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    SET2 histone methyltransferase SET2 [ Saccharomyces cerevisiae S288c ]

    Gene ID: 853271, updated on 9-Apr-2017
    Gene symbol
    SET2
    Gene description
    histone methyltransferase SET2
    Primary source
    SGD:S000003704
    Locus tag
    YJL168C
    Gene type
    protein coding
    RNA name
    histone methyltransferase SET2
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    EZL1; KMT3
    See SET2 in Map Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (102227..104428, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Toh1p Neighboring gene Asg7p Neighboring gene bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase Neighboring gene ubiquinol--cytochrome-c reductase subunit 8

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    histone methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    histone methyltransferase activity (H3-K36 specific) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone methyltransferase activity (H3-K36 specific) IEA
    Inferred from Electronic Annotation
    more info
     
    histone methyltransferase activity (H3-K36 specific) IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone-lysine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA-templated transcription, elongation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-templated transcription, elongation IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-templated transcription, elongation IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    DNA-templated transcription, termination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ascospore formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone H3-K36 methylation IEA
    Inferred from Electronic Annotation
    more info
     
    histone deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone lysine methylation IEA
    Inferred from Electronic Annotation
    more info
     
    histone methylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    methylation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of antisense RNA transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of histone H3-K14 acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of histone H3-K9 acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of histone acetylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of DNA-dependent DNA replication initiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of histone exchange IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Names
    histone methyltransferase SET2
    NP_012367.2
    • Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36 (H3K36), which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain(CTD) of Rpo21p; H3K36me3 (trimethylation) requires Spt6p, proline 38 on H3, CTD of Rpo21p, Ctk1p, and C-terminal SRI domain of Ste2p; relocalizes to the cytosol in response to hypoxia

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      102227..104428 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181601.2NP_012367.2  TPA: histone methyltransferase SET2 [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_012367.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P46995
      Conserved Domains (5) summary
      smart00456
      Location:477507
      WW; Domain with 2 conserved Trp (W) residues
      smart00570
      Location:64119
      AWS; associated with SET domains
      smart00317
      Location:120243
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG2940
      Location:215695
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      pfam08236
      Location:627703
      SRI; SRI (Set2 Rpb1 interacting) domain
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