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    Syt1 synaptotagmin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25716, updated on 4-Jun-2017
    Official Symbol
    Syt1provided by RGD
    Official Full Name
    synaptotagmin 1provided by RGD
    Primary source
    RGD:3803
    See related
    Ensembl:ENSRNOG00000006426
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    P65
    Summary
    integral component of synaptic vesicle membranes; important for exocytosis and vesicle trafficking to the active zone of synapses; may be the calcium sensor for calcium-dependent exocytosis [RGD, Feb 2006]
    Orthologs
    Location:
    7q21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (50084063..50638996, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (50097034..50289950, complement)

    Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549995 Neighboring gene protein tyrosine phosphatase, receptor type, Q Neighboring gene otogelin-like protein-like Neighboring gene uncharacterized LOC102547595 Neighboring gene lys-63-specific deubiquitinase BRCC36-like Neighboring gene uncharacterized LOC108351599 Neighboring gene high mobility group protein B1 pseudogene Neighboring gene 60S ribosomal protein L31-like Neighboring gene similar to histone deacetylase 1 Neighboring gene 60S ribosomal protein L26-like Neighboring gene pro-apoptotic WT1 regulator

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    SNARE binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SNARE binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium ion binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    calcium-dependent phospholipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium-dependent phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    calmodulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    clathrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    low-density lipoprotein particle receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    low-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylserine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phospholipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity TAS
    Traceable Author Statement
    more info
    PubMed 
    syntaxin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    syntaxin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    syntaxin-1 binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    syntaxin-1 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    syntaxin-1 binding ISO
    Inferred from Sequence Orthology
    more info
     
    syntaxin-3 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    brain development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    calcium ion regulated exocytosis TAS
    Traceable Author Statement
    more info
    PubMed 
    calcium ion-regulated exocytosis of neurotransmitter IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cellular response to calcium ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    detection of calcium ion IC
    Inferred by Curator
    more info
    PubMed 
    detection of calcium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fast, calcium ion-dependent exocytosis of neurotransmitter ISO
    Inferred from Sequence Orthology
    more info
     
    fast, calcium ion-dependent exocytosis of neurotransmitter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neurotransmitter secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of calcium ion-dependent exocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of dendrite extension IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synaptic transmission ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of vesicle fusion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein heterooligomerization IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homooligomerization IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    regulation of calcium ion-dependent exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of calcium ion-dependent exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of dopamine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of dopamine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of regulated secretory pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synaptic transmission, glutamatergic ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to calcium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    synaptic vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle exocytosis TAS
    Traceable Author Statement
    more info
    PubMed 
    vesicle docking IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with SNARE complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    chromaffin granule membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    dense core granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dense core granule ISO
    Inferred from Sequence Orthology
    more info
     
    excitatory synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    terminal bouton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    synaptotagmin-1
    Names
    synaptotagmin I
    sytI

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033680.2NP_001028852.2  synaptotagmin-1

      See identical proteins and their annotated locations for NP_001028852.2

      Status: VALIDATED

      Source sequence(s)
      AA924659, AJ617621, CB615786, CB731032, CO398869
      UniProtKB/Swiss-Prot
      P21707
      UniProtKB/TrEMBL
      Q707P0
      Related
      ENSRNOP00000049624.2, ENSRNOT00000048880.2
      Conserved Domains (2) summary
      cd08385
      Location:142264
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08402
      Location:273408
      C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

      Range
      50084063..50638996 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594679.1XP_017450168.1  synaptotagmin-1 isoform X1

      UniProtKB/Swiss-Prot
      P21707
      Related
      ENSRNOP00000069194.1, ENSRNOT00000088950.1
      Conserved Domains (2) summary
      cd08385
      Location:142264
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08402
      Location:273408
      C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
    2. XM_008765353.2XP_008763575.2  synaptotagmin-1 isoform X2

    Alternate Rn_Celera

    Genomic

    1. AC_000075.1 Alternate Rn_Celera

      Range
      40680324..41216966 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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