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    CCK cholecystokinin [ Homo sapiens (human) ]

    Gene ID: 885, updated on 26-Nov-2016
    Official Symbol
    CCKprovided by HGNC
    Official Full Name
    cholecystokininprovided by HGNC
    Primary source
    HGNC:HGNC:1569
    See related
    Ensembl:ENSG00000187094 HPRD:00321; MIM:118440; Vega:OTTHUMG00000131796
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the gastrin/cholecystokinin family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the peptide hormones cholecystokinin-8, -12, -33, and others. The encoded peptides have been shown to regulate gastric acid secretion and food intake. A sulfated form of cholecystokinin-8 may modulate neuronal activity in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
    Orthologs
    Location:
    3p22.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 3 NC_000003.12 (42257824..42266195, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (42299315..42307662, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene trafficking kinesin protein 1 Neighboring gene RNA, U4 small nuclear 78, pseudogene Neighboring gene uncharacterized LOC105377048 Neighboring gene spalt like transcription factor 4 pseudogene 6 Neighboring gene eukaryotic translation initiation factor 4B pseudogene 4

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.
    NHGRI GWA Catalog
    EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children.
    NHGRI GWA Catalog
    • Cell-type Dependent Selectivity of CCK2R Signaling, organism-specific biosystem (from WikiPathways)
      Cell-type Dependent Selectivity of CCK2R Signaling, organism-specific biosystemThis pathway is based on Figure 7 of "Cell-Type Specific CCK2 Receptor Signaling Underlies the Cholecystokinin-Mediated Selective Excitation of Hippocampal Parvalbumin-Positive Fast-Spiking Basket Ce...
    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • Gastric acid production, organism-specific biosystem (from WikiPathways)
      Gastric acid production, organism-specific biosystemGastric acid forms a protective buffer against pathogenic agents. It is also essential in the digestion of the food. The stomach wall is protected to the high acidity by a mucus layer and bicarbonate...
    • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
      Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
    • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
      Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC117187

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    hormone activity TAS
    Traceable Author Statement
    more info
    PubMed 
    neuropeptide hormone activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    axonogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    behavioral fear response IEA
    Inferred from Electronic Annotation
    more info
     
    eating behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    negative regulation of appetite IEA
    Inferred from Electronic Annotation
    more info
     
    neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of glutamate secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of mitochondrial depolarization IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein oligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase C-activating G-protein coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    release of cytochrome c from mitochondria IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    axon ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    axon hillock IEA
    Inferred from Electronic Annotation
    more info
     
    axon initial segment IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    terminal bouton IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    cholecystokinin
    Names
    cholecystokinin triacontatriapeptide
    prepro-cholecystokinin

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000729.5NP_000720.1  cholecystokinin preproprotein

      See identical proteins and their annotated locations for NP_000720.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC018358, BC111026, BI756101, BM544754, CB154424, HY140623
      Consensus CDS
      CCDS2696.1
      UniProtKB/Swiss-Prot
      P06307
      UniProtKB/TrEMBL
      Q6FG82
      Related
      ENSP00000379472, OTTHUMP00000209368, ENST00000396169, OTTHUMT00000343380
      Conserved Domains (1) summary
      pfam00918
      Location:4115
      Gastrin; Gastrin/cholecystokinin family
    2. NM_001174138.2NP_001167609.1  cholecystokinin preproprotein

      See identical proteins and their annotated locations for NP_001167609.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC008283, BI756101
      Consensus CDS
      CCDS2696.1
      UniProtKB/Swiss-Prot
      P06307
      UniProtKB/TrEMBL
      Q6FG82
      Related
      ENSP00000409124, OTTHUMP00000209369, ENST00000434608, OTTHUMT00000343381
      Conserved Domains (1) summary
      pfam00918
      Location:4115
      Gastrin; Gastrin/cholecystokinin family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p7 Primary Assembly

      Range
      42257824..42266195 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      42250423..42258799 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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