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    MOG myelin oligodendrocyte glycoprotein [ Homo sapiens (human) ]

    Gene ID: 4340, updated on 5-Nov-2017
    Official Symbol
    MOGprovided by HGNC
    Official Full Name
    myelin oligodendrocyte glycoproteinprovided by HGNC
    Primary source
    HGNC:HGNC:7197
    See related
    Ensembl:ENSG00000204655 MIM:159465; Vega:OTTHUMG00000031099
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BTN6; BTNL11; MOGIG2; NRCLP7
    Summary
    The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    6p22.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 6 NC_000006.12 (29656981..29672372)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (29624758..29640149)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid type B receptor subunit 1 Neighboring gene SUMO2 pseudogene 1 Neighboring gene ZFP57 zinc finger protein Neighboring gene zinc finger DHHC-type containing 20 pseudogene 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Narcolepsy 7
    MedGen: C3280266 OMIM: 614250 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
    NHGRI GWA Catalog
    Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC26137

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    central nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    viral entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    myelin-oligodendrocyte glycoprotein
    Names
    MOG AluA
    MOG AluB
    MOG Ig-AluB
    MOG alpha-5

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031873.1 RefSeqGene

      Range
      5001..20392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001008228.2NP_001008229.1  myelin-oligodendrocyte glycoprotein isoform alpha3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha3) has multiple differences in the coding region, compared to variant beta1. Alpha type variants use an alternative splice site at the 3' end, compared to isoform beta1. The resulting isoform (alpha3) is shorter and contains a shorter and distinct C-terminus, compared to isoform beta1.
      Source sequence(s)
      AL119259, DA139582, DA140757, DA253273, U18843, U64564
      Consensus CDS
      CCDS34369.1
      UniProtKB/Swiss-Prot
      Q16653
      Related
      ENSP00000379932.3, OTTHUMP00000029127, ENST00000396704.7, OTTHUMT00000076161
      Conserved Domains (2) summary
      cd05713
      Location:46144
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:40144
      IG_like; Immunoglobulin like
    2. NM_001008229.2NP_001008230.1  myelin-oligodendrocyte glycoprotein isoform beta2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (beta2) lacks an in-frame segment of the coding region, compared to variant beta1. It encodes a shorter isoform (beta2), that is missing an internal segment, compared to isoform beta1.
      Source sequence(s)
      AL119259, AY566853, DA139582, DA140757, DA253273, U64564
      Consensus CDS
      CCDS34368.1
      UniProtKB/Swiss-Prot
      Q16653
      Related
      ENSP00000366088.4, OTTHUMP00000029121, ENST00000376891.8, OTTHUMT00000076155
      Conserved Domains (2) summary
      cd05713
      Location:46144
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:40144
      IG_like; Immunoglobulin like
    3. NM_001170418.1NP_001163889.1  myelin-oligodendrocyte glycoprotein isoform alpha6 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha6) lacks an alternate in-frame exon in the 5' coding region and differs in the 3' coding region and 3' UTR, compared to variant beta1. The encoded isoform (alpha6) has a distinct C-terminus and is shorter than isoform beta1.
      Source sequence(s)
      AL119259, AY566847, DA139582, DA140757, DA253273, U64564
      Consensus CDS
      CCDS54977.1
      UniProtKB/Swiss-Prot
      Q16653
      Related
      ENSP00000420350.1, OTTHUMP00000214868, ENST00000490427.5, OTTHUMT00000354636
    4. NM_002433.4NP_002424.3  myelin-oligodendrocyte glycoprotein isoform beta1 precursor

      See identical proteins and their annotated locations for NP_002424.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (beta1) encodes the longest isoform (beta1), also known as isoform 1.
      Source sequence(s)
      AL119259, AY566852, DA139582, DA140757, DA253273, U64564
      Consensus CDS
      CCDS4667.1
      UniProtKB/Swiss-Prot
      Q16653
      UniProtKB/TrEMBL
      Q5SSB8
      Related
      ENSP00000366095.3, OTTHUMP00000029122, ENST00000376898.7, OTTHUMT00000076156
      Conserved Domains (2) summary
      cd05713
      Location:46144
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:40144
      IG_like; Immunoglobulin like
    5. NM_206809.3NP_996532.2  myelin-oligodendrocyte glycoprotein isoform alpha1 precursor

      See identical proteins and their annotated locations for NP_996532.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha1) contains an additional segment in the coding region compared to variant beta1. Alpha type variants use an alternative splice site at the 3' end, compared to variant beta1. The resulting isoform (alpha1), also known as isoform 2, contains a shorter and distinct C-terminus compared to isoform beta1.
      Source sequence(s)
      AL119259, DA139582, DA140757, DA253273, U64564, X74511
      Consensus CDS
      CCDS34370.1
      UniProtKB/Swiss-Prot
      Q16653
      Related
      ENSP00000366115.3, OTTHUMP00000029126, ENST00000376917.7, OTTHUMT00000076160
      Conserved Domains (2) summary
      cd05713
      Location:46144
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:40144
      IG_like; Immunoglobulin like
    6. NM_206810.3NP_996533.2  myelin-oligodendrocyte glycoprotein isoform beta5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (beta5) lacks an in-frame segment of the coding region, compared to variant beta1. It encodes a shorter isoform (beta5), also known as isoform 3, that is missing an internal segment, compared to isoform beta1.
      Source sequence(s)
      AL119259, DA139582, DA140757, DA253273, U18803, U64564
      Consensus CDS
      CCDS34367.1
      UniProtKB/Swiss-Prot
      Q16653
      Related
      ENSP00000379929.2, OTTHUMP00000029124, ENST00000396701.6, OTTHUMT00000076158
      Conserved Domains (2) summary
      cd05713
      Location:46144
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:40144
      IG_like; Immunoglobulin like
    7. NM_206811.3NP_996534.2  myelin-oligodendrocyte glycoprotein isoform beta3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (beta3) has multiple differences in the coding region, compared to variant beta1. The resulting isoform (beta3), also known as isoform 4, is shorter, compared to isoform beta1.
      Source sequence(s)
      AL119259, DA139582, DA140757, DA253273, U18840, U64564
      Consensus CDS
      CCDS34366.1
      UniProtKB/Swiss-Prot
      Q16653
      Related
      ENSP00000417405.1, OTTHUMP00000029125, ENST00000494692.5, OTTHUMT00000076159
      Conserved Domains (2) summary
      cd05713
      Location:46144
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:40144
      IG_like; Immunoglobulin like
    8. NM_206812.3NP_996535.2  myelin-oligodendrocyte glycoprotein isoform alpha2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha2) has multiple differences in the coding region, compared to variant beta1. Alpha type variants use an alternative splice site at the 3' end, compared to isoform beta1. The resulting isoform (alpha2), also known as isoform 5, is shorter and contains a shorter and distinct C-terminus, compared to isoform beta1.
      Source sequence(s)
      AL119259, DA139582, DA140757, DA253273, U18799, U64564
      Consensus CDS
      CCDS47394.1
      UniProtKB/Swiss-Prot
      Q16653
      Related
      ENSP00000410866.2, OTTHUMP00000029123, ENST00000431798.6, OTTHUMT00000076157
      Conserved Domains (2) summary
      cd05713
      Location:46144
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:40144
      IG_like; Immunoglobulin like
    9. NM_206814.5NP_996537.3  myelin-oligodendrocyte glycoprotein isoform alpha5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha5) lacks an alternate in-frame exon in the 5' coding region and differs in the 3' coding region and 3' UTR, compared to variant beta1. The encoded isoform (alpha5) has a distinct C-terminus and is shorter than isoform beta1.
      Source sequence(s)
      AK308949, AL119259, DA139582, DA140757, DA253273, U64564
      Consensus CDS
      CCDS47395.2
      UniProtKB/Swiss-Prot
      Q16653
      Related
      ENSP00000366085.2, OTTHUMP00000029120, ENST00000376888.6, OTTHUMT00000076154

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p7 Primary Assembly

      Range
      29656981..29672372
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005249131.3XP_005249188.1  myelin-oligodendrocyte glycoprotein isoform X1

      UniProtKB/Swiss-Prot
      Q16653
      Related
      ENSP00000366091.4, OTTHUMP00000109158, ENST00000376894.8, OTTHUMT00000194941
      Conserved Domains (2) summary
      cd05713
      Location:46144
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:40144
      IG_like; Immunoglobulin like

    Reference GRCh38.p7 ALT_REF_LOCI_1

    Genomic

    1. NT_167244.2 Reference GRCh38.p7 ALT_REF_LOCI_1

      Range
      922690..938080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.3 Reference GRCh38.p7 ALT_REF_LOCI_2

      Range
      1143453..1158845
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.2 Reference GRCh38.p7 ALT_REF_LOCI_3

      Range
      922526..937918
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.2 Reference GRCh38.p7 ALT_REF_LOCI_4

      Range
      922098..937486
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.2 Reference GRCh38.p7 ALT_REF_LOCI_5

      Range
      922362..937746
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.2 Reference GRCh38.p7 ALT_REF_LOCI_6

      Range
      922481..937873
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.2 Reference GRCh38.p7 ALT_REF_LOCI_7

      Range
      966016..981404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018917.2 Alternate CHM1_1.1

      Range
      29626856..29642241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_206813.4: Suppressed sequence

      Description
      NM_206813.4: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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