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    JUND JunD proto-oncogene, AP-1 transcription factor subunit [ Homo sapiens (human) ]

    Gene ID: 3727, updated on 5-Nov-2017
    Official Symbol
    JUNDprovided by HGNC
    Official Full Name
    JunD proto-oncogene, AP-1 transcription factor subunitprovided by HGNC
    Primary source
    HGNC:HGNC:6206
    See related
    Ensembl:ENSG00000130522 MIM:165162; Vega:OTTHUMG00000183355
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AP-1
    Summary
    The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013]
    Orthologs
    Location:
    19p13.11
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (18279694..18281656, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (18390563..18392432, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC729966 Neighboring gene IQ motif containing N Neighboring gene microRNA 3188 Neighboring gene ribosomal protein L39 pseudogene 38

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Vpu vpu HIV-1 Vpu-expressing U937 monocytes coculture with LX2 stellate cells to activate release of transforming growth factor beta to culture supernatant, which correlates with increased activity of the AP-1 transcription factor PubMed

    Go to the HIV-1, Human Interaction Database

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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA polymerase II proximal promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ligand-dependent nuclear receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    aging IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    circadian rhythm IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    osteoblast development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of cell death IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    PubMed 
    response to cAMP IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to cytokine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to drug IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to light stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to mechanical stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to peptide hormone IEA
    Inferred from Electronic Annotation
    more info
     
    response to radiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    chromatin TAS
    Traceable Author Statement
    more info
    PubMed 
    nuclear chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    protein-DNA complex IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor AP-1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    transcription factor jun-D
    Names
    JunD-FL isoform
    activator protein 1
    jun D proto-oncogene

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286968.1NP_001273897.1  transcription factor jun-D isoform deltaJunD

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes two isoforms resulting from the use of alternative in-frame translation initiation codons. The longer isoform (JunD-FL) is derived from an upstream AUG (S1 ORF, PMID:12105216), while the shorter isoform (deltaJunD) is derived from a downstream AUG (S3 ORF, PMID:12105216). This RefSeq represents the shorter isoform (deltaJunD).
      Source sequence(s)
      AK223630, AW027337, BQ130444, CB050506, HY026893
      UniProtKB/Swiss-Prot
      P17535
      Conserved Domains (2) summary
      cd14696
      Location:227286
      bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain
      pfam03957
      Location:1214
      Jun; Jun-like transcription factor
    2. NM_005354.5NP_005345.3  transcription factor jun-D isoform JunD-FL

      See identical proteins and their annotated locations for NP_005345.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes two isoforms resulting from the use of alternative in-frame translation initiation codons. The longer isoform (JunD-FL) is derived from an upstream AUG (S1 ORF, PMID:12105216), while the shorter isoform (deltaJunD) is derived from a downstream AUG (S3 ORF, PMID:12105216). This RefSeq represents the longer isoform (JunD-FL).
      Source sequence(s)
      AK223630, AW027337, BQ130444, CB050506, HY026893
      Consensus CDS
      CCDS32959.1
      UniProtKB/Swiss-Prot
      P17535
      Related
      ENSP00000252818.3, OTTHUMP00000271527, ENST00000252818.4, OTTHUMT00000466318
      Conserved Domains (2) summary
      cd14696
      Location:270329
      bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain
      pfam03957
      Location:1257
      Jun; Jun-like transcription factor

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

      Range
      18279694..18281656 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      18390750..18392712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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