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    Adam17 a disintegrin and metallopeptidase domain 17 [ Mus musculus (house mouse) ]

    Gene ID: 11491, updated on 13-Aug-2017
    Official Symbol
    Adam17provided by MGI
    Official Full Name
    a disintegrin and metallopeptidase domain 17provided by MGI
    Primary source
    MGI:MGI:1096335
    See related
    Ensembl:ENSMUSG00000052593 Vega:OTTMUSG00000021042
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tace; CD156b
    Summary
    This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature enzyme that is involved in the proteolytic release of membrane-bound proteins in a process called ectodomain shedding. Mice lacking the encoded protein die in utero or fail to survive beyond one week of age. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]
    Orthologs
    Location:
    12 A1.3; 12 8.3 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (21323509..21373632, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (21329370..21379452, complement)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 Neighboring gene integrin beta 1 binding protein 1 Neighboring gene cleavage and polyadenylation specificity factor 3 Neighboring gene isoamyl acetate-hydrolyzing esterase 1 homolog Neighboring gene RIKEN cDNA F630048H11 gene Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta Neighboring gene predicted gene 4419

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Notch binding ISO
    Inferred from Sequence Orthology
    more info
     
    PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-6 receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    metallopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metallopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Notch receptor processing ISO
    Inferred from Sequence Orthology
    more info
     
    Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    PMA-inducible membrane protein ectodomain proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    PMA-inducible membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    T cell differentiation in thymus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
     
    cell motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    germinal center formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane protein ectodomain proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane protein ectodomain proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron projection development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of T cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cellular component movement IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epidermal growth factor-activated receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    production of molecular mediator involved in inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of axon regeneration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of mast cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neuron migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to drug IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to high density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     
    response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    spleen development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 17
    Names
    TNF-alpha convertase
    TNF-alpha converting enzyme
    NP_001264195.1
    NP_001278800.1
    NP_033745.4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277266.1NP_001264195.1  disintegrin and metalloproteinase domain-containing protein 17 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate in-frame exon compared to variant 1. The resulting isoform (2) contains an alternate internal 19 aa segment compared to isoform 1. This isoform (2) may undergo processing similar to isoform 1.
      Source sequence(s)
      AC140457, AC156032, BC094655
      Consensus CDS
      CCDS70376.1
      UniProtKB/Swiss-Prot
      Q9Z0F8
      UniProtKB/TrEMBL
      E9PXU2
      Related
      ENSMUSP00000099087.3, OTTMUSP00000023112, ENSMUST00000101551.9, OTTMUST00000049767
      Conserved Domains (5) summary
      smart00050
      Location:503578
      DISIN; Homologues of snake disintegrins
      cd04270
      Location:223496
      ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
      pfam01562
      Location:56166
      Pep_M12B_propep; Reprolysin family propeptide
      pfam13574
      Location:267479
      Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like
      pfam16698
      Location:600660
      ADAM17_MPD; Membrane-proximal domain, switch, for ADAM17
    2. NM_001291871.1NP_001278800.1  disintegrin and metalloproteinase domain-containing protein 17 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate 5' splice site, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 4) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC140457, AC156032, AK142441, BC094655, BM248808
      UniProtKB/Swiss-Prot
      Q9Z0F8
      Conserved Domains (4) summary
      smart00050
      Location:246321
      DISIN; Homologues of snake disintegrins
      cd04270
      Location:1239
      ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
      pfam13574
      Location:9222
      Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like
      pfam16698
      Location:343403
      ADAM17_MPD; Membrane-proximal domain, switch, for ADAM17
    3. NM_009615.6NP_033745.4  disintegrin and metalloproteinase domain-containing protein 17 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_033745.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the predominant isoform (1).
      Source sequence(s)
      AC140457, AC156032, BC094655
      Consensus CDS
      CCDS25836.1
      UniProtKB/Swiss-Prot
      Q9Z0F8
      Related
      ENSMUSP00000067953.6, OTTMUSP00000023111, ENSMUST00000064536.12, OTTMUST00000049766
      Conserved Domains (5) summary
      smart00050
      Location:484559
      DISIN; Homologues of snake disintegrins
      cd04270
      Location:223477
      ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
      pfam01562
      Location:56166
      Pep_M12B_propep; Reprolysin family propeptide
      pfam13574
      Location:247460
      Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like
      pfam16698
      Location:581641
      ADAM17_MPD; Membrane-proximal domain, switch, for ADAM17

    RNA

    1. NR_102380.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks three alternate exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC140457, AC156032, BC094655
    2. NR_120376.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate 3' splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC140457, AC156032, AK137693, AK142441, AK149614, BC094655, BM248808
      Related
      ENSMUST00000145118.7, OTTMUST00000049772

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      21323509..21373632 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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