Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    EST2 Est2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851028, updated on 6-Aug-2017
    Gene symbol
    EST2
    Gene description
    Est2p
    Primary source
    SGD:S000004310
    Locus tag
    YLR318W
    Gene type
    protein coding
    RNA name
    Est2p
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    See EST2 in Map Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (766542..769196)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene septin CDC3 Neighboring gene Nkp2p Neighboring gene Tad3p Neighboring gene Bud6p Neighboring gene Mms22p

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    telomerase RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    telomerase RNA reverse transcriptase activity IEA
    Inferred from Electronic Annotation
    more info
     
    telomerase RNA reverse transcriptase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    contributes_to telomerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    replicative cell aging IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    telomere maintenance via telomerase IDA
    Inferred from Direct Assay
    more info
    PubMed 
    telomere maintenance via telomerase IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    telomerase catalytic core complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    telomerase holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Names
    Est2p
    NP_013422.2
    • Reverse transcriptase subunit of the telomerase holoenzyme; essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      766542..769196
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182207.2NP_013422.2  TPA: Est2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013422.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q06163
      Conserved Domains (2) summary
      smart00975
      Location:282413
      Telomerase_RBD; Telomerase ribonucleoprotein complex - RNA binding domain
      cd01648
      Location:623725
      TERT; TERT: Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as ...
    Support Center