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    IXR1 DNA-binding transcription repressor IXR1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853836, updated on 9-Jul-2017
    Gene symbol
    IXR1
    Gene description
    DNA-binding transcription repressor IXR1
    Primary source
    SGD:S000001515
    Locus tag
    YKL032C
    Gene type
    protein coding
    RNA name
    DNA-binding transcription repressor IXR1
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ORD1
    See IXR1 in Map Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (380065..381858, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Tti1p Neighboring gene tRNA Neighboring gene malate dehydrogenase (oxaloacetate-decarboxylating) Neighboring gene transcription factor TFIIE subunit TFA1

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    damaged DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA repair IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to hypoxia IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    colocalizes_with nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    DNA-binding transcription repressor IXR1
    NP_012893.3
    • Transcriptional repressor that regulates hypoxic genes during normoxia; involved in the aerobic repression of genes such as COX5b, TIR1, and HEM13; binds DNA intrastrand cross-links formed by cisplatin; HMG (high mobility group box) domain containing protein which binds and bends cisplatin-modified DNA, blocking excision repair; IXR1 has a paralog, ABF2, that arose from the whole genome duplication

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      380065..381858 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179598.3NP_012893.3  TPA: DNA-binding transcription repressor IXR1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012893.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P33417
      Conserved Domains (2) summary
      COG5648
      Location:338501
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      cd01390
      Location:361423
      HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
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