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    PCA3 prostate cancer associated 3 (non-protein coding) [ Homo sapiens (human) ]

    Gene ID: 50652, updated on 1-Oct-2017
    Official Symbol
    PCA3provided by HGNC
    Official Full Name
    prostate cancer associated 3 (non-protein coding)provided by HGNC
    Primary source
    HGNC:HGNC:8637
    See related
    Ensembl:ENSG00000225937 MIM:604845
    Gene type
    ncRNA
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DD3; PCAT3; NCRNA00019
    Summary
    This gene produces a spliced, long non-coding RNA that is highly overexpressed in most types of prostate cancer cells and is used as a specific biomarker for this type of cancer. This gene is embedded in an intronic region of the prune2 gene on the opposite DNA strand. The transcript regulates prune2 levels through formation of a double-stranded RNA that undergoes adenosine deaminase acting on RNA-dependent adenosine-to-inosine RNA editing. In prostate cancer derived cells, overexpression of PCA induced downregulation of prune2, leading to decreased cell proliferation. Conversely, silencing in prostate cancer cells resulted in increased proliferation. Regulation of this gene appears to be sensitive to androgen-receptor activation, a molecular signature of prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]
    Location:
    9q21.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 9 NC_000009.12 (76764436..76787569)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (79379354..79402838)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376093 Neighboring gene peptidylprolyl isomerase A pseudogene 87 Neighboring gene uncharacterized LOC105376095 Neighboring gene prune homolog 2 Neighboring gene lysophospholipase II pseudogene 3 Neighboring gene forkhead box B2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Other Names

    • prostate cancer antigen 3 (non-protein coding)
    • prostate cancer associated transcript 3 (non-protein coding)
    • prostate-specific gene DD3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_015342.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal exon compared to variant 1.
      Source sequence(s)
      AF103907, AY894120
    2. NR_132312.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AF103907, AY894120
      Related
      ENST00000412654.1
    3. NR_132313.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an internal exon and uses an alternate splice site, which results in a shorter transcript compared to variant 1.
      Source sequence(s)
      AF103907, AY894120, DQ374661

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p7 Primary Assembly

      Range
      76764436..76787569
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018920.2 Alternate CHM1_1.1

      Range
      79525809..79548942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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