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    HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 [ Homo sapiens (human) ]

    Gene ID: 8924, updated on 3-Sep-2017
    Official Symbol
    HERC2provided by HGNC
    Official Full Name
    HECT and RLD domain containing E3 ubiquitin protein ligase 2provided by HGNC
    Primary source
    HGNC:HGNC:4868
    See related
    Ensembl:ENSG00000128731 MIM:605837; Vega:OTTHUMG00000129251
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    jdf2; p528; MRT38; SHEP1; D15F37S1
    Summary
    This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16. [provided by RefSeq, Mar 2012]
    Orthologs
    Location:
    15q13.1
    Exon count:
    98
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 15 NC_000015.10 (28111037..28322173, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (28356183..28567313, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid type A receptor gamma3 subunit Neighboring gene uncharacterized LOC105370741 Neighboring gene OCA2 melanosomal transmembrane protein Neighboring gene ribosomal protein L5 pseudogene 32 Neighboring gene uncharacterized LOC101060587 Neighboring gene ribosomal protein L41 pseudogene 2 Neighboring gene hect domain and RLD 2 pseudogene 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Mental retardation, autosomal recessive 38
    MedGen: C3809753 OMIM: 615516 GeneReviews: Not available
    Compare labs
    Prader-Willi syndrome
    MedGen: C0032897 OMIM: 176270 GeneReviews: Prader-Willi Syndrome
    Compare labs
    Skin/hair/eye pigmentation, variation in, 1
    MedGen: C1856895 OMIM: 227220 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.
    NHGRI GWA Catalog
    Digital quantification of human eye color highlights genetic association of three new loci.
    NHGRI GWA Catalog
    Genetic determinants of hair, eye and skin pigmentation in Europeans.
    NHGRI GWA Catalog
    Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.
    NHGRI GWA Catalog
    Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.
    NHGRI GWA Catalog
    Genome-wide association studies of quantitatively measured skin, hair, and eye pigmentation in four European populations.
    NHGRI GWA Catalog
    The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.
    NHGRI GWA Catalog
    Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene.
    NHGRI GWA Catalog
    Web-based, participant-driven studies yield novel genetic associations for common traits.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with hect domain and RLD 2 (HERC2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
      Cell Cycle Checkpoints, organism-specific biosystemA hallmark of the human cell cycle in normal somatic cells is its precision. This remarkable fidelity is achieved by a number of signal transduction pathways, known as checkpoints, which monitor cell...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • DNA Double Strand Break Response, organism-specific biosystem (from REACTOME)
      DNA Double Strand Break Response, organism-specific biosystemDNA double strand break (DSB) response involves sensing of DNA DSBs by the MRN complex which triggers ATM activation. ATM phosphorylates a number of proteins involved in DNA damage checkpoint signali...
    • DNA Double-Strand Break Repair, organism-specific biosystem (from REACTOME)
      DNA Double-Strand Break Repair, organism-specific biosystemNumerous types of DNA damage can occur within a cell due to the endogenous production of oxygen free radicals, normal alkylation reactions, or exposure to exogenous radiations and chemicals. Double-s...
    • DNA Repair, organism-specific biosystem (from REACTOME)
      DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. Living organisms are constantly exposed to harmful metabolic by-products, enviro...
    • G2/M Checkpoints, organism-specific biosystem (from REACTOME)
      G2/M Checkpoints, organism-specific biosystemG2/M checkpoints include the checks for damaged DNA, unreplicated DNA, and checks that ensure that the genome is replicated once and only once per cell cycle. If cells pass these checkpoints, they f...
    • G2/M DNA damage checkpoint, organism-specific biosystem (from REACTOME)
      G2/M DNA damage checkpoint, organism-specific biosystemThroughout the cell cycle, the genome is constantly monitored for damage, resulting either from errors of replication, by-products of metabolism or through extrinsic sources such as ultra-violet or i...
    • HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA), organism-specific biosystem (from REACTOME)
      HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA), organism-specific biosystemHomology directed repair (HDR) of replication-independent DNA double strand breaks (DSBs) via homologous recombination repair (HRR) or single strand annealing (SSA) requires the activation of ATM fol...
    • Homology Directed Repair, organism-specific biosystem (from REACTOME)
      Homology Directed Repair, organism-specific biosystemHomology directed repair (HDR) of DNA double strand breaks (DSBs) requires resection of DNA DSB ends. Resection creates 3'-ssDNA overhangs which then anneal with a homologous DNA sequence. This homol...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Nonhomologous End-Joining (NHEJ), organism-specific biosystem (from REACTOME)
      Nonhomologous End-Joining (NHEJ), organism-specific biosystemThe nonhomologous end joining (NHEJ) pathway is initiated in response to the formation of DNA double-strand breaks (DSBs) induced by DNA-damaging agents, such as ionizing radiation. DNA DSBs are reco...
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Processing of DNA double-strand break ends, organism-specific biosystem (from REACTOME)
      Processing of DNA double-strand break ends, organism-specific biosystemHomology directed repair (HDR) through homologous recombination (HRR) or single strand annealing (SSA) requires extensive resection of DNA double strand break (DSB) ends (Thompson and Limoli 2003, Ci...
    • Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, organism-specific biosystem (from REACTOME)
      Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, organism-specific biosystemActivated ATM phosphorylates a number of proteins involved in the DNA damage checkpoint and DNA repair (Thompson and Schild 2002, Ciccia and Elledge 2010), thereby triggering and coordinating accumul...
    • SUMO E3 ligases SUMOylate target proteins, organism-specific biosystem (from REACTOME)
      SUMO E3 ligases SUMOylate target proteins, organism-specific biosystemSUMO proteins are conjugated to lysine residues of target proteins via an isopeptide bond with the C-terminal glycine of SUMO (reviewed in Zhao 2007, Gareau and Lima 2010, Hannoun et al. 2010, Citro ...
    • SUMOylation, organism-specific biosystem (from REACTOME)
      SUMOylation, organism-specific biosystemSmall Ubiquitin-like MOdifiers (SUMOs) are a family of 3 proteins (SUMO1,2,3) that are reversibly conjugated to lysine residues of target proteins via a glycine-lysine isopeptide bond (reviewed in Ha...
    • SUMOylation of DNA damage response and repair proteins, organism-specific biosystem (from REACTOME)
      SUMOylation of DNA damage response and repair proteins, organism-specific biosystemSeveral factors that participate in DNA damage response and repair are SUMOylated (reviewed in Dou et al. 2011, Bekker-Jensen and Mailand 2011, Ulrich 2012, Psakhye and Jentsch 2012, Bologna and Ferr...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA0393, DKFZp547P028

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    SUMO binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    guanyl-nucleotide exchange factor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-strand break repair via nonhomologous end joining TAS
    Traceable Author Statement
    more info
     
    intracellular protein transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    centriole IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    E3 ubiquitin-protein ligase HERC2
    Names
    HECT-type E3 ubiquitin transferase HERC2
    hect domain and RCC1-like domain-containing protein 2
    hect domain and RLD 2
    probable E3 ubiquitin-protein ligase HERC2
    NP_004658.3
    XP_005268333.1
    XP_006720789.1
    XP_006720790.1
    XP_011520433.1
    XP_011520435.1
    XP_016878184.1
    XP_016878185.1
    XP_016878186.1
    XP_016878187.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016355.1 RefSeqGene

      Range
      4998..216113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004667.5NP_004658.3  E3 ubiquitin-protein ligase HERC2

      See identical proteins and their annotated locations for NP_004658.3

      Status: REVIEWED

      Source sequence(s)
      AC126332, AC135329, AF071172, AI820017, AK122977, AU100235, AW897649, BC148318, BX440995, CF135750, CX784863, DA868501
      Consensus CDS
      CCDS10021.1
      UniProtKB/Swiss-Prot
      O95714
      UniProtKB/TrEMBL
      A8KAQ8
      Related
      ENSP00000261609.7, OTTHUMP00000159564, ENST00000261609.11, OTTHUMT00000251358
      Conserved Domains (10) summary
      cd08664
      Location:27652910
      APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
      smart00119
      Location:44644790
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:44214792
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd02344
      Location:27062750
      ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
      cd14402
      Location:24602507
      UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
      pfam00173
      Location:12091282
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      pfam00415
      Location:675724
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam06701
      Location:18701929
      MIB_HERC2; Mib_herc2
      pfam11515
      Location:25542631
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      pfam13540
      Location:40394069
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p7 Primary Assembly

      Range
      28111037..28322173 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011522133.2XP_011520435.1  E3 ubiquitin-protein ligase HERC2 isoform X5

      See identical proteins and their annotated locations for XP_011520435.1

      Conserved Domains (10) summary
      cd08664
      Location:16801825
      APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
      smart00119
      Location:33793705
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:33363707
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd02344
      Location:16211665
      ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
      cd14402
      Location:13751422
      UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
      pfam00173
      Location:124197
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      pfam00415
      Location:21902239
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam06701
      Location:785844
      MIB_HERC2; Mib_herc2
      pfam11515
      Location:14691546
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      pfam13540
      Location:29542984
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat
    2. XM_006720727.3XP_006720790.1  E3 ubiquitin-protein ligase HERC2 isoform X3

      See identical proteins and their annotated locations for XP_006720790.1

      Conserved Domains (10) summary
      cd08664
      Location:26792824
      APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
      smart00119
      Location:43784704
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:43354706
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd02344
      Location:26202664
      ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
      cd14402
      Location:23742421
      UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
      pfam00173
      Location:11231196
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      pfam00415
      Location:589638
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam06701
      Location:17841843
      MIB_HERC2; Mib_herc2
      pfam11515
      Location:24682545
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      pfam13540
      Location:39533983
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat
    3. XM_006720726.3XP_006720789.1  E3 ubiquitin-protein ligase HERC2 isoform X1

      See identical proteins and their annotated locations for XP_006720789.1

      Conserved Domains (10) summary
      cd08664
      Location:27602905
      APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
      smart00119
      Location:44594785
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:44164787
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd02344
      Location:27012745
      ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
      cd14402
      Location:24552502
      UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
      pfam00173
      Location:12041277
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      pfam00415
      Location:675724
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam06701
      Location:18651924
      MIB_HERC2; Mib_herc2
      pfam11515
      Location:25492626
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      pfam13540
      Location:40344064
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat
    4. XM_005268276.4XP_005268333.1  E3 ubiquitin-protein ligase HERC2 isoform X2

      See identical proteins and their annotated locations for XP_005268333.1

      Conserved Domains (10) summary
      cd08664
      Location:27272872
      APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
      smart00119
      Location:44264752
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:43834754
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd02344
      Location:26682712
      ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
      cd14402
      Location:24222469
      UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
      pfam00173
      Location:11711244
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      pfam00415
      Location:637686
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam06701
      Location:18321891
      MIB_HERC2; Mib_herc2
      pfam11515
      Location:25162593
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      pfam13540
      Location:40014031
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat
    5. XM_017022695.1XP_016878184.1  E3 ubiquitin-protein ligase HERC2 isoform X2

      Conserved Domains (10) summary
      cd08664
      Location:27272872
      APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
      smart00119
      Location:44264752
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:43834754
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd02344
      Location:26682712
      ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
      cd14402
      Location:24222469
      UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
      pfam00173
      Location:11711244
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      pfam00415
      Location:637686
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam06701
      Location:18321891
      MIB_HERC2; Mib_herc2
      pfam11515
      Location:25162593
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      pfam13540
      Location:40014031
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat
    6. XM_017022696.1XP_016878185.1  E3 ubiquitin-protein ligase HERC2 isoform X2

      Conserved Domains (10) summary
      cd08664
      Location:27272872
      APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
      smart00119
      Location:44264752
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:43834754
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd02344
      Location:26682712
      ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
      cd14402
      Location:24222469
      UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
      pfam00173
      Location:11711244
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      pfam00415
      Location:637686
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam06701
      Location:18321891
      MIB_HERC2; Mib_herc2
      pfam11515
      Location:25162593
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      pfam13540
      Location:40014031
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat
    7. XM_011522131.2XP_011520433.1  E3 ubiquitin-protein ligase HERC2 isoform X4

      See identical proteins and their annotated locations for XP_011520433.1

      Conserved Domains (10) summary
      cd08664
      Location:26042749
      APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
      smart00119
      Location:43034629
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:42604631
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd02344
      Location:25452589
      ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
      cd14402
      Location:22992346
      UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
      pfam00173
      Location:10481121
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      pfam00415
      Location:514563
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam06701
      Location:17091768
      MIB_HERC2; Mib_herc2
      pfam11515
      Location:23932470
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      pfam13540
      Location:38783908
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat
    8. XM_017022697.1XP_016878186.1  E3 ubiquitin-protein ligase HERC2 isoform X6

    9. XM_017022698.1XP_016878187.1  E3 ubiquitin-protein ligase HERC2 isoform X6

    RNA

    1. XR_931930.2 RNA Sequence

    2. XR_001751410.1 RNA Sequence

    Reference GRCh38.p7 PATCHES

    Genomic

    1. NW_011332701.1 Reference GRCh38.p7 PATCHES

      Range
      244501..455590 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_2

    Genomic

    1. NT_187660.1 Reference GRCh38.p7 ALT_REF_LOCI_2

      Range
      244501..569376 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018926.2 Alternate CHM1_1.1

      Range
      28305169..28516258 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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