Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Unc13a unc-13 homolog A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64829, updated on 8-Apr-2018
    Official Symbol
    Unc13aprovided by RGD
    Official Full Name
    unc-13 homolog Aprovided by RGD
    Primary source
    RGD:619722
    See related
    Ensembl:ENSRNOG00000018452
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Unc13h1; Munc13-1
    Summary
    brain specific protein that may have role during neurotransmitter release [RGD, Feb 2006]
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Biased expression in Brain (RPKM 166.7), Adrenal (RPKM 44.9) and 5 other tissues See more
    Orthologs
    Location:
    16p14
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (20056398..20103951, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 16 NC_005115.3 (19917585..19964219, complement)

    Chromosome 16 - NC_005115.4Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 129, member C Neighboring gene collagen beta(1-O)galactosyltransferase 1 Neighboring gene Janus kinase 3 Neighboring gene insulin-like 3

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Synaptic vesicle cycle, organism-specific biosystem (from KEGG)
      Synaptic vesicle cycle, organism-specific biosystemCommunication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. ...
    • Synaptic vesicle cycle, conserved biosystem (from KEGG)
      Synaptic vesicle cycle, conserved biosystemCommunication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    SNARE binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    calmodulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    diacylglycerol binding IEA
    Inferred from Electronic Annotation
    more info
     
    diacylglycerol binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein N-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spectrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    syntaxin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    syntaxin-1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    syntaxin-1 binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    syntaxin-1 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    amyloid-beta metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    amyloid-beta metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    NOT dense core granule docking ISO
    Inferred from Sequence Orthology
    more info
     
    dense core granule priming IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    dense core granule priming IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    innervation IEA
    Inferred from Electronic Annotation
    more info
     
    innervation ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuromuscular junction development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    neuromuscular junction development IEA
    Inferred from Electronic Annotation
    more info
     
    neuromuscular junction development ISO
    Inferred from Sequence Orthology
    more info
     
    neurotransmitter secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of dendrite extension IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glutamate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of glutamate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neurotransmitter secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neurotransmitter secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    presynaptic dense core vesicle exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    presynaptic dense core vesicle exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    presynaptic dense core vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of amyloid precursor protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of amyloid precursor protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of short-term neuronal synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of short-term neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    synaptic transmission, glutamatergic IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    synaptic vesicle docking IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic vesicle docking ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    synaptic vesicle maturation IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic vesicle maturation ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle priming IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    synaptic vesicle priming IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle priming IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic vesicle priming ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    calyx of Held IEA
    Inferred from Electronic Annotation
    more info
     
    calyx of Held ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    excitatory synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    neuromuscular junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    neuromuscular junction IEA
    Inferred from Electronic Annotation
    more info
     
    neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    presynapse ISO
    Inferred from Sequence Orthology
    more info
     
    presynaptic active zone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    presynaptic active zone IEA
    Inferred from Electronic Annotation
    more info
     
    presynaptic active zone ISO
    Inferred from Sequence Orthology
    more info
     
    presynaptic active zone cytoplasmic component IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    presynaptic active zone cytoplasmic component IDA
    Inferred from Direct Assay
    more info
    PubMed 
    presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    terminal bouton HDA PubMed 
    terminal bouton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    terminal bouton IDA
    Inferred from Direct Assay
    more info
    PubMed 

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022861.1NP_074052.1  protein unc-13 homolog A

      See identical proteins and their annotated locations for NP_074052.1

      Status: PROVISIONAL

      Source sequence(s)
      U24070
      UniProtKB/Swiss-Prot
      Q62768
      Related
      ENSRNOP00000025162.7, ENSRNOT00000025162.8
      Conserved Domains (6) summary
      cd04027
      Location:689815
      C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
      cd08394
      Location:1127
      C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
      cd08395
      Location:15781697
      C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
      cd00029
      Location:567616
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam06292
      Location:10071115
      DUF1041; Domain of Unknown Function (DUF1041)
      pfam10540
      Location:13601521
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005115.4 Reference Rnor_6.0 Primary Assembly

      Range
      20056398..20103951 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000084.1 Alternate Rn_Celera

      Range
      18539912..18584310 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center