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    HA haemagglutinin [ Influenza A virus (A/Puerto Rico/8/1934(H1N1)) ]

    Gene ID: 956529, updated on 22-Apr-2017
    Gene symbol
    HA
    Gene description
    haemagglutinin
    Locus tag
    FLUAVs4gp1
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Influenza A virus (A/Puerto Rico/8/1934(H1N1)) (strain: A/Puerto Rico/8/1934, serotype: H1N1, old-name: Influenza A virus (A/Puerto Rico/8/34(H1N1)))
    Lineage
    Viruses; ssRNA viruses; ssRNA negative-strand viruses; Orthomyxoviridae; Influenzavirus A
    Location:
    segment: 4
    Sequence:
    NC_002017.1 (33..1733)

    NC_002017.1Genomic Context describing neighboring genes

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Assembly of Viral Components at the Budding Site, organism-specific biosystem (from REACTOME)
      Assembly of Viral Components at the Budding Site, organism-specific biosystemFollowing synthesis on membrane-bound ribosomes, the three viral integral membrane proteins, HA (hemagglutinin), NA (neuraminidase) and M2 (ion channel) enter the host endoplasmic reticulum (ER) wher...
    • Budding, organism-specific biosystem (from REACTOME)
      Budding, organism-specific biosystemThe process by which influenza virus particles bud from an infected cell is not very well understood. Accumulation of M1 at the inner leaflet of the plasma membrane is thought to be the trigger for ...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Entry of Influenza Virion into Host Cell via Endocytosis, organism-specific biosystem (from REACTOME)
      Entry of Influenza Virion into Host Cell via Endocytosis, organism-specific biosystemVirus particles bound to the cell surface can be internalized by four mechanisms. Most internalization appears to be mediated by clathrin-coated pits, but internalization via caveolae, macropinocytos...
    • Fusion and Uncoating of the Influenza Virion, organism-specific biosystem (from REACTOME)
      Fusion and Uncoating of the Influenza Virion, organism-specific biosystemUncoating of viral particles takes place in the host cell endosome. Acidification of the endosome promotes fusion of the viral and endosomal membranes, causing a structural change in the viral hemagg...
    • Fusion of the Influenza Virion to the Host Cell Endosome, organism-specific biosystem (from REACTOME)
      Fusion of the Influenza Virion to the Host Cell Endosome, organism-specific biosystemAfter the virus binds to the target cell surface and is endocytosed, the low pH of the endosome causes the viral HA (hemagglutinin) to undergo a structural change which frees the fusion peptide of it...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
    • Infectious disease, organism-specific biosystem (from REACTOME)
      Infectious disease, organism-specific biosystem
      Infectious disease
    • Influenza A virus infection, organism-specific biosystem (from WikiPathways)
      Influenza A virus infection, organism-specific biosystem
      Influenza A virus infection
    • Influenza Infection, organism-specific biosystem (from REACTOME)
      Influenza Infection, organism-specific biosystemFor centuries influenza epidemics have plagued man, and influenza was probably the disease described by Hippocrates in 412 BC. Today it remains a major cause of morbidity and mortality worldwide with...
    • Influenza Life Cycle, organism-specific biosystem (from REACTOME)
      Influenza Life Cycle, organism-specific biosystemThe virus particle initially associates with a human host cell by binding to sialic acid-containing receptors on the host cell surface. The bound virus is endocytosed by one of four distinct mechanis...
    • Influenza Viral RNA Transcription and Replication, organism-specific biosystem (from REACTOME)
      Influenza Viral RNA Transcription and Replication, organism-specific biosystemIn the host cell nucleus, the viral negative-strand RNA (vRNA) serves as a template for the synthesis both of capped, polyadenylated viral messenger RNA and of full-length positive-strand RNA or comp...
    • Packaging of Eight RNA Segments, organism-specific biosystem (from REACTOME)
      Packaging of Eight RNA Segments, organism-specific biosystemFor a budding influenza virus to be fully infectious is it essential that it contains a full complement of the eight vRNA segments. Two different models have been proposed for packaging of the vRNPs ...
    • Release, organism-specific biosystem (from REACTOME)
      Release, organism-specific biosystemOnce the viral envelope has separated from the cell membrane Influenza virus particles are actively released to complete the budding process. HA (hemagglutinin) anchors the virus to the cell by bindi...
    • Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus, organism-specific biosystem (from REACTOME)
      Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus, organism-specific biosystemProcessed viral proteins are transported from the endoplasmic reticulum to the Golgi apparatus.
    • Uncoating of the Influenza Virion, organism-specific biosystem (from REACTOME)
      Uncoating of the Influenza Virion, organism-specific biosystemThe precise timing and location of uncoating (early vs. late endosomes) depends on the pH-mediated transition of the specific viral hemagglutinin (HA) molecule involved. The uncoating of influenza vi...
    • Viral mRNA Translation, organism-specific biosystem (from REACTOME)
      Viral mRNA Translation, organism-specific biosystemSpliced and unspliced viral mRNA in the cytoplasm are translated by host cell ribosomal translation machinery (reviewed in Kash, 2006). At least ten viral proteins are synthesized: HA, NA, PB1, PB2...
    • Virus Assembly and Release, organism-specific biosystem (from REACTOME)
      Virus Assembly and Release, organism-specific biosystemInfluenza viruses assemble and bud from the apical plasma membrane of polarized cells e.g. lung epithelial cells of the infected host. This asymmetrical process (i.e. apical [Influenza virus] or baso...

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002017.1 Reference assembly

      Range
      33..1733
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_040980.1 haemagglutinin [Influenza A virus (A/Puerto Rico/8/1934(H1N1))]

      See identical proteins and their annotated locations for NP_040980.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P03452
      Conserved Domains (1) summary
      pfam00509
      Location:20566
      Hemagglutinin; Haemagglutinin
    2. YP_163735.1 HA1

      Conserved Domains (1) summary
      pfam00509
      Location:3327
      Hemagglutinin; Haemagglutinin
    3. YP_163736.1 HA2

      Conserved Domains (1) summary
      pfam00509
      Location:1222
      Hemagglutinin; Haemagglutinin
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