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    Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) [ Mus musculus (house mouse) ]

    Gene ID: 11444, updated on 12-Nov-2017
    Official Symbol
    Chrnb2provided by MGI
    Official Full Name
    cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)provided by MGI
    Primary source
    MGI:MGI:87891
    See related
    Ensembl:ENSMUSG00000027950 Vega:OTTMUSG00000052879
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Acrb2; Acrb-2; [b]2-nAchR; C030030P04Rik
    Orthologs
    Location:
    3 F1; 3 39.19 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (89753448..89764632, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (89557370..89568554, complement)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene phosphomevalonate kinase Neighboring gene potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 Neighboring gene adenosine deaminase, RNA-specific Neighboring gene RIKEN cDNA 4632404H12 gene Neighboring gene ubiquitin-conjugating enzyme E2Q family member 1

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to acetylcholine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acetylcholine binding ISO
    Inferred from Sequence Orthology
    more info
     
    acetylcholine receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    acetylcholine-gated cation-selective channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acetylcholine-gated cation-selective channel activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acetylcholine-gated cation-selective channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acetylcholine-gated cation-selective channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    drug binding ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular ligand-gated ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    B cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acetylcholine receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acetylcholine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    action potential IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    associative learning IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    behavioral response to nicotine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    behavioral response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    central nervous system neuron axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    central nervous system projection neuron axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cognition ISO
    Inferred from Sequence Orthology
    more info
     
    conditioned taste aversion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    lateral geniculate nucleus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    learning ISO
    Inferred from Sequence Orthology
    more info
     
    locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    memory ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nervous system process ISO
    Inferred from Sequence Orthology
    more info
     
    optic nerve morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of B cell proliferation IC
    Inferred by Curator
    more info
    PubMed 
    positive regulation of B cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of dopamine secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of dopamine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synaptic transmission, dopaminergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein heterooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of circadian sleep/wake cycle, REM sleep IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of circadian sleep/wake cycle, non-REM sleep IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of dopamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of dopamine secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of membrane potential IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of synaptic transmission, dopaminergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to acetylcholine ISO
    Inferred from Sequence Orthology
    more info
     
    response to cocaine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    response to nicotine IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to nicotine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    smooth muscle contraction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    social behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synaptic transmission involved in micturition IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    synaptic transmission, cholinergic IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    synaptic transmission, cholinergic ISO
    Inferred from Sequence Orthology
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    vestibulocochlear nerve development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    visual learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    visual learning ISO
    Inferred from Sequence Orthology
    more info
     
    visual perception IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    acetylcholine-gated channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acetylcholine-gated channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    plasma membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    synapse IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    neuronal acetylcholine receptor subunit beta-2
    Names
    acetylcholine receptor beta 2 neural

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009602.4NP_033732.2  neuronal acetylcholine receptor subunit beta-2 precursor

      See identical proteins and their annotated locations for NP_033732.2

      Status: VALIDATED

      Source sequence(s)
      AK051742, BC065103, BY123599
      Consensus CDS
      CCDS17515.1
      UniProtKB/Swiss-Prot
      Q9ERK7
      Related
      ENSMUSP00000029562.3, OTTMUSP00000070560, ENSMUST00000029562.4, OTTMUST00000132332
      Conserved Domains (3) summary
      TIGR00860
      Location:29478
      LIC; Cation transporter family protein
      pfam02931
      Location:29234
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:241477
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      89753448..89764632 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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