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    Mecp2 methyl CpG binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 17257, updated on 25-Apr-2017
    Official Symbol
    Mecp2provided by MGI
    Official Full Name
    methyl CpG binding protein 2provided by MGI
    Primary source
    MGI:MGI:99918
    See related
    Ensembl:ENSMUSG00000031393 Vega:OTTMUSG00000017654
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mbd5; WBP10; 1500041B07Rik; D630021H01Rik
    Orthologs
    Location:
    X A7.3; X 37.63 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (74026592..74085690, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (71272160..71330975, complement)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene interleukin-1 receptor-associated kinase 1 Neighboring gene microRNA 5132 Neighboring gene microRNA 718 Neighboring gene opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan) Neighboring gene predicted gene 6758 Neighboring gene testis expressed 28

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Lung fibrosis, organism-specific biosystem (from WikiPathways)
      Lung fibrosis, organism-specific biosystem(Nanoparticle) induced lung fibrosis pathway. Under construction. Note! Mouse homologues for SERPINA1 and SFTPA2 are missing and the pathway currently contains the human equivalents. Other users are ...
    • Mecp2 and Associated Rett Syndrome, organism-specific biosystem (from WikiPathways)
      Mecp2 and Associated Rett Syndrome, organism-specific biosystemMecp2 is in many mammals an important regulator of neuronal function and development. It affects all cell types, especially neurons but also astrocytes, oligodendrocytes, and glial cells. Mecp2 plays...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    core promoter binding ISO
    Inferred from Sequence Orthology
    more info
     
    double-stranded methylated DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    double-stranded methylated DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-stranded methylated DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    double-stranded methylated DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    four-way junction DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    methyl-CpG binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    methyl-CpG binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    siRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    unmethylated CpG binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    behavioral fear response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiolipin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    catecholamine secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular biogenic amine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to isoquinoline alkaloid ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to potassium ion ISO
    Inferred from Sequence Orthology
    more info
     
    cerebellum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chromatin silencing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryo development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucocorticoid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glutamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inositol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrial electron transport, ubiquinol to cytochrome c IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organismal response to stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of astrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of histone acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of histone methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of primary miRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of smooth muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated TAS
    Traceable Author Statement
    more info
    PubMed 
    neurological system process involved in regulation of systemic arterial blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuromuscular process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuromuscular process controlling posture IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pathogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphatidylcholine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of anterograde dense core granule transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of branching morphogenesis of a nerve ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of histone H3-K9 trimethylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of retrograde dense core granule transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proprioception IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of DNA methylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of gene expression by genetic imprinting IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gene expression, epigenetic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of respiratory gaseous exchange by neurological system process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    respiratory gaseous exchange IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to cocaine ISO
    Inferred from Sequence Orthology
    more info
     
    response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    social behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    social behavior ISO
    Inferred from Sequence Orthology
    more info
     
    startle response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    ventricular system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    visual learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with gamma-tubulin complex ISO
    Inferred from Sequence Orthology
    more info
     
    heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    methyl-CpG-binding protein 2
    Names
    meCp-2 protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081979.2NP_001075448.1  methyl-CpG-binding protein 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, also known as alpha) represents the shorter transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK158664, AL672002, BU700810
      Consensus CDS
      CCDS41016.1
      UniProtKB/Swiss-Prot
      Q9Z2D6
      Related
      ENSMUSP00000033770.6, OTTMUSP00000019680, ENSMUST00000033770.12, OTTMUST00000043832
      Conserved Domains (1) summary
      smart00391
      Location:109186
      MBD; Methyl-CpG binding domain
    2. NM_010788.4NP_034918.1  methyl-CpG-binding protein 2 isoform 2

      See identical proteins and their annotated locations for NP_034918.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2, also known as beta) has an additional exon in the 5' region, which results in the use of an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AL672002, BU700810
      Consensus CDS
      CCDS41017.1
      UniProtKB/Swiss-Prot
      Q9Z2D6
      Related
      ENSMUSP00000098314.3, OTTMUSP00000019241, ENSMUST00000100750.9, OTTMUST00000042852
      Conserved Domains (1) summary
      smart00391
      Location:92169
      MBD; Methyl-CpG binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      74026592..74085690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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