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    MAP1LC3B microtubule associated protein 1 light chain 3 beta [ Homo sapiens (human) ]

    Gene ID: 81631, updated on 11-Jun-2017
    Official Symbol
    MAP1LC3Bprovided by HGNC
    Official Full Name
    microtubule associated protein 1 light chain 3 betaprovided by HGNC
    Primary source
    HGNC:HGNC:13352
    See related
    Ensembl:ENSG00000140941 MIM:609604; Vega:OTTHUMG00000137654
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LC3B; ATG8F; MAP1LC3B-a; MAP1A/1BLC3
    Summary
    The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    16q24.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 16 NC_000016.10 (87392195..87404774)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (87423157..87438380)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928659 Neighboring gene F-box protein 31 Neighboring gene transfer RNA-Met (CAT) 6-1 Neighboring gene zinc finger CCHC-type containing 14 Neighboring gene nuclear receptor subfamily 3 group C member 1 pseudogene 1 Neighboring gene uncharacterized LOC101928737

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A mega-analysis of genome-wide association studies for major depressive disorder.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Asp asp ASP interacts and colocalizes with LC3b in a punctate manner in COS-7 cells PubMed
    asp HIV-1 ASP expression upregulates the levels of two autophagy markers, LC3b and Beclin 1 in COS-7 cells, suggesting ASP activates autophagy in mammalian cells PubMed
    Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of nucleolin and modulates the expression of LC3, leading to autophage and cell death of uninfected CD4 T cells PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 Env-mediated autophagy induces upregulation of LC3B expression in CD4/X4 HEK cells PubMed
    Nef nef HIV-1 Nef-treated mesenchymal stem cells downregulates the conversion of LC3I to LC3II, reflecting a decrease in autophagic efflux in cells PubMed
    Pr55(Gag) gag HIV-1 Gag fractionates with the cellular cytosol markers LC3A/B and the plasma membrane marker Na-K ATPase in 293T cells PubMed
    gag Protein/protein interactions of virus/autophagy-associated proteins by yeast two-hybrid array reveals the interaction between HIV-1 Gag and microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) PubMed
    Tat tat HIV-1 Tat co-localizes with microtubule-associated protein 1 light chain 3 beta in neuronal cells PubMed
    tat HIV-1 Tat downregulates microtubule-associated protein 1 light chain 3 beta levels in a dose-dependent manner in neuronal cells PubMed
    tat HIV-1 Tat upregulates the levels of BAG3 in human glioblastoma cells, and BAG3 silencing results in highly reducing Tat-induced upregulation of LC3-II and increasing the appearance of sub G0/G1 apoptotic cells PubMed
    tat HIV-1 Tat suppresses IFN-gamma-induced LC3B protein expression and autophagosome formation through Tat-mediated suppression of STAT1 phosphorylation PubMed
    Vif vif HIV-1 Vif binds more strongly to autophagy-related protein 4 (ATG4)-cleaved form I (LC3-I) than to ATG4-cleaved form II (LC3-II) in an A3G-independent manner PubMed
    vif The domain 144-159 inside the SOCS box-like motif of HIV-1 Vif and the glycine 120 of microtubule-associated protein light chain 3 (LC3) are required for the binding between Vif and LC3 PubMed
    vif GST pull-down assay demonstrates that HIV-1 Vif physically interacts with light chain 3 proteins LC3A, LC3B, and LC3C in HEK cells PubMed
    capsid gag HIV-1 CA co-localizes with LC3 in Jurkat cells and primary CD4+ T cells PubMed
    retropepsin gag-pol HIV-1 protease extensively cleaves microtubule-associated proteins 1 and 2 and completely inhibits microtubule assembly PubMed

    Go to the HIV-1, Human Interaction Database

    • Cellular responses to stress, organism-specific biosystem (from REACTOME)
      Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
    • Ferroptosis, organism-specific biosystem (from KEGG)
      Ferroptosis, organism-specific biosystemFerroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compou...
    • Ferroptosis, conserved biosystem (from KEGG)
      Ferroptosis, conserved biosystemFerroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compou...
    • Macroautophagy, organism-specific biosystem (from REACTOME)
      Macroautophagy, organism-specific biosystemMacroautophagy (hereafter referred to as autophagy) acts as a buffer against starvation by liberating building materials and energy sources from cellular components. It has additional roles in embryo...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Mitophagy, organism-specific biosystem (from REACTOME)
      Mitophagy, organism-specific biosystemMitophagy is a specific form of autophagy where mitochondria are specifically targeted for degradation by autophagolysosomes.. In mammals there are a number of known mechanisms of mitophagy. One insu...
    • Pink/Parkin Mediated Mitophagy, organism-specific biosystem (from REACTOME)
      Pink/Parkin Mediated Mitophagy, organism-specific biosystemThis is the process of selective removal of damaged mitochondria by autophagosomes and subsequent catabolism by lysosomes. In healthy mitochondria, PINK1 is imported to the inner mitochondrial membra...
    • Senescence and Autophagy in Cancer, organism-specific biosystem (from WikiPathways)
      Senescence and Autophagy in Cancer, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
    • TBC/RABGAPs, organism-specific biosystem (from REACTOME)
      TBC/RABGAPs, organism-specific biosystemRab GTPases are peripheral membrane proteins involved in membrane trafficking. Often through their indirect interactions with coat components, motors, tethering factors and SNAREs, the Rab GTPases se...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    autophagosome maturation TAS
    Traceable Author Statement
    more info
     
    autophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to nitrogen starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    macroautophagy TAS
    Traceable Author Statement
    more info
     
    membrane organization TAS
    Traceable Author Statement
    more info
     
    mitophagy IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    autophagosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    autophagosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    autophagosome membrane TAS
    Traceable Author Statement
    more info
     
    axoneme ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    endomembrane system IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular IDA
    Inferred from Direct Assay
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    organelle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Preferred Names
    microtubule-associated proteins 1A/1B light chain 3B
    Names
    MAP1 light chain 3-like protein 2
    MAP1A/MAP1B LC3 B
    MAP1A/MAP1B light chain 3 B
    autophagy-related ubiquitin-like modifier LC3 B

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029030.1 RefSeqGene

      Range
      5001..17580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_022818.4NP_073729.1  microtubule-associated proteins 1A/1B light chain 3B

      See identical proteins and their annotated locations for NP_073729.1

      Status: REVIEWED

      Source sequence(s)
      AK025556, AL834298, DA577457, DB055844
      Consensus CDS
      CCDS10960.1
      UniProtKB/Swiss-Prot
      Q9GZQ8
      UniProtKB/TrEMBL
      Q658J6
      Related
      ENSP00000268607.5, OTTHUMP00000175009, ENST00000268607.9, OTTHUMT00000269106
      Conserved Domains (1) summary
      cd01611
      Location:7120
      GABARAP; Ubiquitin domain of GABA-receptor-associated protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p7 Primary Assembly

      Range
      87392195..87404774
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018927.2 Alternate CHM1_1.1

      Range
      88837611..88850167
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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