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    CRY2 cryptochrome circadian clock 2 [ Homo sapiens (human) ]

    Gene ID: 1408, updated on 22-Sep-2016
    Official Symbol
    CRY2provided by HGNC
    Official Full Name
    cryptochrome circadian clock 2provided by HGNC
    Primary source
    HGNC:HGNC:2385
    See related
    Ensembl:ENSG00000121671 HPRD:07226; MIM:603732; Vega:OTTHUMG00000153225
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HCRY2; PHLL2
    Summary
    This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
    Orthologs
    Location:
    11p11.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (45847118..45883248)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (45868669..45904799)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized DKFZp779M0652 Neighboring gene solute carrier family 35 member C1 Neighboring gene mitogen-activated protein kinase 8 interacting protein 1 Neighboring gene chromosome 11 open reading frame 94

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
    NHGRI GWA Catalog
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    NHGRI GWA Catalog
    New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
    NHGRI GWA Catalog
    Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
    NHGRI GWA Catalog
    • BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystem (from REACTOME)
      BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystemAs inferred from mouse, BMAL1:CLOCK (ARNTL:CLOCK) and BMAL1:NPAS2 (ARNTL:NPAS2) heterodimers bind to sequence elements (E boxes) in the promoters of target genes and enhance transcription (Gekakis et...
    • Circadian Clock, organism-specific biosystem (from REACTOME)
      Circadian Clock, organism-specific biosystemAt the center of the mammalian circadian clock is a negative transcription/translation-based feedback loop: The BMAL1:CLOCK/NPAS2 (ARNTL:CLOCK/NPAS2) heterodimer transactivates CRY and PER genes by b...
    • Circadian rhythm, organism-specific biosystem (from KEGG)
      Circadian rhythm, organism-specific biosystemCircadian rhythm is an internal biological clock, which enables to sustain an approximately 24-hour rhythm in the absence of environmental cues. In mammals, the circadian clock mechanism consists of ...
    • Circadian rhythm, conserved biosystem (from KEGG)
      Circadian rhythm, conserved biosystemCircadian rhythm is an internal biological clock, which enables to sustain an approximately 24-hour rhythm in the absence of environmental cues. In mammals, the circadian clock mechanism consists of ...
    • Diurnally regulated genes with circadian orthologs, organism-specific biosystem (from WikiPathways)
      Diurnally regulated genes with circadian orthologs, organism-specific biosystemHuman genes regulated in the diurnal comparison with orthologues that display circadian regulation in mouse heart and liver (Panda 2002, Storch 2002), and SCN (Panda 2002). The 608 significantly regu...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ10332, KIAA0658

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT DNA (6-4) photolyase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    FAD binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    blue light photoreceptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    damaged DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT deoxyribodipyrimidine photo-lyase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, transcription factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription regulatory region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    blue light signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    circadian regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    circadian rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    entrainment of circadian clock by photoperiod ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of circadian rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of glucocorticoid receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT photoreactive repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-chromophore linkage IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of circadian rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of sodium-dependent phosphate transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    cryptochrome-2
    Names
    cryptochrome 2 (photolyase-like)
    growth-inhibiting protein 37

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127457.2NP_001120929.1  cryptochrome-2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate first exon which contains the predicted translation start site; the resulting protein has a distinct N-terminus.
      Source sequence(s)
      AC068385, AI375851, BC041814, DC330290
      Consensus CDS
      CCDS44576.1
      UniProtKB/Swiss-Prot
      Q49AN0
      Related
      ENSP00000397419, OTTHUMP00000203440, ENST00000417225, OTTHUMT00000330236
      Conserved Domains (3) summary
      COG0415
      Location:2449
      PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]
      pfam00875
      Location:11111
      DNA_photolyase; DNA photolyase
      pfam03441
      Location:171444
      FAD_binding_7; FAD binding domain of DNA photolyase
    2. NM_021117.3NP_066940.2  cryptochrome-2 isoform 1

      See identical proteins and their annotated locations for NP_066940.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses an alternate first exon which contains the predicted translation start site; the resulting protein has a distinct N-terminus.
      Source sequence(s)
      AC068385, AI375851, AK302865, BC041814
      Consensus CDS
      CCDS7915.2
      UniProtKB/Swiss-Prot
      Q49AN0
      UniProtKB/TrEMBL
      A0A0D2X7Z3
      Related
      ENSP00000478187, ENST00000616623
      Conserved Domains (3) summary
      COG0415
      Location:43531
      PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]
      pfam00875
      Location:45193
      DNA_photolyase; DNA photolyase
      pfam03441
      Location:253526
      FAD_binding_7; FAD binding domain of DNA photolyase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      45847118..45883248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      45866091..45902224
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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