Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Pou5f1 POU domain, class 5, transcription factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 18999, updated on 19-May-2018
    Official Symbol
    Pou5f1provided by MGI
    Official Full Name
    POU domain, class 5, transcription factor 1provided by MGI
    Primary source
    MGI:MGI:101893
    See related
    Ensembl:ENSMUSG00000024406 Vega:OTTMUSG00000037235
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Oct3; Oct4; Otf3; Otf4; NF-A3; Oct-3; Oct-4; Otf-3; Otf-4; Otf3g; Oct3/4; Oct-3/4; Otf3-rs7
    Summary
    The protein encoded by this gene belongs to the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein plays a key role in embryonic development and stem cell pluripotency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
    Expression
    Biased expression in testis adult (RPKM 4.0) and ovary adult (RPKM 1.5) See more
    Orthologs
    See Pou5f1 in Genome Data Viewer
    Location:
    17 B1; 17 18.69 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (35506032..35510777)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (35642984..35647722)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene histocompatibility 2, Q region locus 10 Neighboring gene predicted gene, 32362 Neighboring gene transcription factor 19 Neighboring gene coiled-coil alpha-helical rod protein 1

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    HMG box domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    POU domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II proximal promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enhancer sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    miRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    BMP signaling pathway involved in heart induction ISO
    Inferred from Sequence Orthology
    more info
     
    blastocyst development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    blastocyst growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cardiac cell fate determination ISO
    Inferred from Sequence Orthology
    more info
     
    cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell fate commitment involved in formation of primary germ layer ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    ectodermal cell fate commitment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endodermal cell fate commitment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endodermal cell fate specification ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    germ-line stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mRNA transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mesodermal cell fate commitment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of calcium ion-dependent exocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of asymmetric cell division IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of heart induction by regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of methylation-dependent chromatin silencing ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    response to organic substance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to retinoic acid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    somatic stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    stem cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    trophectodermal cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IC
    Inferred by Curator
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional repressor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    POU domain, class 5, transcription factor 1
    Names
    POU domain class 5 transcription factor 1 transcript variant 2 oct4b'
    POU domain class 5 transcription factor 1 transcript variant 3 oct4b
    octamer-binding protein 3
    octamer-binding protein 4
    octamer-binding transcription factor 3
    octamer-binding transcription factor 4 alternative

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252452.1NP_001239381.1  POU domain, class 5, transcription factor 1 isoform 2

      See identical proteins and their annotated locations for NP_001239381.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream, in-frame start codon, compared to variant 1. the encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AB375270, AW536651, BY390845
      Conserved Domains (2) summary
      smart00352
      Location:174
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:95148
      Homeobox; Homeobox domain
    2. NM_013633.3NP_038661.2  POU domain, class 5, transcription factor 1 isoform 1

      See identical proteins and their annotated locations for NP_038661.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK145321, BY390845, CR974473
      Consensus CDS
      CCDS37600.1
      UniProtKB/Swiss-Prot
      P20263
      Related
      ENSMUSP00000025271.9, OTTMUSP00000053597, ENSMUST00000025271.16, OTTMUST00000096009
      Conserved Domains (2) summary
      smart00352
      Location:131205
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:226279
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      35506032..35510777
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 129X1/SvJ

    Genomic

    1. NT_039662.3 Reference GRCm38.p4 129X1/SvJ

      Range
      1824981..1829725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_187027.1 Reference GRCm38.p4 NOD/MrkTac

      Range
      1819229..1823763
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center