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    Mx1 MX dynamin-like GTPase 1 [ Mus musculus (house mouse) ]

    Gene ID: 17857, updated on 29-Aug-2017
    Official Symbol
    Mx1provided by MGI
    Official Full Name
    MX dynamin-like GTPase 1provided by MGI
    Primary source
    MGI:MGI:97243
    See related
    Ensembl:ENSMUSG00000000386 Vega:OTTMUSG00000016636
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mx; Mx-1; AI893580
    Summary
    This gene encodes a member of the Mx protein family of large GTPases, and functions in the innate immunity system. Interferon alpha/beta treatment or viral infection induces expression of this protein, which subsequently accumulates in the cytoplasm and inhibits viral replication. It has been shown to confer resistance to the influenza virus. This gene produces a functional protein in some feral mouse strains, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a deletion or a nonsense mutation that results in a non-functional gene product. [provided by RefSeq, Aug 2015]
    Orthologs
    Location:
    16 C4; 16 57.46 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (97447035..97462906, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (97668642..97684513, complement)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene DS cell adhesion molecule Neighboring gene predicted gene, 32432 Neighboring gene beta-site APP-cleaving enzyme 2 Neighboring gene family with sequence similarity 3, member B Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene MX dynamin-like GTPase 2

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTP binding TAS
    Traceable Author Statement
    more info
    PubMed 
    GTPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    dynamin family protein polymerization involved in mitochondrial fission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    innate immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    mitochondrial fission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to virus TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    interferon-induced GTP-binding protein Mx1
    Names
    myxoma resistance protein 1
    myxovirus (influenza virus) resistance 1
    myxovirus (influenza) resistance 1 polypeptide

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010846.1NP_034976.1  interferon-induced GTP-binding protein Mx1

      See identical proteins and their annotated locations for NP_034976.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein-coding allele found in the A2G strain.
      Source sequence(s)
      M12279
      UniProtKB/Swiss-Prot
      P09922
      UniProtKB/TrEMBL
      Q4FJJ9
      Conserved Domains (3) summary
      smart00302
      Location:538629
      GED; Dynamin GTPase effector domain
      cd08771
      Location:34306
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:227512
      Dynamin_M; Dynamin central region

    RNA

    1. NR_003520.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the non-functional allele found in the reference strain. This variant lacks a portion of the central coding region, compared to the coding variant (1). This variant is represented as non-coding because there is no evidence for the synthesis of this protein in the reference strain.
      Source sequence(s)
      AK076430, AK150023
      Related
      ENSMUST00000113768.7, OTTMUST00000040247

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      97447035..97462906 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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