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    VSNL1 visinin like 1 [ Homo sapiens (human) ]

    Gene ID: 7447, updated on 22-Apr-2017
    Official Symbol
    VSNL1provided by HGNC
    Official Full Name
    visinin like 1provided by HGNC
    Primary source
    HGNC:HGNC:12722
    See related
    Ensembl:ENSG00000163032 MIM:600817; Vega:OTTHUMG00000090645
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HLP3; VILIP; HPCAL3; HUVISL1; VILIP-1
    Summary
    This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. The encoded protein is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    2p24.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 2 NC_000002.12 (17540540..17656439)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (17721807..17837706)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373448 Neighboring gene nascent polypeptide-associated complex alpha subunit pseudogene Neighboring gene RAD51 associated protein 2 Neighboring gene structural maintenance of chromosomes 6 Neighboring gene uncharacterized LOC105373449 Neighboring gene GEN1, Holliday junction 5' flap endonuclease

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    visinin-like protein 1
    Names
    VLP-1
    hippocalcin-like protein 3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003385.4NP_003376.2  visinin-like protein 1

      See identical proteins and their annotated locations for NP_003376.2

      Status: REVIEWED

      Source sequence(s)
      AI143139, BC022012, BF055598, BI544338
      Consensus CDS
      CCDS1689.1
      UniProtKB/Swiss-Prot
      P62760
      Related
      ENSP00000295156.4, OTTHUMP00000115804, ENST00000295156.8, OTTHUMT00000207305
      Conserved Domains (2) summary
      COG5126
      Location:15181
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:65125
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p7 Primary Assembly

      Range
      17540540..17656439
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      17651208..17767107
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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