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    Cnr1 cannabinoid receptor 1 (brain) [ Mus musculus (house mouse) ]

    Gene ID: 12801, updated on 20-Jun-2017
    Official Symbol
    Cnr1provided by MGI
    Official Full Name
    cannabinoid receptor 1 (brain)provided by MGI
    Primary source
    MGI:MGI:104615
    See related
    Ensembl:ENSMUSG00000044288 Vega:OTTMUSG00000008304
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CB1; CB-R; CB1R
    Orthologs
    Location:
    4 A5; 4 16.28 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (33923844..33948831)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (34011607..34035806)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 33059 Neighboring gene predicted gene, 33008 Neighboring gene predicted gene, 33105 Neighboring gene sperm acrosome associated 1 Neighboring gene U6 snRNA-associated Sm-like protein LSm3 pseudogene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G-protein coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    cannabinoid receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cannabinoid receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    drug binding ISO
    Inferred from Sequence Orthology
    more info
     
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    adenylate cyclase-modulating G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    aging ISO
    Inferred from Sequence Orthology
    more info
     
    axonal fasciculation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cannabinoid signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucose homeostasis IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    learning or memory ISO
    Inferred from Sequence Orthology
    more info
     
    memory ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of action potential ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of dopamine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mast cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of nitric-oxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of acute inflammatory response to antigenic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fever generation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of feeding behavior ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of penile erection ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synaptic transmission, GABAergic ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    response to cocaine ISO
    Inferred from Sequence Orthology
    more info
     
    response to ethanol ISO
    Inferred from Sequence Orthology
    more info
     
    response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    response to morphine ISO
    Inferred from Sequence Orthology
    more info
     
    response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    cannabinoid receptor 1
    Names
    brain-type cannabinoid receptor
    striatal cannabinoid receptor type 1 protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007726.3NP_031752.1  cannabinoid receptor 1

      See identical proteins and their annotated locations for NP_031752.1

      Status: VALIDATED

      Source sequence(s)
      BC070447, BX005292
      Consensus CDS
      CCDS18025.1
      UniProtKB/Swiss-Prot
      P47746
      Related
      ENSMUSP00000055797.6, OTTMUSP00000008684, ENSMUST00000057188.6, OTTMUST00000018900
      Conserved Domains (2) summary
      pfam00001
      Location:134398
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:135413
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      33923844..33948831
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537594.2XP_006537657.1  cannabinoid receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_006537657.1

      UniProtKB/Swiss-Prot
      P47746
      Conserved Domains (2) summary
      pfam00001
      Location:134398
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:135413
      7tm_4; Olfactory receptor
    2. XM_006537595.2XP_006537658.1  cannabinoid receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_006537658.1

      UniProtKB/Swiss-Prot
      P47746
      Conserved Domains (2) summary
      pfam00001
      Location:134398
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:135413
      7tm_4; Olfactory receptor
    3. XM_017319939.1XP_017175428.1  cannabinoid receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      P47746
      Conserved Domains (2) summary
      pfam00001
      Location:134398
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:135413
      7tm_4; Olfactory receptor
    4. XM_006537592.3XP_006537655.1  cannabinoid receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_006537655.1

      UniProtKB/Swiss-Prot
      P47746
      Related
      ENSMUSP00000081787.2, OTTMUSP00000008685, ENSMUST00000084736.2, OTTMUST00000018902
      Conserved Domains (2) summary
      pfam00001
      Location:134398
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:135413
      7tm_4; Olfactory receptor
    5. XM_006537591.2XP_006537654.1  cannabinoid receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_006537654.1

      UniProtKB/Swiss-Prot
      P47746
      Conserved Domains (2) summary
      pfam00001
      Location:134398
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:135413
      7tm_4; Olfactory receptor
    6. XM_006537593.3XP_006537656.1  cannabinoid receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_006537656.1

      UniProtKB/Swiss-Prot
      P47746
      Conserved Domains (2) summary
      pfam00001
      Location:134398
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:135413
      7tm_4; Olfactory receptor
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