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    Fyn Fyn proto-oncogene [ Mus musculus (house mouse) ]

    Gene ID: 14360, updated on 12-Nov-2017
    Official Symbol
    Fynprovided by MGI
    Official Full Name
    Fyn proto-oncogeneprovided by MGI
    Primary source
    MGI:MGI:95602
    See related
    Ensembl:ENSMUSG00000019843 Vega:OTTMUSG00000034130
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI448320; AW552119
    Orthologs
    Location:
    10 B1; 10 20.51 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (39369769..39565381)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (39089605..39285187)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 31562 Neighboring gene predicted gene, 31616 Neighboring gene predicted gene 16364 Neighboring gene predicted gene 16364 Neighboring gene RIKEN cDNA E130307A14 gene Neighboring gene predicted gene, 40627 Neighboring gene TRAF3 interacting protein 2

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC115870

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    CD4 receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    CD8 receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    G-protein coupled receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    T cell receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    disordered domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    ephrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    ion channel binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    peptide hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol 3-kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    signal transducer activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    type 5 metabotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    activated T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to platelet-derived growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to transforming growth factor beta stimulus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    detection of mechanical stimulus involved in sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    forebrain development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    myelination TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of dendritic spine maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-tyrosine autophosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of neuron death IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of neuron projection development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein localization to nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein targeting to membrane IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of tyrosine phosphorylation of STAT protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of calcium ion import across plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of cell shape IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of peptidyl-tyrosine phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to amyloid-beta IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to ethanol IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    actin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    tyrosine-protein kinase Fyn
    Names
    Src Kinase p59
    p59-Fyn
    proto-oncogene c-Fyn
    proto-oncogene tyrosine-protein kinase Fyn
    NP_001116364.1
    NP_001116365.1
    NP_032080.2
    XP_006512602.1
    XP_006512603.1
    XP_011241419.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122892.1NP_001116364.1  tyrosine-protein kinase Fyn isoform b

      See identical proteins and their annotated locations for NP_001116364.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame exon in the coding region and differs in the 5' UTR compared to variant 1. It encodes an isoform (b) with a different and shorter internal segment compared to isoform a. Variants 2 and 3 encode the same isoform (b).
      Source sequence(s)
      BC092217, BE952821, BF662030, BQ714273
      Consensus CDS
      CCDS23788.1
      UniProtKB/Swiss-Prot
      P39688
      Related
      ENSMUSP00000115233.1, OTTMUSP00000046779, ENSMUST00000126486.7, OTTMUST00000086388
      Conserved Domains (3) summary
      cd10368
      Location:145245
      SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn
      cd12006
      Location:85140
      SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
      cd05070
      Location:258531
      PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
    2. NM_001122893.1NP_001116365.1  tyrosine-protein kinase Fyn isoform a

      See identical proteins and their annotated locations for NP_001116365.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      BC092217, BE952821, BF662030, BQ179147, BQ714273, M27266
      Consensus CDS
      CCDS48538.1
      UniProtKB/Swiss-Prot
      P39688
      Related
      ENSMUSP00000097547.3, OTTMUSP00000046778, ENSMUST00000099967.9, OTTMUST00000086387
      Conserved Domains (3) summary
      cd10418
      Location:145245
      SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
      cd12006
      Location:85140
      SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
      cd05070
      Location:261534
      PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
    3. NM_008054.2NP_032080.2  tyrosine-protein kinase Fyn isoform b

      See identical proteins and their annotated locations for NP_032080.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame exon in the coding region compared to variant 1. It encodes an isoform (b) with a different and shorter internal segment compared to isoform a. Variants 2 and 3 encode the same isoform (b).
      Source sequence(s)
      BC092217, BE952821, BF662030, BQ714273, M27266
      Consensus CDS
      CCDS23788.1
      UniProtKB/Swiss-Prot
      P39688
      Related
      ENSMUSP00000057707.6, OTTMUSP00000046777, ENSMUST00000063091.12, OTTMUST00000086386
      Conserved Domains (3) summary
      cd10368
      Location:145245
      SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn
      cd12006
      Location:85140
      SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
      cd05070
      Location:258531
      PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      39369769..39565381
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243117.2XP_011241419.1  tyrosine-protein kinase Fyn isoform X1

      See identical proteins and their annotated locations for XP_011241419.1

      UniProtKB/Swiss-Prot
      P39688
      Conserved Domains (3) summary
      cd10418
      Location:145245
      SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
      cd12006
      Location:85140
      SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
      cd05070
      Location:261534
      PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
    2. XM_006512540.3XP_006512603.1  tyrosine-protein kinase Fyn isoform X1

      See identical proteins and their annotated locations for XP_006512603.1

      UniProtKB/Swiss-Prot
      P39688
      Related
      ENSMUSP00000118131.1, OTTMUSP00000046784, ENSMUST00000136659.1, OTTMUST00000086393
      Conserved Domains (3) summary
      cd10418
      Location:145245
      SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
      cd12006
      Location:85140
      SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
      cd05070
      Location:261534
      PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
    3. XM_006512539.3XP_006512602.1  tyrosine-protein kinase Fyn isoform X1

      See identical proteins and their annotated locations for XP_006512602.1

      UniProtKB/Swiss-Prot
      P39688
      Conserved Domains (3) summary
      cd10418
      Location:145245
      SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
      cd12006
      Location:85140
      SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
      cd05070
      Location:261534
      PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
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