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    GRIN1 glutamate ionotropic receptor NMDA type subunit 1 [ Homo sapiens (human) ]

    Gene ID: 2902, updated on 6-Dec-2016
    Official Symbol
    GRIN1provided by HGNC
    Official Full Name
    glutamate ionotropic receptor NMDA type subunit 1provided by HGNC
    Primary source
    HGNC:HGNC:4584
    See related
    Ensembl:ENSG00000176884 MIM:138249; Vega:OTTHUMG00000020976
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NR1; MRD8; GluN1; NMDA1; NMD-R1; NMDAR1
    Summary
    The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    9q34.3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 9 NC_000009.12 (137139092..137168762)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (140033609..140063214)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene mannosidase alpha class 1B member 1 Neighboring gene uncharacterized LOC101930307 Neighboring gene dipeptidyl peptidase 7 Neighboring gene uncharacterized LOC105376328 Neighboring gene microRNA 3621 Neighboring gene leucine rich repeat containing 26 Neighboring gene transmembrane protein 210

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Mental retardation, autosomal dominant 8
    MedGen: C3280282 OMIM: 614254 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-induced dephosphorylation of KV2.1 is dependent on NMDA receptor-mediated activation of protein phosphatase 2B or calcineurin PubMed
    env HIV-1 gp120 activates forward trafficking and surface clustering of NMDA receptors in membrane microdomains by a PKA-dependent phosphorylation of the NR1 C-terminal Ser897, followed by a PKC-dependent phosphorylation of Ser896 PubMed
    env HIV-1 gp120-induced synapse loss requires sequential activation of CXCR4, IL-1beta receptor, and NMDA receptor PubMed
    env HIV-1 gp120 activates NMDA receptor directly and phosphorylates JNK through a gp120-mediated apoptotic pathway in human neuroblastoma cells PubMed
    env HIV-1 clade B gp120 significantly downregulates NMDA receptor gene and protein expression and levels of glutamine compared to clade C gp120 PubMed
    env HIV-1 gp120-mediated human cell death involves the NMDA receptor complex; antagonists of the NMDA receptor reverse the gp120-mediated effects PubMed
    env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
    env HIV-1 gp120 binds to cells expressing epsilon1/zeta1 or epsilon2/zeta1 combined NMDA receptor subunits, but not to cells expressing a single epsilon1, epsilon2, or zeta1 NMDA receptor subunit PubMed
    Tat tat The gene expression of GRIN1 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed
    tat Ca(2+) influx through the NMDA receptor is necessary for HIV-1 Tat-induced synapse loss PubMed
    tat HIV-1 Tat-induced dendritic swellings that act in striatal neurons are regulated by NMDA and AMPA receptor-related events PubMed
    tat HIV-1 Tat upregulates the expression of NMDARs for the apoptosis of retinal pigmen epithelium (RPE) cells. Silencing of NMDARs by siRNA abolishes Tat-induced RPE apoptosis PubMed
    tat HIV-1 Tat-induced activation of spermine oxidase (SMO) activity involves NMDAR stimulation in human neuroblastoma PubMed
    tat HIV-1 Tat and methamphetamine inhibit the normal conjunction of signaling between D1 and NMDA receptors, resulting in neural dysfunction and death PubMed
    tat HIV-1 Tat interacts with NMDA receptors in primary neuronal-glial cultures and in hippocampal slice cultures PubMed
    tat Tat treatment causes activation of neuronal nitric oxide synthase (nNOS) through association with NMDA receptors PubMed
    tat HIV-1 Tat treatment induces the formation of complexes involving the low-density lipoprotein receptor-related protein (LRP), postsynaptic density protein-95 (PSD-95), and N-methyl-d-aspartic acid (NMDA) receptors at the neuron surface PubMed
    tat HIV-1 Tat-induced NMDA receptor activation is clade dependent. The Cys 30-Cys 31 motif in Tat is critical for the NMDA receptor activation PubMed
    tat HIV-1 Tat upregulates expression of NMDA receptor 1 in mixed cultures of human neurons and astrocytes PubMed
    tat HIV-1 Tat induces apoptosis of neurons and neurotoxicity through the activation of both NMDA and non-NMDA receptors PubMed

    Go to the HIV-1, Human Interaction Database

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      Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • Signalling to ERKs, organism-specific biosystem (from REACTOME)
      Signalling to ERKs, organism-specific biosystemNeurotrophins utilize multiple pathways to activate ERKs (ERK1 and ERK2), a subgroup of the large MAP kinase (MAPK) family, from the plasma membrane. The major signalling pathways to ERKs are via RAS...
    • Signalling to RAS, organism-specific biosystem (from REACTOME)
      Signalling to RAS, organism-specific biosystemSignalling through Shc adaptor proteins appears to be identical for both NGF and EGF. It leads to a fast, but transient, MAPK/ERK activation, which is insufficient to explain the prolonged activation...
    • Signalling to p38 via RIT and RIN, organism-specific biosystem (from REACTOME)
      Signalling to p38 via RIT and RIN, organism-specific biosystemRIT and RIN are two small guanine nucleotide binding proteins that share more than 50% sequence identity with RAS, including highly conserved core effector domains. Unlike RAS, the C termini of RIT a...
    • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
      Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
    • Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
      Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
    • Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
      Transmission across Chemical Synapses, organism-specific biosystemChemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron,...
    • Unblocking of NMDA receptor, glutamate binding and activation, organism-specific biosystem (from REACTOME)
      Unblocking of NMDA receptor, glutamate binding and activation, organism-specific biosystemAt resting membrane potential the NMDA receptor is blocked by extracellular Mg2+ ions and therefore is not activated in this state by ligands (glutamate, glycine, NMDA). The voltage block is removed ...
    • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
      VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...
    • VEGFR2 mediated cell proliferation, organism-specific biosystem (from REACTOME)
      VEGFR2 mediated cell proliferation, organism-specific biosystemVEGFR2 stimulates ERK not via GRB2-SOS-RAS, but via pY1175-dependent phosphorylation of PLC gamma and subsequent activation of PKCs. PKC plays an important mediatory role in the proliferative Ras/Raf...
    • cAMP signaling pathway, organism-specific biosystem (from KEGG)
      cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cAMP signaling pathway, conserved biosystem (from KEGG)
      cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to NMDA glutamate receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Ras guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
     
    contributes_to calcium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    calmodulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extracellular-glutamate-gated ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    glutamate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glycine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glycine binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neurotransmitter binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    MAPK cascade TAS
    Traceable Author Statement
    more info
     
    adult locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    cation transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    cerebral cortex development IEA
    Inferred from Electronic Annotation
    more info
     
    chemical synaptic transmission TAS
    Traceable Author Statement
    more info
     
    conditioned taste aversion IEA
    Inferred from Electronic Annotation
    more info
     
    ephrin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    excitatory postsynaptic potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ionotropic glutamate receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    long-term memory IEA
    Inferred from Electronic Annotation
    more info
     
    male mating behavior IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    olfactory learning IEA
    Inferred from Electronic Annotation
    more info
     
    pons maturation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of excitatory postsynaptic potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    prepulse inhibition IEA
    Inferred from Electronic Annotation
    more info
     
    propylene metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of axonogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of long-term neuronal synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of respiratory gaseous exchange IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of synapse assembly IEA
    Inferred from Electronic Annotation
    more info
     
    respiratory gaseous exchange IEA
    Inferred from Electronic Annotation
    more info
     
    response to amphetamine IEA
    Inferred from Electronic Annotation
    more info
     
    response to ethanol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to morphine IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    social behavior IEA
    Inferred from Electronic Annotation
    more info
     
    suckling behavior IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic transmission, glutamatergic IEA
    Inferred from Electronic Annotation
    more info
     
    visual learning ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    NMDA selective glutamate receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic spine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    excitatory synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    postsynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    synaptic cleft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    synaptic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    terminal bouton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    glutamate receptor ionotropic, NMDA 1
    Names
    N-methyl-D-aspartate receptor channel, subunit zeta-1
    N-methyl-D-aspartate receptor subunit NR1
    glutamate [NMDA] receptor subunit zeta-1
    glutamate receptor, ionotropic, N-methyl D-aspartate 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011507.1 RefSeqGene

      Range
      5001..34606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000832.6NP_000823.4  glutamate receptor ionotropic, NMDA 1 isoform GluN1-4a precursor

      See identical proteins and their annotated locations for NP_000823.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (GluN1-4a, also known as NR1-1) lacks an alternate in-frame exon and uses an alternate splice site in the 3' coding region, compared to variant GluN1-1a. The resulting protein (isoform GluN1-4a, also known as isoform NR1-1) is shorter and has a different C-terminus, compared to isoform GluN1-1a.
      Source sequence(s)
      AL929554, BU728516, L13266
      Consensus CDS
      CCDS43910.1
      UniProtKB/Swiss-Prot
      Q05586
      Related
      ENSP00000360614, OTTHUMP00000022678, ENST00000371559, OTTHUMT00000055274
      Conserved Domains (5) summary
      cd06379
      Location:8383
      PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      cd13719
      Location:395799
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:561824
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42357
      ANF_receptor; Receptor family ligand binding region
      pfam10562
      Location:835863
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
    2. NM_001185090.1NP_001172019.1  glutamate receptor ionotropic, NMDA 1 isoform GluN1-3b precursor

      See identical proteins and their annotated locations for NP_001172019.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (GluN1-3b, also known as NR1-4) contains an alternate coding segment and uses a different splice site in the 3' coding region, compared to variant GluN1-1a. The resulting protein (isoform GluN1-3b, also known as isoform NR1-4) is longer and has a distinct C-terminus when it is compared to isoform GluN1-1a. This variant has also been named isoform 4b or NMDAR1-4b.
      Source sequence(s)
      AB208999, AF015731, AL929554, BU728516, L13268
      Consensus CDS
      CCDS55354.1
      UniProtKB/Swiss-Prot
      Q05586
      UniProtKB/TrEMBL
      Q59GW0
      Related
      ENSP00000360608, OTTHUMP00000022677, ENST00000371553, OTTHUMT00000055273
      Conserved Domains (6) summary
      cd06379
      Location:8404
      PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      cd13719
      Location:416820
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:582845
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42378
      ANF_receptor; Receptor family ligand binding region
      pfam07885
      Location:623677
      Ion_trans_2; Ion channel
      pfam10562
      Location:856884
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
    3. NM_001185091.1NP_001172020.1  glutamate receptor ionotropic, NMDA 1 isoform GluN1-5b precursor

      See identical proteins and their annotated locations for NP_001172020.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (GluN1-5b, also known as 5) contains an alternate coding segment, lacks a different alternate coding segment, and uses a different splice site in the 3' coding region, compared to variant GluN1-1a. The resulting protein (isoform GluN1-5b, also known as isoform 5) is shorter and has a distinct C-terminus when it is compared to isoform GluN1-1a. This variant has also been named isoform 3b or NMDAR1-3b.
      Source sequence(s)
      AB208999, AF015730, AL929554, BU728516, L13268
      Consensus CDS
      CCDS55355.1
      UniProtKB/Swiss-Prot
      Q05586
      UniProtKB/TrEMBL
      Q59GW0
      Related
      ENSP00000360615, OTTHUMP00000022679, ENST00000371560, OTTHUMT00000055275
      Conserved Domains (5) summary
      cd06379
      Location:8404
      PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      cd13719
      Location:416820
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:582845
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42378
      ANF_receptor; Receptor family ligand binding region
      pfam10562
      Location:856884
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
    4. NM_007327.3NP_015566.1  glutamate receptor ionotropic, NMDA 1 isoform GluN1-1a precursor

      See identical proteins and their annotated locations for NP_015566.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (GluN1-1a, also known as NR1-3) represents the longest transcript and encodes protein isoform GluN1-1a (also known as isoform NR1-3).
      Source sequence(s)
      AL929554, BU728516, D13515
      Consensus CDS
      CCDS7031.1
      UniProtKB/Swiss-Prot
      Q05586
      Related
      ENSP00000360616, OTTHUMP00000022673, ENST00000371561, OTTHUMT00000055267
      Conserved Domains (6) summary
      cd06379
      Location:8383
      PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      cd13719
      Location:395799
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:561824
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42357
      ANF_receptor; Receptor family ligand binding region
      pfam07885
      Location:602656
      Ion_trans_2; Ion channel
      pfam10562
      Location:835863
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
    5. NM_021569.3NP_067544.1  glutamate receptor ionotropic, NMDA 1 isoform GluN1-2a precursor

      See identical proteins and their annotated locations for NP_067544.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (GluN1-2a, also known as NR1-2) lacks an alternate in-frame exon in the 3' coding region, compared to variant GluN1-1a, resulting in a shorter protein (isoform GluN1-2a, also known as isoform NR1-2), compared to isoform GluN1-1a.
      Source sequence(s)
      AL929554, BU728516, D13515, L13267
      Consensus CDS
      CCDS7032.1
      UniProtKB/Swiss-Prot
      Q05586
      Related
      ENSP00000360605, OTTHUMP00000022674, ENST00000371550, OTTHUMT00000055270
      Conserved Domains (5) summary
      cd06379
      Location:8383
      PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      cd13719
      Location:395799
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:561824
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42357
      ANF_receptor; Receptor family ligand binding region
      pfam10562
      Location:835863
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p7 Primary Assembly

      Range
      137139092..137168762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005266073.4XP_005266130.1  

      See identical proteins and their annotated locations for XP_005266130.1

      UniProtKB/Swiss-Prot
      Q05586
      Related
      ENSP00000360601, OTTHUMP00000022675, ENST00000371546, OTTHUMT00000055271
      Conserved Domains (6) summary
      cd06379
      Location:8404
      PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      cd13719
      Location:416820
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:582845
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42378
      ANF_receptor; Receptor family ligand binding region
      pfam07885
      Location:623677
      Ion_trans_2; Ion channel
      pfam10562
      Location:856884
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
    2. XM_005266072.3XP_005266129.1  

      See identical proteins and their annotated locations for XP_005266129.1

      UniProtKB/TrEMBL
      Q5VSF9
      Related
      ENSP00000360610, OTTHUMP00000022676, ENST00000371555, OTTHUMT00000055272
      Conserved Domains (6) summary
      cd06379
      Location:8404
      PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      cd13719
      Location:416820
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:582845
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42378
      ANF_receptor; Receptor family ligand binding region
      pfam07885
      Location:623677
      Ion_trans_2; Ion channel
      pfam10562
      Location:856884
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
    3. XM_011518583.2XP_011516885.1  

      See identical proteins and their annotated locations for XP_011516885.1

      Conserved Domains (5) summary
      cd06379
      Location:8404
      PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      cd13719
      Location:416820
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:582845
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42378
      ANF_receptor; Receptor family ligand binding region
      pfam10562
      Location:856884
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
    4. XM_005266071.3XP_005266128.1  

      See identical proteins and their annotated locations for XP_005266128.1

      UniProtKB/Swiss-Prot
      Q05586
      Conserved Domains (5) summary
      cd06379
      Location:8383
      PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      cd13719
      Location:395799
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:561824
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42357
      ANF_receptor; Receptor family ligand binding region
      pfam10562
      Location:835863
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

    Alternate CHM1_1.1

    Genomic

    1. NC_018920.2 Alternate CHM1_1.1

      Range
      140182355..140211903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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