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    OXT oxytocin/neurophysin I prepropeptide [ Homo sapiens (human) ]

    Gene ID: 5020, updated on 6-Dec-2016
    Official Symbol
    OXTprovided by HGNC
    Official Full Name
    oxytocin/neurophysin I prepropeptideprovided by HGNC
    Primary source
    HGNC:HGNC:8528
    See related
    Ensembl:ENSG00000101405 MIM:167050; Vega:OTTHUMG00000031724
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OT; OT-NPI; OXT-NPI
    Summary
    This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. [provided by RefSeq, Dec 2013]
    Orthologs
    Location:
    20p13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 20 NC_000020.11 (3068871..3072517)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3052266..3053163)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene gonadotropin releasing hormone 2 Neighboring gene mitochondrial ribosomal protein S26 Neighboring gene uncharacterized LOC101929098 Neighboring gene arginine vasopressin Neighboring gene RNA, 7SL, cytoplasmic 555, pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
      Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
    • Oxytocin signaling pathway, organism-specific biosystem (from KEGG)
      Oxytocin signaling pathway, organism-specific biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
    • Oxytocin signaling pathway, conserved biosystem (from KEGG)
      Oxytocin signaling pathway, conserved biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
    • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
      Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Vasopressin-like receptors, organism-specific biosystem (from REACTOME)
      Vasopressin-like receptors, organism-specific biosystemThe vasopressins are peptide hormones consisting of nine amino acids (nonapeptides). They include arginine vasopressin (AVP; anti-diuretic hormone, ADH) and oxytocin. They are synthesized in the hypo...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC126890, MGC126892

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    neurohypophyseal hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxytocin receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    drinking behavior IEA
    Inferred from Electronic Annotation
    more info
     
    eating behavior IEA
    Inferred from Electronic Annotation
    more info
     
    female pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    grooming behavior IEA
    Inferred from Electronic Annotation
    more info
     
    heart development IEA
    Inferred from Electronic Annotation
    more info
     
    hyperosmotic salinity response IEA
    Inferred from Electronic Annotation
    more info
     
    male mating behavior IEA
    Inferred from Electronic Annotation
    more info
     
    maternal aggressive behavior IEA
    Inferred from Electronic Annotation
    more info
     
    maternal behavior IEA
    Inferred from Electronic Annotation
    more info
     
    memory IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of gastric acid secretion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of urine volume IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of female receptivity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of hindgut contraction IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of norepinephrine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ossification IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of penile erection IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of prostaglandin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of renal sodium excretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of synapse assembly IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of uterine smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of heart rate IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    response to activity IEA
    Inferred from Electronic Annotation
    more info
     
    response to amphetamine IEA
    Inferred from Electronic Annotation
    more info
     
    response to cAMP IEA
    Inferred from Electronic Annotation
    more info
     
    response to cocaine IEA
    Inferred from Electronic Annotation
    more info
     
    response to electrical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    response to ether IEA
    Inferred from Electronic Annotation
    more info
     
    response to food IEA
    Inferred from Electronic Annotation
    more info
     
    response to glucocorticoid IEA
    Inferred from Electronic Annotation
    more info
     
    response to peptide hormone IEA
    Inferred from Electronic Annotation
    more info
     
    response to progesterone IEA
    Inferred from Electronic Annotation
    more info
     
    response to prostaglandin E IEA
    Inferred from Electronic Annotation
    more info
     
    response to retinoic acid IEA
    Inferred from Electronic Annotation
    more info
     
    response to sucrose IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    sleep IEA
    Inferred from Electronic Annotation
    more info
     
    social behavior IEA
    Inferred from Electronic Annotation
    more info
     
    sperm ejaculation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    secretory granule IEA
    Inferred from Electronic Annotation
    more info
     
    terminal bouton IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    oxytocin-neurophysin 1
    Names
    neurophysin I
    oxytocin, prepro- (neurophysin I)
    oxytocin, prepropeptide
    oxytocin-neurophysin I, preproprotein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000915.3NP_000906.1  oxytocin-neurophysin 1 preproprotein

      See identical proteins and their annotated locations for NP_000906.1

      Status: REVIEWED

      Source sequence(s)
      AI185553, BC069144
      Consensus CDS
      CCDS13044.1
      UniProtKB/Swiss-Prot
      P01178
      UniProtKB/TrEMBL
      X5D7M6
      Related
      ENSP00000217386, OTTHUMP00000030079, ENST00000217386, OTTHUMT00000077698
      Conserved Domains (1) summary
      pfam00184
      Location:39116
      Hormone_5; Neurohypophysial hormones, C-terminal Domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p7 Primary Assembly

      Range
      3068871..3072517
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011529238.1XP_011527540.1  

      See identical proteins and their annotated locations for XP_011527540.1

      UniProtKB/Swiss-Prot
      P01178
      UniProtKB/TrEMBL
      X5D7M6
      Conserved Domains (1) summary
      pfam00184
      Location:39116
      Hormone_5; Neurohypophysial hormones, C-terminal Domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018931.2 Alternate CHM1_1.1

      Range
      3046806..3047704
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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