one of the internal coding exons compared to variant 1. This results in an isoform (2) that is missing a 61 aa segment compared to isoform 1.
      Source sequence(s)
      AC016134, AK296892, CA394397, X60702
      Consensus CDS
      CCDS10078.1
      UniProtKB/Swiss-Prot
      P29376
      Related
      ENSP00000347293.5, OTTHUMP00000160859, ENST00000355166.9, OTTHUMT00000252691
      Conserved Domains (2) summary
      cd05036
      Location:442718
      PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase
      pfam07714
      Location:449716
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p7 Primary Assembly

      Range
      41503639..41513887 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017022181.1XP_016877670.1  leukocyte tyrosine kinase receptor isoform X1

    2. XM_011521557.2XP_011519859.1  leukocyte tyrosine kinase receptor isoform X4

      Conserved Domains (2) summary
      cd05036
      Location:463739
      PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase
      pfam07714
      Location:470737
      Pkinase_Tyr; Protein tyrosine kinase
    3. XM_011521556.2XP_011519858.1  leukocyte tyrosine kinase receptor isoform X2

      Conserved Domains (2) summary
      cd05036
      Location:519795
      PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase
      pfam07714
      Location:526793
      Pkinase_Tyr; Protein tyrosine kinase
    4. XM_017022182.1XP_016877671.1  leukocyte tyrosine kinase receptor isoform X3

    5. XM_017022183.1XP_016877672.1  leukocyte tyrosine kinase receptor isoform X5

    RNA

    1. XR_001751277.1 RNA Sequence

    2. XR_001751279.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018926.2 Alternate CHM1_1.1

      Range
      41914406..41924652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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