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    LATS2 large tumor suppressor kinase 2 [ Homo sapiens (human) ]

    Gene ID: 26524, updated on 3-Sep-2017
    Official Symbol
    LATS2provided by HGNC
    Official Full Name
    large tumor suppressor kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:6515
    See related
    Ensembl:ENSG00000150457 MIM:604861; Vega:OTTHUMG00000016531
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KPM
    Summary
    This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    13q12.11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 13 NC_000013.11 (20973036..21061583, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (21547175..21635722, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A pseudogene 27 Neighboring gene ribosomal protein SA pseudogene 54 Neighboring gene RNA, U4 small nuclear 9, pseudogene Neighboring gene uncharacterized LOC105370104 Neighboring gene ribosomal protein S12 pseudogene 23

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Coregulation of Androgen receptor activity, organism-specific biosystem (from Pathway Interaction Database)
      Coregulation of Androgen receptor activity, organism-specific biosystem
      Coregulation of Androgen receptor activity
    • Hippo signaling, organism-specific biosystem (from KEGG)
      Hippo signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
    • Hippo signaling, conserved biosystem (from KEGG)
      Hippo signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
    • Hippo signaling pathway, organism-specific biosystem (from KEGG)
      Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Hippo signaling pathway, conserved biosystem (from KEGG)
      Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Hippo signaling pathway -multiple species, organism-specific biosystem (from KEGG)
      Hippo signaling pathway -multiple species, organism-specific biosystemHippo signaling pathways control diverse aspects of cell proliferation, survival, and morphogenesis in eukaryotes. The core organization of these networks is conserved over a billion years of evoluti...
    • Hippo signaling pathway -multiple species, conserved biosystem (from KEGG)
      Hippo signaling pathway -multiple species, conserved biosystemHippo signaling pathways control diverse aspects of cell proliferation, survival, and morphogenesis in eukaryotes. The core organization of these networks is conserved over a billion years of evoluti...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Hippo, organism-specific biosystem (from REACTOME)
      Signaling by Hippo, organism-specific biosystemHuman Hippo signaling is a network of reactions that regulates cell proliferation and apoptosis, centered on a three-step kinase cascade. The cascade was discovered by analysis of Drosophila mutation...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ13161

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    hippo signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hippo signaling TAS
    Traceable Author Statement
    more info
     
    hormone-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of organ growth IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    microtubule organizing center IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    serine/threonine-protein kinase LATS2
    Names
    LATS (large tumor suppressor, Drosophila) homolog 2
    LATS, large tumor suppressor, homolog 2
    kinase phosphorylated during mitosis protein
    large tumor suppressor homolog 2
    serine/threonine kinase KPM
    serine/threonine-protein kinase kpm
    warts-like kinase
    NP_055387.2
    XP_005266399.1
    XP_011533344.1
    XP_016876030.1
    XP_016876031.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014572.2NP_055387.2  serine/threonine-protein kinase LATS2

      See identical proteins and their annotated locations for NP_055387.2

      Status: REVIEWED

      Source sequence(s)
      AF207547, AL356285, BQ774580, DB452765
      Consensus CDS
      CCDS9294.1
      UniProtKB/Swiss-Prot
      Q9NRM7
      UniProtKB/TrEMBL
      A0A024RDM3
      Related
      ENSP00000372035.4, OTTHUMP00000018106, ENST00000382592.4, OTTHUMT00000044102
      Conserved Domains (3) summary
      cd05626
      Location:6661046
      STKc_LATS2; Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2
      smart00220
      Location:668973
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14398
      Location:101141
      UBA_LATS2; UBA domain found in vertebrate serine/threonine-protein kinase LATS2

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p7 Primary Assembly

      Range
      20973036..21061583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020542.1XP_016876031.1  serine/threonine-protein kinase LATS2 isoform X4

    2. XM_005266342.1XP_005266399.1  serine/threonine-protein kinase LATS2 isoform X1

      See identical proteins and their annotated locations for XP_005266399.1

      UniProtKB/Swiss-Prot
      Q9NRM7
      UniProtKB/TrEMBL
      A0A024RDM3
      Conserved Domains (3) summary
      cd05626
      Location:6661046
      STKc_LATS2; Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2
      smart00220
      Location:668973
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14398
      Location:101141
      UBA_LATS2; UBA domain found in vertebrate serine/threonine-protein kinase LATS2
    3. XM_017020541.1XP_016876030.1  serine/threonine-protein kinase LATS2 isoform X3

    4. XM_011535042.2XP_011533344.1  serine/threonine-protein kinase LATS2 isoform X2

      Conserved Domains (3) summary
      cd05626
      Location:579959
      STKc_LATS2; Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2
      smart00220
      Location:581886
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21463
      Location:2454
      UBA_like_SF; UBA domain-like superfamily

    Alternate CHM1_1.1

    Genomic

    1. NC_018924.2 Alternate CHM1_1.1

      Range
      21515524..21603910 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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