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    IL33 interleukin 33 [ Homo sapiens (human) ]

    Gene ID: 90865, updated on 10-Dec-2017
    Official Symbol
    IL33provided by HGNC
    Official Full Name
    interleukin 33provided by HGNC
    Primary source
    HGNC:HGNC:16028
    See related
    Ensembl:ENSG00000137033 MIM:608678; Vega:OTTHUMG00000019516
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26
    Summary
    The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in urinary bladder (RPKM 34.7), lung (RPKM 27.3) and 23 other tissues See more
    Orthologs
    Location:
    9p24.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 9 NC_000009.12 (6214591..6257983)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (6215149..6257983)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene RAN binding protein 6 Neighboring gene general transcription factor IIIA pseudogene 1 Neighboring gene uncharacterized LOC107987046 Neighboring gene selenoprotein T pseudogene 1 Neighboring gene tumor protein D52 like 3

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
    NHGRI GWA Catalog
    A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations.
    NHGRI GWA Catalog
    A large-scale, consortium-based genomewide association study of asthma.
    NHGRI GWA Catalog
    Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
    NHGRI GWA Catalog
    Genome-wide association study link novel loci to endometriosis.
    NHGRI GWA Catalog
    Genome-wide association study of periodontal pathogen colonization.
    NHGRI GWA Catalog
    Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    In vitro infection with HIV-1 subtype B upregulates IL-33 expression in primary human astrocytes and SKNMC cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Cytosolic DNA-sensing pathway, organism-specific biosystem (from KEGG)
      Cytosolic DNA-sensing pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
    • Cytosolic DNA-sensing pathway, conserved biosystem (from KEGG)
      Cytosolic DNA-sensing pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
    • Deubiquitination, organism-specific biosystem (from REACTOME)
      Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
    • Development and heterogeneity of the ILC family, organism-specific biosystem (from WikiPathways)
      Development and heterogeneity of the ILC family, organism-specific biosystemDevelopment and heterogeneity of the ILC family. ILCs develop from distinct progenitors in the fetal liver or bone marrow and then develop into mature ILCs in the periphery. Different transcription f...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • Ub-specific processing proteases, organism-specific biosystem (from REACTOME)
      Ub-specific processing proteases, organism-specific biosystemUb-specific processing proteases (USPs) are the largest of the DUB families with more than 50 members in humans. The USP catalytic domain varies considerably in size and consists of six conserved mo...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • DKFZp586H0523

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    microglial cell activation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    microglial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of T-helper 1 type immune response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of immunoglobulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interferon-gamma production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of leukocyte migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of chemokine secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of immunoglobulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of interleukin-13 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-4 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-5 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of macrophage activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of type 2 immune response IEA
    Inferred from Electronic Annotation
    more info
     
    protein deubiquitination TAS
    Traceable Author Statement
    more info
     
    regulation of receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    type 2 immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    transport vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    interleukin-33
    Names
    DVS27-related protein
    interleukin-1 family member 11
    nuclear factor for high endothelial venules
    nuclear factor from high endothelial venules

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047209.1 RefSeqGene

      Range
      5001..47835
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001199640.1NP_001186569.1  interleukin-33 isoform b

      See identical proteins and their annotated locations for NP_001186569.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b, also known as 2) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AB024518, AI610794, AK303943, BC047085, DB477860
      Consensus CDS
      CCDS56563.1
      UniProtKB/Swiss-Prot
      O95760
      Related
      ENSP00000414238.2, ENST00000456383.3
      Conserved Domains (1) summary
      pfam15095
      Location:5226
      IL33; Interleukin 33
    2. NM_001199641.1NP_001186570.1  interleukin-33 isoform c

      See identical proteins and their annotated locations for NP_001186570.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (c, also known as 3) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AB024518, AI610794, AK295908, BC047085, DB477860
      Consensus CDS
      CCDS56564.1
      UniProtKB/Swiss-Prot
      O95760
      Related
      ENSP00000394039.2, ENST00000417746.6
      Conserved Domains (1) summary
      pfam15095
      Location:31142
      IL33; Interleukin 33
    3. NM_001314044.1NP_001300973.1  interleukin-33 isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 4, and 5 all encode the same isoform (a).
      Source sequence(s)
      AB024518, AI610794, DA713547
      Consensus CDS
      CCDS6468.1
      UniProtKB/Swiss-Prot
      O95760
      Related
      ENSP00000370842.3, OTTHUMP00000021041, ENST00000381434.7, OTTHUMT00000051655
      Conserved Domains (1) summary
      pfam15095
      Location:5268
      IL33; Interleukin 33
    4. NM_001314045.1NP_001300974.1  interleukin-33 isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 4, and 5 all encode the same isoform (a).
      Source sequence(s)
      AB024518, AI610794, DA439244
      Consensus CDS
      CCDS6468.1
      UniProtKB/Swiss-Prot
      O95760
      Conserved Domains (1) summary
      pfam15095
      Location:5268
      IL33; Interleukin 33
    5. NM_001314046.1NP_001300975.1  interleukin-33 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is shorter compared to isoform a. Variants 6 and 7 both encode the same isoform (d).
      Source sequence(s)
      AB024518, AI610794, DB199599, DB266668
      UniProtKB/Swiss-Prot
      O95760
      Conserved Domains (1) summary
      pfam15095
      Location:5262
      IL33; Interleukin 33
    6. NM_001314047.1NP_001300976.1  interleukin-33 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is shorter compared to isoform a. Variants 6 and 7 both encode the same isoform (d).
      Source sequence(s)
      AB024518, AI610794, DA713547, DA719342
      UniProtKB/Swiss-Prot
      O95760
      Conserved Domains (1) summary
      pfam15095
      Location:5262
      IL33; Interleukin 33
    7. NM_001314048.1NP_001300977.1  interleukin-33 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (e) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AB024518, AI610794, DB199599, HQ641439
      Consensus CDS
      CCDS83341.1
      UniProtKB/Swiss-Prot
      O95760
      Related
      ENSP00000478858.1, ENST00000611532.4
      Conserved Domains (1) summary
      pfam15095
      Location:5226
      IL33; Interleukin 33
    8. NM_001353802.1NP_001340731.1  interleukin-33 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks alternate exons in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The promoter and 5' terminal exon sequence is from an endogenous retroviral LTR (PMID: 28715472). The resulting isoform (f),has a distinct N-terminus and is shorter than isoform 1. The encoded protein is expressed in a subset of colon cancer cells.
      Source sequence(s)
      AL353741
      Conserved Domains (1) summary
      pfam15095
      Location:1227
      IL33; Interleukin 33
    9. NM_033439.3NP_254274.1  interleukin-33 isoform a precursor

      See identical proteins and their annotated locations for NP_254274.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a, also known as 1). Variants 1, 4, and 5 all encode the same isoform (a).
      Source sequence(s)
      AB024518, AI610794, BC047085, DB477860
      Consensus CDS
      CCDS6468.1
      UniProtKB/Swiss-Prot
      O95760
      Conserved Domains (1) summary
      pfam15095
      Location:5268
      IL33; Interleukin 33

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p7 Primary Assembly

      Range
      6214591..6257983
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017015285.1XP_016870774.1  interleukin-33 isoform X1

      Conserved Domains (1) summary
      pfam15095
      Location:5262
      IL33; Interleukin 33
    2. XM_011518061.2XP_011516363.1  interleukin-33 isoform X2

      Conserved Domains (1) summary
      pfam15095
      Location:1227
      IL33; Interleukin 33

    Alternate CHM1_1.1

    Genomic

    1. NC_018920.2 Alternate CHM1_1.1

      Range
      6215757..6258768
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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