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    egl-4 Uncharacterized protein [ Caenorhabditis elegans ]

    Gene ID: 176991, updated on 12-Oct-2017
    Gene symbol
    egl-4
    Gene description
    Uncharacterized protein
    Primary source
    WormBase:WBGene00001173
    Locus tag
    CELE_F55A8.2
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Location:
    chromosome: IV
    Exon count:
    15
    Sequence:
    Chromosome: IV; NC_003282.8 (1848071..1879939)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Calcium/calmodulin-dependent protein kinase type 1 Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    cGMP binding IEA
    Inferred from Electronic Annotation
    more info
     
    cGMP-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cGMP-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    chemoattractant activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    chemoattractant activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    chemosensory behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    chemosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    insulin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    larval feeding behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cGMP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cyclic nucleotide-gated ion channel activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transforming growth factor beta receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    oviposition IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cGMP-mediated signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cGMP-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cyclic-nucleotide phosphodiesterase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of eating behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of multicellular organism growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of oogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of oviposition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to odorant IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to odorant IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to oxygen levels IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sensory perception of bitter taste IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    sensory perception of bitter taste IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sleep IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Names
    Uncharacterized protein
    cGMP-dependent protein kinase
    cGMP-dependent protein kinase egl-4
    NP_001023223.1
    • Confirmed by transcript evidence
    NP_001023224.1
    • Confirmed by transcript evidence
    NP_001294449.1
    • Confirmed by transcript evidence
    NP_001294450.1
    • Partially confirmed by transcript evidence
    NP_500141.1
    • Confirmed by transcript evidence
    NP_500142.1
    • Confirmed by transcript evidence
    NP_741329.1
    • Confirmed by transcript evidence
    NP_741330.2
    • Confirmed by transcript evidence

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      1848071..1879939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001307521.1NP_001294450.1  cGMP-dependent protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294450.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PEQ9
      Conserved Domains (5) summary
      PTZ00263
      Location:461779
      PTZ00263; protein kinase A catalytic subunit; Provisional
      smart00133
      Location:734783
      S_TK_X; Extension to Ser/Thr-type protein kinases
      COG0664
      Location:195316
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:201314
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd05572
      Location:478739
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
    2. NM_067740.4NP_500141.1  cGMP-dependent protein kinase egl-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500141.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76360
      Conserved Domains (5) summary
      PTZ00263
      Location:458776
      PTZ00263; protein kinase A catalytic subunit; Provisional
      smart00133
      Location:731780
      S_TK_X; Extension to Ser/Thr-type protein kinases
      COG0664
      Location:195316
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:319434
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd05572
      Location:475736
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
    3. NM_067741.3NP_500142.1  cGMP-dependent protein kinase egl-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500142.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76360
      Conserved Domains (5) summary
      PTZ00263
      Location:415733
      PTZ00263; protein kinase A catalytic subunit; Provisional
      smart00133
      Location:688737
      S_TK_X; Extension to Ser/Thr-type protein kinases
      COG0664
      Location:152273
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:276391
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd05572
      Location:432693
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
    4. NM_001028052.2NP_001023223.1  cGMP-dependent protein kinase egl-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023223.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76360
      Conserved Domains (5) summary
      PTZ00263
      Location:421739
      PTZ00263; protein kinase A catalytic subunit; Provisional
      smart00133
      Location:694743
      S_TK_X; Extension to Ser/Thr-type protein kinases
      COG0664
      Location:158279
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:282397
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd05572
      Location:438699
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
    5. NM_171279.3NP_741329.1  cGMP-dependent protein kinase egl-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741329.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76360
      Conserved Domains (5) summary
      PTZ00263
      Location:427745
      PTZ00263; protein kinase A catalytic subunit; Provisional
      smart00133
      Location:700749
      S_TK_X; Extension to Ser/Thr-type protein kinases
      COG0664
      Location:164285
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:288403
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd05572
      Location:444705
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
    6. NM_171280.2NP_741330.2  cGMP-dependent protein kinase egl-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741330.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76360
      Conserved Domains (1) summary
      cl00047
      Location:79126
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    7. NM_001307520.1NP_001294449.1  Uncharacterized protein CELE_F55A8.2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294449.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PRL6
      Conserved Domains (5) summary
      PTZ00263
      Location:162480
      PTZ00263; protein kinase A catalytic subunit; Provisional
      smart00133
      Location:435484
      S_TK_X; Extension to Ser/Thr-type protein kinases
      COG0664
      Location:17128
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:23138
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd05572
      Location:179440
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
    8. NM_001028053.2NP_001023224.1  cGMP-dependent protein kinase egl-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023224.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76360
      Conserved Domains (5) summary
      PTZ00263
      Location:148466
      PTZ00263; protein kinase A catalytic subunit; Provisional
      smart00133
      Location:421470
      S_TK_X; Extension to Ser/Thr-type protein kinases
      COG0664
      Location:7114
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:9124
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd05572
      Location:165426
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
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