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    SYMPK symplekin [ Homo sapiens (human) ]

    Gene ID: 8189, updated on 5-Nov-2016
    Official Symbol
    SYMPKprovided by HGNC
    Official Full Name
    symplekinprovided by HGNC
    Primary source
    HGNC:HGNC:22935
    See related
    Ensembl:ENSG00000125755 HPRD:09090; MIM:602388; Vega:OTTHUMG00000150151
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPK; SYM
    Summary
    This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    19q13.32
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (45815442..45863290, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46318700..46366548, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene dystrophia myotonica, WD repeat containing Neighboring gene radial spoke head 6 homolog A Neighboring gene forkhead box A3 Neighboring gene interferon regulatory factor 2 binding protein 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
    • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
      mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
    • mRNA surveillance pathway, conserved biosystem (from KEGG)
      mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ27092

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA polyadenylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004819.2NP_004810.2  symplekin

      See identical proteins and their annotated locations for NP_004810.2

      Status: REVIEWED

      Source sequence(s)
      BC006536, BU752018, DB044963, DB461873, Y10931
      Consensus CDS
      CCDS12676.2
      UniProtKB/Swiss-Prot
      Q92797
      UniProtKB/TrEMBL
      A0A024R0R6
      Related
      ENSP00000245934, OTTHUMP00000196465, ENST00000245934, OTTHUMT00000316581
      Conserved Domains (3) summary
      pfam11935
      Location:121349
      DUF3453; Domain of unknown function (DUF3453)
      pfam12295
      Location:8871068
      Symplekin_C; Symplekin tight junction protein C terminal
      cl21453
      Location:833888
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

      Range
      45815442..45863290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005259286.1XP_005259343.1  

      See identical proteins and their annotated locations for XP_005259343.1

      UniProtKB/Swiss-Prot
      Q92797
      UniProtKB/TrEMBL
      A0A024R0R6
      Conserved Domains (3) summary
      pfam11935
      Location:121349
      DUF3453; Domain of unknown function (DUF3453)
      pfam12295
      Location:8871068
      Symplekin_C; Symplekin tight junction protein C terminal
      cl21453
      Location:833888
      PKc_like; Protein Kinases, catalytic domain
    2. XM_011527354.1XP_011525656.1  

      See identical proteins and their annotated locations for XP_011525656.1

      UniProtKB/Swiss-Prot
      Q92797
      UniProtKB/TrEMBL
      A0A024R0R6
      Conserved Domains (3) summary
      pfam11935
      Location:121349
      DUF3453; Domain of unknown function (DUF3453)
      pfam12295
      Location:8871068
      Symplekin_C; Symplekin tight junction protein C terminal
      cl21453
      Location:833888
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_243962.2 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      46321187..46369025 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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