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    tig peptidyl-prolyl cis/trans isomerase (trigger factor) [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945081, updated on 19-Nov-2016
    Gene symbol
    tig
    Gene description
    peptidyl-prolyl cis/trans isomerase (trigger factor)
    Primary source
    EcoGene:EG11003
    Locus tag
    b0436
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0430; JW0426
    Summary
    dnaK and tig mutants are synthetic lethal at 30 degrees C, however, no lethal effects are observed at 23 degrees C. [More information is available at EcoGene: EG11003]. In Escherichia coli Trigger Factor (TF), the tig gene product, is one of three major (along with DnaK and GroEL) chaperones which cooperate in the folding of newly synthesized cytosolic proteins. . [More information is available at EcoCyc: EG11003].
    Sequence:
    NC_000913.3 (455133..456431)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative lipoprotein Neighboring gene stationary-phase morphogene, transcriptional repressor for mreB; also regulator for dacA, dacC, and ampC Neighboring gene proteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP-dependent serine proteases Neighboring gene ATPase and specificity subunit of ClpX-ClpP ATP-dependent serine protease

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    peptidyl-prolyl cis-trans isomerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding involved in protein folding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ribosome binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ribosome binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    'de novo' cotranslational protein folding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chaperone-mediated protein folding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chaperone-mediated protein folding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein peptidyl-prolyl isomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein unfolding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to heat IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Names
    peptidyl-prolyl cis/trans isomerase (trigger factor)
    NP_414970.1
    • trigger factor; a molecular chaperone involved in cell division

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      455133..456431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414970.1 peptidyl-prolyl cis/trans isomerase (trigger factor) [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414970.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P0A850
      Conserved Domains (4) summary
      PRK01490
      Location:1429
      tig; trigger factor; Provisional
      pfam00254
      Location:154238
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam05697
      Location:6144
      Trigger_N; Bacterial trigger factor protein (TF)
      pfam05698
      Location:262413
      Trigger_C; Bacterial trigger factor protein (TF) C-terminus
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