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    Sost sclerostin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 80722, updated on 22-Apr-2017
    Official Symbol
    Sostprovided by RGD
    Official Full Name
    sclerostinprovided by RGD
    Primary source
    RGD:69358
    See related
    Ensembl:ENSRNOG00000020805
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    may act as a regulator of bone homeostasis [RGD, Feb 2006]
    Orthologs
    Location:
    10q32.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (89897087..89900131, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (89689512..89692559, complement)

    Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102546446 Neighboring gene mesenchyme homeobox 1 Neighboring gene dual specificity phosphatase 3 Neighboring gene RGD1565533 Neighboring gene membrane palmitoylated protein 3

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to parathyroid hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to parathyroid hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ossification IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of ossification ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    ossification IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    ossification ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    sclerostin
    Names
    sclerosteosis

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030584.1NP_085073.1  sclerostin precursor

      See identical proteins and their annotated locations for NP_085073.1

      Status: PROVISIONAL

      Source sequence(s)
      AF326741
      UniProtKB/Swiss-Prot
      Q99P67
      Related
      ENSRNOP00000028238.1, ENSRNOT00000028238.2
      Conserved Domains (1) summary
      cl21545
      Location:1210
      GHB_like; Glycoprotein hormone beta chain homologues

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

      Range
      89897087..89900131 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000078.1 Alternate Rn_Celera

      Range
      85631705..85634749 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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