Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Nlrx1 NLR family member X1 [ Mus musculus (house mouse) ]

    Gene ID: 270151, updated on 5-Nov-2017
    Official Symbol
    Nlrx1provided by MGI
    Official Full Name
    NLR family member X1provided by MGI
    Primary source
    MGI:MGI:2429611
    See related
    Ensembl:ENSMUSG00000032109 Vega:OTTMUSG00000063221
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NOD9; BC034204
    Orthologs
    Location:
    9; 9 A5.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (44252713..44268599, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (44060796..44076682, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 153 Neighboring gene PDZ domain containing 3 Neighboring gene ATP binding cassette subfamily G member 4 Neighboring gene histone H4 transcription factor

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Potential readthrough

    Included gene: Pdzd3

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of RIG-I signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interferon-beta production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    NLR family member X1
    Names
    nucleotide-binding domain and leucine-rich repeat containing

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163742.1NP_001157214.1  NLR family member X1

      See identical proteins and their annotated locations for NP_001157214.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK166689, BC035045, BY196718
      Consensus CDS
      CCDS23100.1
      UniProtKB/Swiss-Prot
      Q3TL44
      Related
      ENSMUSP00000127531.1, OTTMUSP00000079634, ENSMUST00000168499.8, OTTMUST00000153958
      Conserved Domains (3) summary
      cd00116
      Location:698903
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:698726
      LRR_RI; leucine-rich repeat [structural motif]
      cl21455
      Location:161320
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. NM_001163743.1NP_001157215.1  NLR family member X1

      See identical proteins and their annotated locations for NP_001157215.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC124577, BC035045
      Consensus CDS
      CCDS23100.1
      UniProtKB/Swiss-Prot
      Q3TL44
      Related
      ENSMUSP00000126555.1, OTTMUSP00000079633, ENSMUST00000169651.2, OTTMUST00000153957
      Conserved Domains (3) summary
      cd00116
      Location:698903
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:698726
      LRR_RI; leucine-rich repeat [structural motif]
      cl21455
      Location:161320
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    3. NM_178420.3NP_848507.2  NLR family member X1

      See identical proteins and their annotated locations for NP_848507.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC124577, AK145988, BC035045
      Consensus CDS
      CCDS23100.1
      UniProtKB/Swiss-Prot
      Q3TL44
      Related
      ENSMUSP00000034621.8, OTTMUSP00000079632, ENSMUST00000034621.15, OTTMUST00000153956
      Conserved Domains (3) summary
      cd00116
      Location:698903
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:698726
      LRR_RI; leucine-rich repeat [structural motif]
      cl21455
      Location:161320
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      44252713..44268599 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center