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    AURKB aurora kinase B [ Homo sapiens (human) ]

    Gene ID: 9212, updated on 1-Dec-2016
    Official Symbol
    AURKBprovided by HGNC
    Official Full Name
    aurora kinase Bprovided by HGNC
    Primary source
    HGNC:HGNC:11390
    See related
    Ensembl:ENSG00000178999 HPRD:05397; MIM:604970; Vega:OTTHUMG00000108189
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; STK12; PPP1R48; aurkb-sv1; aurkb-sv2
    Summary
    This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]
    Orthologs
    Location:
    17p13.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (8204731..8210768, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8108049..8113944, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene transfer RNA-Ile (AAT) 5-5 Neighboring gene BLOC-1 related complex subunit 6 Neighboring gene transfer RNA-Trp (CCA) 1-1 Neighboring gene long intergenic non-protein coding RNA 324 Neighboring gene transfer RNA-Gly (TCC) 3-1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr AurB and INCENP proteins targeting the inner centromere are reduced significantly in HIV-1 Vpr-expressing prometaphase cells PubMed

    Go to the HIV-1, Human Interaction Database

    • APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem (from REACTOME)
      APC/C-mediated degradation of cell cycle proteins, organism-specific biosystemThe Anaphase Promoting Complex or Cyclosome (APC/C) functions during mitosis to promote sister chromatid separation and mitotic exit through the degradation of mitotic cyclins and securin. This compl...
    • APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem (from REACTOME)
      APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystemFrom late mitosis through G1 phase APC/C:Cdh1 insures the continued degradation of the mitotic proteins and during mitotic exit and G1 its substrates include Cdc20, Plk1, Aurora A, Cdc6 and Gemin...
    • ATM Signaling Network in Development and Disease, organism-specific biosystem (from WikiPathways)
      ATM Signaling Network in Development and Disease, organism-specific biosystemThis pathway is modeled after Figure 4 in the article "The ATM signaling network in development and disease" (See Bibliography). When DNA is damaged, DDR begins to work on recuperating the damage th...
    • Aurora A signaling, organism-specific biosystem (from Pathway Interaction Database)
      Aurora A signaling, organism-specific biosystem
      Aurora A signaling
    • Aurora B signaling, organism-specific biosystem (from Pathway Interaction Database)
      Aurora B signaling, organism-specific biosystem
      Aurora B signaling
    • Aurora C signaling, organism-specific biosystem (from Pathway Interaction Database)
      Aurora C signaling, organism-specific biosystem
      Aurora C signaling
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • FOXM1 transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      FOXM1 transcription factor network, organism-specific biosystem
      FOXM1 transcription factor network
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • M Phase, organism-specific biosystem (from REACTOME)
      M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Mitotic Anaphase, organism-specific biosystem (from REACTOME)
      Mitotic Anaphase, organism-specific biosystemIn anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement al...
    • Mitotic Metaphase and Anaphase, organism-specific biosystem (from REACTOME)
      Mitotic Metaphase and Anaphase, organism-specific biosystemMetaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ...
    • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
      Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and th...
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
      RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
    • RHO GTPases Activate Formins, organism-specific biosystem (from REACTOME)
      RHO GTPases Activate Formins, organism-specific biosystemFormins are a family of proteins with 15 members in mammals, organized into 8 subfamilies. Formins are involved in the regulation of actin cytoskeleton. Many but not all formin family members are act...
    • Regulation of TP53 Activity, organism-specific biosystem (from REACTOME)
      Regulation of TP53 Activity, organism-specific biosystemProtein stability and transcriptional activity of TP53 (p53) tumor suppressor are regulated by post-translational modifications that include ubiquitination, phosphorylation, acetylation, methylation,...
    • Regulation of TP53 Activity through Phosphorylation, organism-specific biosystem (from REACTOME)
      Regulation of TP53 Activity through Phosphorylation, organism-specific biosystemPhosphorylation of TP53 (p53) at the N-terminal serine residues S15 and S20 plays a critical role in protein stabilization as phosphorylation at these sites interferes with binding of the ubiquitin l...
    • Regulation of mitotic cell cycle, organism-specific biosystem (from REACTOME)
      Regulation of mitotic cell cycle, organism-specific biosystem
      Regulation of mitotic cell cycle
    • Resolution of Sister Chromatid Cohesion, organism-specific biosystem (from REACTOME)
      Resolution of Sister Chromatid Cohesion, organism-specific biosystemThe resolution of sister chromatids in mitotic prometaphase involves removal of cohesin complexes from chromosomal arms, with preservation of cohesion at centromeres (Losada et al. 1998, Hauf et al. ...
    • SUMO E3 ligases SUMOylate target proteins, organism-specific biosystem (from REACTOME)
      SUMO E3 ligases SUMOylate target proteins, organism-specific biosystemSUMO proteins are conjugated to lysine residues of target proteins via an isopeptide bond with the C-terminal glycine of SUMO (reviewed in Zhao 2007, Gareau and Lima 2010, Hannoun et al. 2010, Citro ...
    • SUMOylation, organism-specific biosystem (from REACTOME)
      SUMOylation, organism-specific biosystemSmall Ubiquitin-like MOdifiers (SUMOs) are a family of 3 proteins (SUMO1,2,3) that are reversibly conjugated to lysine residues of target proteins via a glycine-lysine isopeptide bond (reviewed in Ha...
    • SUMOylation of DNA replication proteins, organism-specific biosystem (from REACTOME)
      SUMOylation of DNA replication proteins, organism-specific biosystemThe sliding clamp protein PCNA, Aurora-A, Aurora-B, Borealin, and various topoisomerases can be SUMOylated (reviewed in Wan et al. 2012). SUMOylation of PCNA appears to reduce formation of double-str...
    • Separation of Sister Chromatids, organism-specific biosystem (from REACTOME)
      Separation of Sister Chromatids, organism-specific biosystemWhile sister chromatids resolve in prometaphase, separating along chromosomal arms, the cohesion of sister centromeres persists until anaphase. At the anaphase onset, the anaphase promoting complex/c...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Aurora kinases, organism-specific biosystem (from Pathway Interaction Database)
      Signaling by Aurora kinases, organism-specific biosystem
      Signaling by Aurora kinases
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
      Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    histone serine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    histone serine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    protein serine/threonine/tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    abscission ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    aging IEA
    Inferred from Electronic Annotation
    more info
     
    anaphase-promoting complex-dependent catabolic process TAS
    Traceable Author Statement
    more info
     
    attachment of spindle microtubules to kinetochore TAS
    Traceable Author Statement
    more info
    PubMed 
    cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to UV IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cleavage furrow formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone H3-S28 phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    histone modification TAS
    Traceable Author Statement
    more info
    PubMed 
    mitotic spindle midzone assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic spindle midzone assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of B cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cytokinesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytokinesis TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of telomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of telomere capping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of telomere maintenance via telomerase IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    protein localization to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein sumoylation TAS
    Traceable Author Statement
    more info
     
    protein ubiquitination involved in ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
     
    regulation of chromosome segregation TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of signal transduction by p53 class mediator TAS
    Traceable Author Statement
    more info
     
    sister chromatid cohesion TAS
    Traceable Author Statement
    more info
     
    spindle checkpoint IEA
    Inferred from Electronic Annotation
    more info
     
    spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    chromocenter IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome passenger complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    chromosome passenger complex TAS
    Traceable Author Statement
    more info
    PubMed 
    condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    condensed nuclear chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    intercellular bridge IDA
    Inferred from Direct Assay
    more info
     
    colocalizes_with kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    midbody TAS
    Traceable Author Statement
    more info
    PubMed 
    mitotic spindle midzone IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spindle TAS
    Traceable Author Statement
    more info
    PubMed 
    spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    spindle pole centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    aurora kinase B
    Names
    ARK-2
    STK-1
    aurora kinase B-Sv1
    aurora kinase B-Sv2
    aurora- and Ipl1-like midbody-associated protein 1
    aurora-1
    aurora-B
    aurora-related kinase 2
    aurora/IPL1-related kinase 2
    protein phosphatase 1, regulatory subunit 48
    serine/threonine kinase 12
    serine/threonine-protein kinase 12
    serine/threonine-protein kinase 5
    serine/threonine-protein kinase aurora-B
    NP_001243763.1
    NP_001271455.1
    NP_001300879.1
    NP_001300880.1
    NP_001300881.1
    NP_001300882.1
    NP_001300883.1
    NP_001300884.1
    NP_004208.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256834.2NP_001243763.1  aurora kinase B isoform 2

      See identical proteins and their annotated locations for NP_001243763.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' coding region, which results in translation initiation from an in-frame downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 5 encode the same isoform.
      Source sequence(s)
      AK297976, BC009751, BE514591, BP225027
      Consensus CDS
      CCDS58514.1
      UniProtKB/Swiss-Prot
      Q96GD4
      Related
      ENSP00000443869, OTTHUMP00000259370, ENST00000534871, OTTHUMT00000441844
      Conserved Domains (2) summary
      smart00220
      Location:36286
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:29298
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001284526.1NP_001271455.1  aurora kinase B isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame acceptor splice site in the mid-coding region compared to variant 1. The resulting isoform (3) is one amino acid longer than isoform 1.
      Source sequence(s)
      BC009751, BC013300, BE514591, BP225027
      Consensus CDS
      CCDS67162.1
      UniProtKB/Swiss-Prot
      Q96GD4
      Related
      ENSP00000313950, OTTHUMP00000259369, ENST00000316199, OTTHUMT00000441842
      Conserved Domains (2) summary
      smart00220
      Location:78328
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:71340
      PKc_like; Protein Kinases, catalytic domain
    3. NM_001313950.1NP_001300879.1  aurora kinase B isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate acceptor splice site in the 5' non-coding region compared to variant 1. Variants 4 and 1 encode the same isoform (1).
      Source sequence(s)
      BC009751, BE514591, BP225027, CX781462
      Consensus CDS
      CCDS11134.1
      UniProtKB/Swiss-Prot
      Q96GD4
      Conserved Domains (2) summary
      smart00220
      Location:77327
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:70339
      PKc_like; Protein Kinases, catalytic domain
    4. NM_001313951.1NP_001300880.1  aurora kinase B isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains a novel exon in the 5' region, which results in translation initiation from an in-frame downstream start codon compared to variant 1. Variants 5 and 2 encode the same isoform (2).
      Source sequence(s)
      BC009751, BE797606, BP225027
      Consensus CDS
      CCDS58514.1
      UniProtKB/Swiss-Prot
      Q96GD4
      Conserved Domains (2) summary
      smart00220
      Location:36286
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:29298
      PKc_like; Protein Kinases, catalytic domain
    5. NM_001313952.1NP_001300881.1  aurora kinase B isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an exon in the 5' coding region and uses two alternate acceptor splice sites in the mid-region compared to variant 1. The encoded isoform (4), resulting from use of an in-frame downstream start codon, has a shorter N-terminus and and an extra amino acid in the mid-region compared to isoform 1.
      Source sequence(s)
      BC009751, BE514591, BM905813, BP225027
      UniProtKB/Swiss-Prot
      Q96GD4
      Conserved Domains (2) summary
      smart00220
      Location:37287
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:30299
      PKc_like; Protein Kinases, catalytic domain
    6. NM_001313953.1NP_001300882.1  aurora kinase B isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) uses alternate in-frame donor and acceptor splices sites in the mid-coding region compared to variant 1. The resulting isoform (5) is shorter containing a 16 aa protein segment not found in isoform 1.
      Source sequence(s)
      AB519678, AY677083, BC009751
      Consensus CDS
      CCDS82065.1
      UniProtKB/Swiss-Prot
      Q96GD4
      Related
      ENSP00000462207, OTTHUMP00000259372, ENST00000578549, OTTHUMT00000441846
      Conserved Domains (2) summary
      smart00220
      Location:102295
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:70307
      PKc_like; Protein Kinases, catalytic domain
    7. NM_001313954.1NP_001300883.1  aurora kinase B isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) uses an alternate donor splice site in the mid-region compared to variant 1. It represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render this transcript variant a candidate for nonsense-mediated mRNA decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG, which would result in an isoform (6) that is shorter, with a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AF004022, BC009751, BE514591, BP225027, BU181480
      UniProtKB/Swiss-Prot
      Q96GD4
      Conserved Domains (2) summary
      smart00220
      Location:27175
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:21187
      PKc_like; Protein Kinases, catalytic domain
    8. NM_001313955.1NP_001300884.1  aurora kinase B isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks two non-consecutive exons in the 5' and mid-region and uses an alternate donor splice site in the mid-region, compared to variant 1. It represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render this transcript variant a candidate for nonsense-mediated mRNA decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG, which would result in an isoform (7) that is shorter, with a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      BC009751, BE514591, BI199088, BP225027
      UniProtKB/Swiss-Prot
      Q96GD4
      Conserved Domains (2) summary
      smart00220
      Location:10159
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:10171
      PKc_like; Protein Kinases, catalytic domain
    9. NM_004217.3NP_004208.2  aurora kinase B isoform 1

      See identical proteins and their annotated locations for NP_004208.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes the predominant isoform (1). Variants 1 and 4 encode the same isoform.
      Source sequence(s)
      AC135178, BC000442, BC009751
      Consensus CDS
      CCDS11134.1
      UniProtKB/Swiss-Prot
      Q96GD4
      Related
      ENSP00000463999, OTTHUMP00000135331, ENST00000585124, OTTHUMT00000226995
      Conserved Domains (2) summary
      smart00220
      Location:77327
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:70339
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. NR_132730.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) uses an alternate donor splice site in the mid-region compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript variant a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC009751, BE514591, BP225027, CN286704
    2. NR_132731.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) lacks an internal exon and uses an alternate acceptor splice site in the mid-region compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript variant a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AY677083, BC009751

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

      Range
      8204731..8210768 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017025307.1XP_016880796.1  

      UniProtKB/Swiss-Prot
      Q96GD4
      Conserved Domains (2) summary
      smart00220
      Location:36286
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:29298
      PKc_like; Protein Kinases, catalytic domain
    2. XM_017025308.1XP_016880797.1  

    3. XM_011524072.2XP_011522374.1  

      See identical proteins and their annotated locations for XP_011522374.1

      UniProtKB/Swiss-Prot
      Q96GD4
      Conserved Domains (2) summary
      smart00220
      Location:36286
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:29298
      PKc_like; Protein Kinases, catalytic domain
    4. XM_011524070.2XP_011522372.1  

      See identical proteins and their annotated locations for XP_011522372.1

      UniProtKB/Swiss-Prot
      Q96GD4
      Conserved Domains (2) summary
      smart00220
      Location:102295
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:70307
      PKc_like; Protein Kinases, catalytic domain
    5. XM_017025310.1XP_016880799.1  

      Conserved Domains (2) summary
      smart00220
      Location:27175
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:21187
      PKc_like; Protein Kinases, catalytic domain
    6. XM_017025309.1XP_016880798.1  

      Conserved Domains (2) summary
      smart00220
      Location:27175
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:21187
      PKc_like; Protein Kinases, catalytic domain
    7. XM_017025311.1XP_016880800.1  

      Conserved Domains (2) summary
      smart00220
      Location:27175
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:21187
      PKc_like; Protein Kinases, catalytic domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      8117184..8123078 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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