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    Lox lysyl oxidase [ Mus musculus (house mouse) ]

    Gene ID: 16948, updated on 4-Jun-2017
    Official Symbol
    Loxprovided by MGI
    Official Full Name
    lysyl oxidaseprovided by MGI
    Primary source
    MGI:MGI:96817
    See related
    Ensembl:ENSMUSG00000024529
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    rrg; TSC-160; AI893619
    Summary
    This gene encodes a precursor protein that belongs to the lysyl oxidase family of proteins. The secreted proprotein is proteolytically processed to an active mature peptide and a propeptide. This propeptide is thought to function in tumor suppression by inhibiting the Ras signaling pathway. The active enzyme plays a role in cross-linking of collagen and elastin and is essential for development of cardiovascular and respiratory systems, and development of skin and connective tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
    Orthologs
    Location:
    18 D1; 18 28.22 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (52516060..52529867, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (52676892..52689362, complement)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene ferritin mitochondrial Neighboring gene serum response factor binding protein 1 Neighboring gene ribosomal protein S3A pseudogene Neighboring gene predicted gene, 41724

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Chemically induced (ENU) (1) 
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    copper ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-lysine 6-oxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-lysine 6-oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    aorta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    collagen fibril organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    collagen fibril organization ISO
    Inferred from Sequence Orthology
    more info
     
    elastic fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    elastic fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    response to hormone ISO
    Inferred from Sequence Orthology
    more info
     
    response to steroid hormone ISO
    Inferred from Sequence Orthology
    more info
     
    wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    collagen trimer IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    proteinaceous extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteinaceous extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    protein-lysine 6-oxidase
    Names
    ras excision protein
    ras recision
    NP_001273110.1
    NP_001273111.1
    NP_034858.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286181.1NP_001273110.1  protein-lysine 6-oxidase preproprotein

      See identical proteins and their annotated locations for NP_001273110.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC161119, AK141995, AK164634, BB840428, BQ033730
      Consensus CDS
      CCDS50289.1
      UniProtKB/Swiss-Prot
      P28301
      UniProtKB/TrEMBL
      Q3TP83, Q3TXH3
      Conserved Domains (1) summary
      pfam01186
      Location:207403
      Lysyl_oxidase; Lysyl oxidase
    2. NM_001286182.1NP_001273111.1  protein-lysine 6-oxidase preproprotein

      See identical proteins and their annotated locations for NP_001273111.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC109203, AK164634, BQ033730
      Consensus CDS
      CCDS50289.1
      UniProtKB/Swiss-Prot
      P28301
      UniProtKB/TrEMBL
      Q3TP83, Q3TXH3
      Related
      ENSMUSP00000129247.1, ENSMUST00000171470.7
      Conserved Domains (1) summary
      pfam01186
      Location:207403
      Lysyl_oxidase; Lysyl oxidase
    3. NM_010728.3NP_034858.2  protein-lysine 6-oxidase preproprotein

      See identical proteins and their annotated locations for NP_034858.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC161119, AK141995, AK164634, BQ033730
      Consensus CDS
      CCDS50289.1
      UniProtKB/Swiss-Prot
      P28301
      UniProtKB/TrEMBL
      Q3TP83, Q3TXH3
      Related
      ENSMUSP00000025409.7, ENSMUST00000025409.7
      Conserved Domains (1) summary
      pfam01186
      Location:207403
      Lysyl_oxidase; Lysyl oxidase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

      Range
      52516060..52529867 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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