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    SULT1E1 sulfotransferase family 1E member 1 [ Homo sapiens (human) ]

    Gene ID: 6783, updated on 7-May-2017
    Official Symbol
    SULT1E1provided by HGNC
    Official Full Name
    sulfotransferase family 1E member 1provided by HGNC
    Primary source
    HGNC:HGNC:11377
    See related
    Ensembl:ENSG00000109193 MIM:600043; Vega:OTTHUMG00000129403
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EST; STE; EST-1; ST1E1
    Summary
    Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    4q13.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 4 NC_000004.12 (69841212..69860152, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (70706930..70725870, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene sulfotransferase family 1B member 1 Neighboring gene sulfotransferase family 1D member 1, pseudogene Neighboring gene casein alpha s1 Neighboring gene casein beta

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Biological oxidations, organism-specific biosystem (from REACTOME)
      Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
    • Cytosolic sulfonation of small molecules, organism-specific biosystem (from REACTOME)
      Cytosolic sulfonation of small molecules, organism-specific biosystemTwo groups of sulfotransferease (SULT) enzymes catalyze the transfer of a sulfate group from 3-phosphoadenosine 5-phosphosulfate (PAPS) to a hydroxyl group on an acceptor molecule, yielding a sulfona...
    • Estrogen metabolism, organism-specific biosystem (from WikiPathways)
      Estrogen metabolism, organism-specific biosystem
      Estrogen metabolism
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metapathway biotransformation, organism-specific biosystem (from WikiPathways)
      Metapathway biotransformation, organism-specific biosystem
      Metapathway biotransformation
    • Phase II conjugation, organism-specific biosystem (from REACTOME)
      Phase II conjugation, organism-specific biosystemPhase II of biotransformation is concerned with conjugation, that is using groups from cofactors to react with functional groups present or introduced from phase I on the compound. The enzymes involv...
    • Photodynamic therapy-induced unfolded protein response, organism-specific biosystem (from WikiPathways)
      Photodynamic therapy-induced unfolded protein response, organism-specific biosystemPhotodynamic therapy may induce a proteotoxic stress response mediated by transcription factors heat shock factor 1 (HSF1), X-box binding protein 1 (XBP1), activating transcription factor (ATF) 6, an...
    • Steroid hormone biosynthesis, organism-specific biosystem (from KEGG)
      Steroid hormone biosynthesis, organism-specific biosystemSteroid hormones derived from cholesterol are a class of biologically active compounds in vertebrates. The cholesterol side-chain cleavage enzyme CYP11A1 catalyzes conversion of cholesterol, a C27 co...
    • Steroid hormone biosynthesis, conserved biosystem (from KEGG)
      Steroid hormone biosynthesis, conserved biosystemSteroid hormones derived from cholesterol are a class of biologically active compounds in vertebrates. The cholesterol side-chain cleavage enzyme CYP11A1 catalyzes conversion of cholesterol, a C27 co...
    • Sulfation Biotransformation Reaction, organism-specific biosystem (from WikiPathways)
      Sulfation Biotransformation Reaction, organism-specific biosystemMetabolism of xenobiotic compounds consists of phase I and a phase II biotransformation reactions, being compound modification and conjugation reactions respectively. In phase I biotransformation, th...
    • Tamoxifen metabolism, organism-specific biosystem (from WikiPathways)
      Tamoxifen metabolism, organism-specific biosystem
      Tamoxifen metabolism
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC34459

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    aryl sulfotransferase activity TAS
    Traceable Author Statement
    more info
     
    estrone sulfotransferase activity TAS
    Traceable Author Statement
    more info
     
    flavonol 3-sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    steroid binding IEA
    Inferred from Electronic Annotation
    more info
     
    steroid sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    steroid sulfotransferase activity TAS
    Traceable Author Statement
    more info
     
    sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    3'-phosphoadenosine 5'-phosphosulfate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    3'-phosphoadenosine 5'-phosphosulfate metabolic process TAS
    Traceable Author Statement
    more info
     
    estrogen catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    estrogen metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ethanol catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    steroid metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    sulfation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    estrogen sulfotransferase
    Names
    estrone sulfotransferase
    sulfotransferase 1E1
    sulfotransferase family 1E, estrogen-preferring, member 1
    sulfotransferase, estrogen-preferring
    NP_005411.1
    XP_011530512.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005420.2NP_005411.1  estrogen sulfotransferase

      See identical proteins and their annotated locations for NP_005411.1

      Status: REVIEWED

      Source sequence(s)
      BC027956
      Consensus CDS
      CCDS3531.1
      UniProtKB/Swiss-Prot
      P49888
      UniProtKB/TrEMBL
      Q53X91
      Related
      ENSP00000226444.3, OTTHUMP00000159769, ENST00000226444.3, OTTHUMT00000251559
      Conserved Domains (1) summary
      pfam00685
      Location:37287
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p7 Primary Assembly

      Range
      69841212..69860152 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011532210.2XP_011530512.1  estrogen sulfotransferase isoform X1

      Conserved Domains (1) summary
      pfam00685
      Location:37165
      Sulfotransfer_1; Sulfotransferase domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018915.2 Alternate CHM1_1.1

      Range
      70743366..70762280 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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