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    Adipoq adiponectin, C1Q and collagen domain containing [ Mus musculus (house mouse) ]

    Gene ID: 11450, updated on 19-Sep-2017
    Official Symbol
    Adipoqprovided by MGI
    Official Full Name
    adiponectin, C1Q and collagen domain containingprovided by MGI
    Primary source
    MGI:MGI:106675
    See related
    Ensembl:ENSMUSG00000022878 Vega:OTTMUSG00000035780
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ad; APN; Acdc; apM1; 30kDa; GBP28; adipo; Acrp30
    Orthologs
    Location:
    16 B1; 16 13.96 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (23146536..23157968)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (23146609..23158041)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4A2 Neighboring gene small nucleolar RNA, H/ACA box 81 Neighboring gene replication factor C (activator 1) 4 Neighboring gene uncharacterized LOC105246089 Neighboring gene predicted pseudogene 6630 Neighboring gene predicted gene 15746

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • AMPK inhibits chREBP transcriptional activation activity, organism-specific biosystem (from REACTOME)
      AMPK inhibits chREBP transcriptional activation activity, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • AMPK signaling pathway, organism-specific biosystem (from KEGG)
      AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
    • AMPK signaling pathway, conserved biosystem (from KEGG)
      AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
    • Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
      Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
    • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
      Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
    • Adipogenesis genes, organism-specific biosystem (from WikiPathways)
      Adipogenesis genes, organism-specific biosystemThe different classes of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compos...
    • Integration of energy metabolism, organism-specific biosystem (from REACTOME)
      Integration of energy metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Leptin and adiponectin, organism-specific biosystem (from WikiPathways)
      Leptin and adiponectin, organism-specific biosystemProposed mechanism by which leptin and adiponectin stimulate fatty acid oxidation. Adapted from fig 1 in [http://www.ncbi.nlm.nih.gov/pubmed/16497175 Dyck et al.].
    • Longevity regulating pathway, organism-specific biosystem (from KEGG)
      Longevity regulating pathway, organism-specific biosystemRegulation of longevity depends on genetic and environmental factors. Caloric restriction (CR), that is limiting food intake, is recognized in mammals as the best characterized and most reproducible ...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
      Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
    • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
      Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
    • PPAR (Peroxisome proliferator-activated receptor) signaling pathway, organism-specific biosystem (from LIPID MAPS)
      PPAR (Peroxisome proliferator-activated receptor) signaling pathway, organism-specific biosystem
      PPAR (Peroxisome proliferator-activated receptor) signaling pathway
    • PPAR signaling pathway, organism-specific biosystem (from KEGG)
      PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
    • PPAR signaling pathway, conserved biosystem (from KEGG)
      PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
    • PPAR signaling pathway, organism-specific biosystem (from WikiPathways)
      PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
    • Type II diabetes mellitus, organism-specific biosystem (from KEGG)
      Type II diabetes mellitus, organism-specific biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
    • Type II diabetes mellitus, conserved biosystem (from KEGG)
      Type II diabetes mellitus, conserved biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    hormone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hormone activity ISO
    Inferred from Sequence Orthology
    more info
     
    hormone activity TAS
    Traceable Author Statement
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sialic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    adiponectin-activated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    brown fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to cAMP ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to drug IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to epinephrine stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to insulin stimulus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    detection of oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fatty acid beta-oxidation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fatty acid oxidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glucose homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucose metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    low-density lipoprotein particle clearance ISO
    Inferred from Sequence Orthology
    more info
     
    membrane depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    membrane hyperpolarization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gluconeogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of granulocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of low-density lipoprotein particle receptor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of macrophage derived foam cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of macrophage differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of metanephric mesenchymal cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of platelet-derived growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of platelet-derived growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of platelet-derived growth factor receptor-alpha signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cAMP-dependent protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cAMP-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cellular protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of glucose import IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of glycogen (starch) synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of metanephric glomerular visceral epithelial cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of monocyte chemotactic protein-1 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of myeloid cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase A signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of renal albumin absorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of renal albumin absorption ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein heterotrimerization IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    response to glucose IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to glucose IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    collagen trimer IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    adiponectin
    Names
    30 kDa adipocyte complement-related protein
    adipocyte complement related protein
    adipocyte complement-related 30 kDa protein
    adipocyte, C1Q and collagen domain containing
    adipocyte, C1q and collagen domain-containing protein
    adipocyte-specific protein AdipoQ

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009605.5NP_033735.3  adiponectin precursor

      See identical proteins and their annotated locations for NP_033735.3

      Status: VALIDATED

      Source sequence(s)
      AK134112
      Consensus CDS
      CCDS28075.1
      UniProtKB/Swiss-Prot
      Q60994
      Related
      ENSMUSP00000023593.5, OTTMUSP00000050447, ENSMUST00000023593.5, OTTMUST00000091562
      Conserved Domains (2) summary
      smart00110
      Location:112245
      C1Q; Complement component C1q domain
      pfam01391
      Location:45107
      Collagen; Collagen triple helix repeat (20 copies)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      23146536..23157968
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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