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    Sparc secreted acidic cysteine rich glycoprotein [ Mus musculus (house mouse) ]

    Gene ID: 20692, updated on 24-Mar-2017
    Official Symbol
    Sparcprovided by MGI
    Official Full Name
    secreted acidic cysteine rich glycoproteinprovided by MGI
    Primary source
    MGI:MGI:98373
    See related
    Ensembl:ENSMUSG00000018593 Vega:OTTMUSG00000005692
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ON; BM-40
    Orthologs
    Location:
    11 B1.3; 11 33.04 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (55394159..55420080, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (55208003..55233582, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene FAT atypical cadherin 2 Neighboring gene predicted gene, 31842 Neighboring gene antioxidant 1 copper chaperone Neighboring gene predicted gene 12235

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    collagen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    collagen binding ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    bone development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lung development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    basement membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    platelet alpha granule ISO
    Inferred from Sequence Orthology
    more info
     
    platelet alpha granule membrane ISO
    Inferred from Sequence Orthology
    more info
     
    proteinaceous extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    SPARC
    Names
    basement-membrane protein 40
    osteonectin
    secreted protein acidic and rich in cysteine

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290817.1NP_001277746.1  SPARC isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AA798908, AK148670, AK161229, BB857564, BE655213, BY781653, CJ132527
      Consensus CDS
      CCDS70189.1
      UniProtKB/TrEMBL
      Q5NCU4, Q5NCU5
      Related
      ENSMUSP00000104486, OTTMUSP00000005869, ENSMUST00000108858, OTTMUST00000012667
      Conserved Domains (3) summary
      cd00252
      Location:152299
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      cd01328
      Location:69150
      FSL_SPARC; Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain; SPARC/BM-40/osteonectin is a multifunctional glycoprotein which modulates cellular interaction with the extracellular matrix by its binding to structural matrix proteins ...
      pfam10591
      Location:152285
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region
    2. NM_009242.5NP_033268.1  SPARC precursor

      See identical proteins and their annotated locations for NP_033268.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA798908, AK161229, BB857564, BE655213, BY781653, CJ132527
      Consensus CDS
      CCDS24712.1
      UniProtKB/Swiss-Prot
      P07214
      UniProtKB/TrEMBL
      Q5NCU5
      Related
      ENSMUSP00000018737, OTTMUSP00000005868, ENSMUST00000018737, OTTMUST00000012666
      Conserved Domains (3) summary
      cd00252
      Location:153300
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      cd01328
      Location:70151
      FSL_SPARC; Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain; SPARC/BM-40/osteonectin is a multifunctional glycoprotein which modulates cellular interaction with the extracellular matrix by its binding to structural matrix proteins ...
      pfam10591
      Location:153286
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      55394159..55420080 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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